BRPI0821071A2 - Ésteres de ácidos 4-{3[6-amino-9-(3,4-dihidroxi-tetraidro-furan-2-il)-9h-p urin-2il]-prop-2inil}-piperidina-1-carboxílico substituídos como agonistas a2ar - Google Patents

Ésteres de ácidos 4-{3[6-amino-9-(3,4-dihidroxi-tetraidro-furan-2-il)-9h-p urin-2il]-prop-2inil}-piperidina-1-carboxílico substituídos como agonistas a2ar

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Publication number
BRPI0821071A2
BRPI0821071A2 BRPI0821071-3A BRPI0821071A BRPI0821071A2 BR PI0821071 A2 BRPI0821071 A2 BR PI0821071A2 BR PI0821071 A BRPI0821071 A BR PI0821071A BR PI0821071 A2 BRPI0821071 A2 BR PI0821071A2
Authority
BR
Brazil
Prior art keywords
urin
furan
tetrahydro
dihydroxy
prop
Prior art date
Application number
BRPI0821071-3A
Other languages
English (en)
Inventor
Robert Thompson
Anthony Beauglehole
Frank Schmidtmann
Jayson Rieger
Original Assignee
Pgxhealth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pgxhealth Llc filed Critical Pgxhealth Llc
Publication of BRPI0821071A2 publication Critical patent/BRPI0821071A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
BRPI0821071-3A 2007-12-20 2008-12-20 Ésteres de ácidos 4-{3[6-amino-9-(3,4-dihidroxi-tetraidro-furan-2-il)-9h-p urin-2il]-prop-2inil}-piperidina-1-carboxílico substituídos como agonistas a2ar BRPI0821071A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1530307P 2007-12-20 2007-12-20
PCT/US2008/087875 WO2009082720A2 (en) 2007-12-20 2008-12-20 Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9h-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as a2ar agonists

Publications (1)

Publication Number Publication Date
BRPI0821071A2 true BRPI0821071A2 (pt) 2015-06-16

Family

ID=40788895

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0821071-3A BRPI0821071A2 (pt) 2007-12-20 2008-12-20 Ésteres de ácidos 4-{3[6-amino-9-(3,4-dihidroxi-tetraidro-furan-2-il)-9h-p urin-2il]-prop-2inil}-piperidina-1-carboxílico substituídos como agonistas a2ar

Country Status (16)

Country Link
US (2) US8293720B2 (pt)
EP (1) EP2234490A4 (pt)
JP (1) JP2011507907A (pt)
KR (1) KR20100103631A (pt)
CN (1) CN101938906A (pt)
AU (1) AU2008340186B2 (pt)
BR (1) BRPI0821071A2 (pt)
CA (1) CA2710151A1 (pt)
EA (1) EA019244B1 (pt)
IL (1) IL206477A0 (pt)
MX (1) MX2010006645A (pt)
NZ (1) NZ586670A (pt)
SG (1) SG186676A1 (pt)
UA (1) UA100035C2 (pt)
WO (1) WO2009082720A2 (pt)
ZA (1) ZA201004535B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003029264A2 (en) * 2001-10-01 2003-04-10 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
US7576069B2 (en) * 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
NZ585697A (en) * 2004-08-02 2011-12-22 Univ Virginia Patent Found 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
WO2007120972A2 (en) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
CA2871547C (en) 2012-05-25 2021-05-25 Janssen R&D Ireland Uracyl spirooxetane nucleosides
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
CA2880040A1 (en) 2012-08-01 2014-02-06 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as a2a agonists
ES2865402T3 (es) 2012-12-21 2021-10-15 Janssen Biopharma Inc 4'-fluoronucleósidos, 4'-fluoronucleótidos y análogos de los mismos para el tratamiento del VHC
CA3107596A1 (en) 2018-08-23 2020-02-27 Seagen Inc. Anti-tigit antibodies

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232297B1 (en) * 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
WO2003029264A2 (en) * 2001-10-01 2003-04-10 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
AU2003234716A1 (en) * 2002-04-10 2003-10-27 Joel M. Linden Use of a2a adenosine receptor agonists for the treatment of inflammatory diseases
AU2003273096A1 (en) * 2002-10-22 2004-05-13 Korea Research Institute Of Chemical Technology Furan derivatives for preventing and curing osteoporosis and pharmaceutical compositions containing the same
US7576069B2 (en) * 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
NZ585697A (en) * 2004-08-02 2011-12-22 Univ Virginia Patent Found 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
GB0505219D0 (en) * 2005-03-14 2005-04-20 Novartis Ag Organic compounds
WO2007120972A2 (en) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
GB0607951D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
US7589076B2 (en) * 2006-05-18 2009-09-15 Pgx Health, Llc Substituted aryl piperidinylalkynyladenosines as A2AR agonists
US20080262001A1 (en) * 2007-04-23 2008-10-23 Adenosine Therapeutics, Llc Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists

Also Published As

Publication number Publication date
WO2009082720A2 (en) 2009-07-02
UA100035C2 (en) 2012-11-12
CN101938906A (zh) 2011-01-05
CA2710151A1 (en) 2009-07-02
AU2008340186A8 (en) 2010-07-29
US8293720B2 (en) 2012-10-23
SG186676A1 (en) 2013-01-30
EP2234490A2 (en) 2010-10-06
AU2008340186A1 (en) 2009-07-02
AU2008340186B2 (en) 2014-07-10
US20110003765A1 (en) 2011-01-06
WO2009082720A3 (en) 2009-08-27
NZ586670A (en) 2012-10-26
MX2010006645A (es) 2010-10-05
EP2234490A4 (en) 2013-03-27
US20090162292A1 (en) 2009-06-25
JP2011507907A (ja) 2011-03-10
ZA201004535B (en) 2012-09-26
EA019244B1 (ru) 2014-02-28
US8252767B2 (en) 2012-08-28
KR20100103631A (ko) 2010-09-27
IL206477A0 (en) 2010-12-30
EA201001031A1 (ru) 2011-02-28

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