BRPI0909519A2 - fomação de imagem ocular - Google Patents

fomação de imagem ocular

Info

Publication number
BRPI0909519A2
BRPI0909519A2 BRPI0909519A BRPI0909519A BRPI0909519A2 BR PI0909519 A2 BRPI0909519 A2 BR PI0909519A2 BR PI0909519 A BRPI0909519 A BR PI0909519A BR PI0909519 A BRPI0909519 A BR PI0909519A BR PI0909519 A2 BRPI0909519 A2 BR PI0909519A2
Authority
BR
Brazil
Prior art keywords
image formation
eye image
eye
formation
image
Prior art date
Application number
BRPI0909519A
Other languages
English (en)
Inventor
Dennis J Nillan
Paul Hartung
Vincent Valvo
Original Assignee
Neuroptix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40718786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0909519(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neuroptix Corp filed Critical Neuroptix Corp
Publication of BRPI0909519A2 publication Critical patent/BRPI0909519A2/pt
Publication of BRPI0909519B1 publication Critical patent/BRPI0909519B1/pt
Publication of BRPI0909519B8 publication Critical patent/BRPI0909519B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Human Computer Interaction (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Eye Examination Apparatus (AREA)
BRPI0909519A 2008-03-27 2009-03-27 sistema para realizar a difusão de luz quase-elástica e a varredura de ligante fluorescente em um olho do indivíduo BRPI0909519B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7219908P 2008-03-27 2008-03-27
US61/072,199 2008-03-27
PCT/US2009/001885 WO2009120349A1 (en) 2008-03-27 2009-03-27 Ocular imaging

Publications (3)

Publication Number Publication Date
BRPI0909519A2 true BRPI0909519A2 (pt) 2016-10-11
BRPI0909519B1 BRPI0909519B1 (pt) 2020-03-10
BRPI0909519B8 BRPI0909519B8 (pt) 2021-06-22

Family

ID=40718786

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909519A BRPI0909519B8 (pt) 2008-03-27 2009-03-27 sistema para realizar a difusão de luz quase-elástica e a varredura de ligante fluorescente em um olho do indivíduo

Country Status (19)

Country Link
US (1) US8955969B2 (pt)
EP (1) EP2268193B1 (pt)
JP (1) JP2011515189A (pt)
KR (1) KR101603184B1 (pt)
CN (1) CN102006819B (pt)
AU (1) AU2009229348B2 (pt)
BR (1) BRPI0909519B8 (pt)
CA (1) CA2718938C (pt)
DK (1) DK2268193T3 (pt)
ES (1) ES2584512T3 (pt)
HK (1) HK1145958A1 (pt)
HU (1) HUE028034T2 (pt)
MX (1) MX2010010402A (pt)
NZ (1) NZ588811A (pt)
PL (1) PL2268193T3 (pt)
PT (1) PT2268193T (pt)
RU (1) RU2503399C2 (pt)
SG (1) SG188900A1 (pt)
WO (1) WO2009120349A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE031948T2 (en) 2006-04-11 2017-08-28 Cognoptix Inc Eye image analysis
CA2718938C (en) 2008-03-27 2016-11-29 Neuroptix Corporation Ocular imaging
JP5626760B2 (ja) * 2010-03-31 2014-11-19 ソニー株式会社 蛍光像取得方法、蛍光像取得プログラム及び蛍光像取得装置
EP2420179B1 (en) * 2010-08-16 2020-10-07 Cognoptix, Inc. System and method for detecting amyloid proteins
WO2012061078A2 (en) * 2010-10-25 2012-05-10 Steven Verdooner Apparatus and method for detecting amyloid in a retina in a diagnosis, advancement, and prognosing of alzheimer's disease, traumatic brain injury, macular degeneration and a plurality of neurodegenerative dissorders, and ocular diseases
JP6012614B2 (ja) * 2010-11-05 2016-10-25 フリーダム メディテック インコーポレイテッド 生体組織の構造的性質に影響する疾患を非侵襲的に検出するための装置および方法
US9010935B2 (en) 2011-11-22 2015-04-21 California Institute Of Technology Systems and methods for noninvasive analysis of retinal health and function
EP3922270A1 (en) 2011-12-09 2021-12-15 Regents of the University of Minnesota Hyperspectral imaging for early detection of alzheimer's disease
FR2984565A1 (fr) * 2011-12-19 2013-06-21 Thomson Licensing Procede et dispositif d'estimation de la puissance optique des lentilles de verres correcteurs d'une paire de lunettes portee par un spectateur.
WO2013116812A1 (en) 2012-02-03 2013-08-08 Orthohub, Inc. External fixator deformity correction systems and methods
US9204937B2 (en) 2013-02-19 2015-12-08 Stryker Trauma Gmbh Software for use with deformity correction
CN103605955A (zh) * 2013-11-01 2014-02-26 武汉虹识技术有限公司 一种基于单传感器及光学滤波的图像捕捉装置
NZ719998A (en) * 2013-11-12 2017-08-25 Cognoptix Inc Method for measuring fluorescence in ocular tissue
CN104092935B (zh) 2014-06-05 2018-06-26 西安中兴新软件有限责任公司 一种图像拍摄的处理方法和装置
JP6962968B2 (ja) * 2015-02-02 2021-11-05 アルコン インコーポレイティド 眼疾患の生体力学的診断用の光学機器
KR102017316B1 (ko) * 2015-02-02 2019-09-02 노바르티스 아게 안질환의 신체역학적 진단용 광학 기구
AU2017229876A1 (en) 2016-03-10 2018-11-01 Regents Of The University Of Minnesota Spectral-spatial imaging device
US10010346B2 (en) 2016-04-20 2018-07-03 Stryker European Holdings I, Llc Ring hole planning for external fixation frames
US10251705B2 (en) 2016-06-02 2019-04-09 Stryker European Holdings I, Llc Software for use with deformity correction
US20180085256A1 (en) * 2016-09-12 2018-03-29 Lensar, Inc. Laser methods and systems for the aligned insertion of devices into a structure of the eye
WO2018066062A1 (ja) * 2016-10-04 2018-04-12 マクセル株式会社 投影光学系、及びヘッドアップディスプレイ装置
CN110430799B (zh) * 2017-02-23 2022-03-29 艾维斯技术有限责任公司 用于光学角膜地形图和断层扫描的相干激光
EP3711680A4 (en) 2017-11-14 2021-08-18 Osaka University COGNITIVE MALFUNCTION DIAGNOSIS AND COGNITIVE MALFUNCTION DIAGNOSIS PROGRAM
CN111565624A (zh) 2017-11-27 2020-08-21 雷蒂斯派克股份有限公司 用于阿尔茨海默氏病病理的高光谱图像指导的raman眼科成像仪
US11651488B2 (en) * 2019-10-01 2023-05-16 Yuscan Usa, Llc Devices and methods for determining a disease state based total lens fluorescence
JP2023504709A (ja) * 2019-12-06 2023-02-06 ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド スペクトル調整可能な光学的光感度分析器及びその使用
CN111227785A (zh) * 2020-02-24 2020-06-05 耀视(苏州)医疗科技有限公司 眼球激光扫描成像方法
CN112190227B (zh) * 2020-10-14 2022-01-11 北京鹰瞳科技发展股份有限公司 眼底相机及其使用状态检测方法
JP7189404B1 (ja) 2021-07-26 2022-12-14 防衛装備庁長官 視覚異常検出方法、視覚異常検出装置及び操縦支援システム
US20230190160A1 (en) * 2021-11-24 2023-06-22 Bloonics Holding B.V. System and method for determining intoxicant impairment
WO2023229690A1 (en) * 2022-05-24 2023-11-30 Verily Life Sciences Llc Pathology and/or eye-sided dependent illumination for retinal imaging

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US838134A (en) * 1904-12-20 1906-12-11 John F Nissly Bottle or jar capping machine.
JPS5836969B2 (ja) 1978-01-23 1983-08-12 株式会社甲南カメラ研究所 眼球顕微鏡
US4529556A (en) 1983-08-19 1985-07-16 The Dow Chemical Company Bis((aryl)vinyl)benzenes
US4761071A (en) 1984-11-06 1988-08-02 Baron William S Apparatus and method for determining corneal and scleral topography
US4702576A (en) 1985-09-27 1987-10-27 Cambridge Instruments Inc. Ocular scattering analyzer
US5183044A (en) 1987-06-30 1993-02-02 Kabushiki Kaisha Topcon Noncontact type tonometer
US4806004A (en) 1987-07-10 1989-02-21 California Institute Of Technology Scanning microscopy
US4957113A (en) 1987-09-01 1990-09-18 Massachusetts Institute Of Technology Method for detecting cataractogenesis using quasi-elastic light scattering
US4993827A (en) 1987-09-01 1991-02-19 Massachusetts Institute Of Technology Method for detecting cataractogenesis
JPH0277228A (ja) 1988-09-14 1990-03-16 Kowa Co 眼科測定装置
JPH0282938A (ja) * 1988-09-19 1990-03-23 Topcon Corp 眼科用測定装置
JP2931325B2 (ja) 1989-06-29 1999-08-09 興和株式会社 眼科測定装置
US5048946A (en) 1990-05-15 1991-09-17 Phoenix Laser Systems, Inc. Spectral division of reflected light in complex optical diagnostic and therapeutic systems
US5279296A (en) 1991-01-04 1994-01-18 Oculon Corporation Method and apparatus for detecting cataractogenesis
US6198532B1 (en) * 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
US5303709A (en) 1991-12-16 1994-04-19 Dreher Andreas W Retinal eye disease diagnostic system
JPH05261068A (ja) 1992-03-19 1993-10-12 Topcon Corp 眼科装置
US5392776A (en) 1992-09-21 1995-02-28 Oculon Corporation Method and apparatus for detecting cataractogenesis
US5548354A (en) 1993-06-10 1996-08-20 Konan Common Co., Ltd. Method for observing and photographing a cornea and apparatus for the same
PT101290B (pt) 1993-06-18 2000-10-31 Fernandes Jose Guilherme Da Cu Fluorometro para medicao da concentracao de fluoroforos de localizacao ocular
US5427094A (en) * 1993-11-08 1995-06-27 Oculon Corporation Method and apparatus for detecting cataractogenesis
US5427095A (en) 1993-11-09 1995-06-27 Massachusetts Institute of Technology Oculon Corporation Method and apparatus for detecting cataractogenesis
US5894340A (en) 1995-02-17 1999-04-13 The Regents Of The University Of California Method for quantifying optical properties of the human lens
US6096510A (en) 1995-10-04 2000-08-01 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical detection techniques
JP3594390B2 (ja) * 1995-11-30 2004-11-24 株式会社ニデック 眼科測定装置
JPH09218155A (ja) 1996-02-13 1997-08-19 Bunshi Bio Photonics Kenkyusho:Kk 2次元蛍光寿命測定方法および装置
US5973779A (en) 1996-03-29 1999-10-26 Ansari; Rafat R. Fiber-optic imaging probe
JP3499093B2 (ja) 1996-07-25 2004-02-23 株式会社ニデック 前眼部断面解析装置
DE19649971A1 (de) 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
US5751395A (en) 1997-01-10 1998-05-12 Thall; Edmond H. Retinal diagnostic device
JP3755221B2 (ja) * 1997-01-20 2006-03-15 株式会社デンソー 車両用空調装置
US6144754A (en) 1997-03-28 2000-11-07 Oki Electric Industry Co., Ltd. Method and apparatus for identifying individuals
US6302876B1 (en) 1997-05-27 2001-10-16 Visx Corporation Systems and methods for imaging corneal profiles
US6280386B1 (en) 1997-06-16 2001-08-28 The Research Foundation Of The City University Of New York Apparatus for enhancing the visibility of a luminous object inside tissue and methods for same
US6299307B1 (en) 1997-10-10 2001-10-09 Visx, Incorporated Eye tracking device for laser eye surgery using corneal margin detection
JP3964035B2 (ja) * 1998-03-12 2007-08-22 興和株式会社 眼科装置
EP1227750A4 (en) 1998-04-27 2003-04-16 Katana Technologies Gmbh OPTICAL TRACKING DEVICE
IL125614A (en) * 1998-07-31 2003-01-12 Amiram Grinvald System and method for non-invasive imaging of retinal function
JP3848492B2 (ja) 1998-09-04 2006-11-22 株式会社ニデック 角膜手術装置
US7303281B2 (en) 1998-10-07 2007-12-04 Tracey Technologies, Llc Method and device for determining refractive components and visual function of the eye for vision correction
US6045503A (en) 1999-01-20 2000-04-04 Kamilllo Eisner-Stiftung Method of and apparatus for determining the topology of a cornea
JP3699853B2 (ja) * 1999-02-18 2005-09-28 株式会社ニデック 眼科装置
US6088606A (en) 1999-03-22 2000-07-11 Spectrx, Inc. Method and apparatus for determining a duration of a medical condition
US6275718B1 (en) 1999-03-23 2001-08-14 Philip Lempert Method and apparatus for imaging and analysis of ocular tissue
US7297326B2 (en) * 2000-08-21 2007-11-20 The General Hospital Corporation Ocular diagnosis of Alzheimer's disease
EP2151187A1 (en) 2000-08-21 2010-02-10 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
EP1913866A1 (en) * 2000-08-21 2008-04-23 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
US7350522B2 (en) 2000-10-17 2008-04-01 Sony Corporation Scanning method for applying ultrasonic acoustic data to the human neural cortex
EP1357831A2 (en) 2001-02-09 2003-11-05 Sensomotoric Instruments GmbH Multidimensional eye tracking and position measurement system
EP1420830B1 (en) * 2001-04-27 2011-03-09 The General Hospital Corporation Ocular diagnosis of alzheimer's disease
JP2005505372A (ja) 2001-10-17 2005-02-24 カール・ツアイス・オプサルミック・システムズ・インコーポレーテッド 眼の角膜プロファイルを測定する方法および装置
DE10155464A1 (de) 2001-11-12 2003-05-22 Zeiss Carl Jena Gmbh Beleuchtungseinheit zur Erzeugung von optischen Schnittbildern in transparenten Medien, insbesondere im Auge
US6854847B2 (en) 2001-11-13 2005-02-15 Ming Lai Optical tracking device employing scanning beams on symmetric reference
JP3756127B2 (ja) * 2002-04-19 2006-03-15 株式会社トプコン 眼科撮影装置
WO2003090613A1 (en) 2002-04-26 2003-11-06 Optiscan Pty Ltd Laser scanning confocal microscope with fibre bundle return
US7154111B2 (en) 2002-10-16 2006-12-26 Campbell Science Group, Inc. Cornea characteristics measuring device
WO2004036182A2 (en) 2002-10-17 2004-04-29 Control Delivery Systems, Inc. Methods for monitoring treatment of disease
GB2407378B (en) 2003-10-24 2006-09-06 Lein Applied Diagnostics Ltd Ocular property measuring apparatus and method therefor
US7575321B2 (en) 2003-10-30 2009-08-18 Welch Allyn, Inc. Apparatus and method of diagnosis of optically identifiable ophthalmic conditions
GB2409033C (en) 2003-12-12 2006-05-24 Lein Applied Diagnostics Ltd Extended focal region measuring apparatus and method
JP5085858B2 (ja) 2005-09-27 2012-11-28 株式会社ニデック 眼屈折力測定装置
US7445335B2 (en) 2006-01-20 2008-11-04 Clarity Medical Systems, Inc. Sequential wavefront sensor
HUE031948T2 (en) 2006-04-11 2017-08-28 Cognoptix Inc Eye image analysis
DE102006030382A1 (de) * 2006-06-29 2008-01-03 Carl Zeiss Meditec Ag Verfahren und Vorrichtung zur optischen Detektion am Auge
CA2688811A1 (en) 2007-05-21 2008-11-27 Neuroptix Corporation Ophthalmic formulations of amyloid-beta contrast agents and methods of use thereof
DE102007061987A1 (de) 2007-12-21 2009-06-25 Carl Zeiss Meditec Ag Vorrichtung und Verfahren zum Nachweisen von Molekülen im Auge
CA2718938C (en) 2008-03-27 2016-11-29 Neuroptix Corporation Ocular imaging
GB0903274D0 (en) 2009-02-26 2009-04-08 Edinburgh Instr Fluoreence method and system
EP2420179B1 (en) 2010-08-16 2020-10-07 Cognoptix, Inc. System and method for detecting amyloid proteins

Also Published As

Publication number Publication date
CN102006819A (zh) 2011-04-06
PL2268193T3 (pl) 2017-07-31
US8955969B2 (en) 2015-02-17
CA2718938C (en) 2016-11-29
BRPI0909519B8 (pt) 2021-06-22
KR101603184B1 (ko) 2016-03-14
AU2009229348B2 (en) 2013-09-19
KR20110014573A (ko) 2011-02-11
JP2011515189A (ja) 2011-05-19
BRPI0909519B1 (pt) 2020-03-10
CA2718938A1 (en) 2009-10-01
AU2009229348A1 (en) 2009-10-01
DK2268193T3 (en) 2016-07-04
HK1145958A1 (zh) 2011-05-13
RU2503399C2 (ru) 2014-01-10
RU2010143673A (ru) 2012-05-10
CN102006819B (zh) 2014-03-26
MX2010010402A (es) 2010-12-17
WO2009120349A1 (en) 2009-10-01
ES2584512T3 (es) 2016-09-28
SG188900A1 (en) 2013-04-30
US20110116041A1 (en) 2011-05-19
NZ588811A (en) 2013-08-30
HUE028034T2 (en) 2016-11-28
PT2268193T (pt) 2016-07-08
EP2268193B1 (en) 2016-03-23
EP2268193A1 (en) 2011-01-05

Similar Documents

Publication Publication Date Title
BRPI0909519A2 (pt) fomação de imagem ocular
BRPI0920137A2 (pt) implante ocular
SMT201600424B (it) Emulsione oftalmica
GB2465085B (en) Scleral lens structures
BRPI0916248A2 (pt) lente oftálmica
BRPI0923031A2 (pt) lente oftálmica
IL211275A0 (en) Energized ophthalmic lens
EP2358305A4 (en) INTRAOCULAR LENS OPTICS
BRPI1008891A2 (pt) alinhamento de lente intraocular
BR112012020050A8 (pt) acessório ocular iluminado
HK1171265A1 (zh) 眼鏡片元件
SG10201401070XA (en) An Ocular Lens
EP2268230A4 (en) ADJUSTABLE INTRAOCULAR LENS
EP2287655A4 (en) LENS
FR2913196B1 (fr) Implant oculaire accomodatif
BRPI0916594A2 (pt) aparelho de captura de iamgem de olho facetado
EP2453293A4 (en) OPHTHALMIC LENS
EP2264505A4 (en) GOAL
EP2299297A4 (en) OPTICAL LENS
BR112012001336A2 (pt) tela de visão
GB2451821B (en) Eye bath
FR2931356B1 (fr) Lentille intraoculaire
ES1072688Y (es) "dispositivo de ojete"
DK2252199T3 (da) Snapshotspektralafbildning af øjet
UA17853S (uk) Лінзовий стереоскоп

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: COGNOPTIX. INC. (US)

B25K Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: republication

Owner name: COGNOPTIX, INC. (US)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: A61B 3/117

Ipc: A61B 3/10 (1968.09), A61B 3/117 (1990.01)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/03/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/03/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 14A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2715 DE 17-01-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.