UA100035C2 - Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9h-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as a2ar agonists - Google Patents

Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9h-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as a2ar agonists

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Publication number
UA100035C2
UA100035C2 UAA201009037A UAA201009037A UA100035C2 UA 100035 C2 UA100035 C2 UA 100035C2 UA A201009037 A UAA201009037 A UA A201009037A UA A201009037 A UAA201009037 A UA A201009037A UA 100035 C2 UA100035 C2 UA 100035C2
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UA
Ukraine
Prior art keywords
purin
ynyl
furan
tetrahydro
dihydroxy
Prior art date
Application number
UAA201009037A
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English (en)
Ukrainian (uk)
Inventor
Роберт Томпсон
Энтони Бьюглхоул
Фрэнк Шмидтманн
Джейсон Риджер
Original Assignee
ТРОВИС ФАРМАСЬЮТИКАЛЗ ЭлЭлСи
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Publication of UA100035C2 publication Critical patent/UA100035C2/ru

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    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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Abstract

Данное изобретение относится к замещенным эфирам 4-{3-[6-амино-9-(3,4-дигидрокситетрагидрофуран-2-ил)-9Н-пурин-2-ил]-проп-2-инил}-пиперидин-1-карбоновой кислоты и фармацевтические композиции, содержащие их, которые являются селективными агонистами Ааденозиновых рецепторов (AR).Данные соединения и композиции применяются как фармацевтические препараты.
UAA201009037A 2007-12-20 2008-12-20 Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9h-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as a2ar agonists UA100035C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1530307P 2007-12-20 2007-12-20

Publications (1)

Publication Number Publication Date
UA100035C2 true UA100035C2 (en) 2012-11-12

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ID=40788895

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UAA201009037A UA100035C2 (en) 2007-12-20 2008-12-20 Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9h-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as a2ar agonists

Country Status (16)

Country Link
US (2) US8293720B2 (ru)
EP (1) EP2234490A4 (ru)
JP (1) JP2011507907A (ru)
KR (1) KR20100103631A (ru)
CN (1) CN101938906A (ru)
AU (1) AU2008340186B2 (ru)
BR (1) BRPI0821071A2 (ru)
CA (1) CA2710151A1 (ru)
EA (1) EA019244B1 (ru)
IL (1) IL206477A0 (ru)
MX (1) MX2010006645A (ru)
NZ (1) NZ586670A (ru)
SG (1) SG186676A1 (ru)
UA (1) UA100035C2 (ru)
WO (1) WO2009082720A2 (ru)
ZA (1) ZA201004535B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ556354A (en) * 2001-10-01 2008-10-31 Univ Virginia 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
EP1778712B1 (en) * 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US7576069B2 (en) * 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
WO2007120972A2 (en) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
UY34824A (es) 2012-05-25 2013-11-29 Janssen R & D Ireland Nucleósidos de espirooxetano de uracilo
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
AU2013296420B2 (en) 2012-08-01 2017-12-07 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
KR102327888B1 (ko) 2012-12-21 2021-11-17 얀센 바이오파마, 인코퍼레이트. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
AU2019324170A1 (en) 2018-08-23 2021-02-18 Seagen, Inc. Anti-TIGIT antibodies

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232297B1 (en) * 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
NZ556354A (en) * 2001-10-01 2008-10-31 Univ Virginia 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
JP2006515829A (ja) * 2002-04-10 2006-06-08 ユニバーシティ オブ バージニア パテント ファウンデーション 炎症性疾病の処置のための、ａ２ａアデノシン受容体アゴニストの使用
JP2006515276A (ja) * 2002-10-22 2006-05-25 オスコテック株式会社 骨粗鬆症の予防及び治療効果を有するフラン誘導体並びにこれを含む薬学的組成物
EP1778712B1 (en) 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US7576069B2 (en) * 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
GB0505219D0 (en) * 2005-03-14 2005-04-20 Novartis Ag Organic compounds
WO2007120972A2 (en) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
GB0607951D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
US7589076B2 (en) * 2006-05-18 2009-09-15 Pgx Health, Llc Substituted aryl piperidinylalkynyladenosines as A2AR agonists
US20080262001A1 (en) * 2007-04-23 2008-10-23 Adenosine Therapeutics, Llc Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists

Also Published As

Publication number Publication date
JP2011507907A (ja) 2011-03-10
ZA201004535B (en) 2012-09-26
EA019244B1 (ru) 2014-02-28
CA2710151A1 (en) 2009-07-02
US20110003765A1 (en) 2011-01-06
EP2234490A2 (en) 2010-10-06
NZ586670A (en) 2012-10-26
AU2008340186B2 (en) 2014-07-10
AU2008340186A8 (en) 2010-07-29
WO2009082720A3 (en) 2009-08-27
US20090162292A1 (en) 2009-06-25
US8252767B2 (en) 2012-08-28
SG186676A1 (en) 2013-01-30
EP2234490A4 (en) 2013-03-27
AU2008340186A1 (en) 2009-07-02
MX2010006645A (es) 2010-10-05
KR20100103631A (ko) 2010-09-27
EA201001031A1 (ru) 2011-02-28
IL206477A0 (en) 2010-12-30
BRPI0821071A2 (pt) 2015-06-16
CN101938906A (zh) 2011-01-05
WO2009082720A2 (en) 2009-07-02
US8293720B2 (en) 2012-10-23

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