BRPI0817824B8 - derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmos - Google Patents

derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmos

Info

Publication number
BRPI0817824B8
BRPI0817824B8 BRPI0817824A BRPI0817824A BRPI0817824B8 BR PI0817824 B8 BRPI0817824 B8 BR PI0817824B8 BR PI0817824 A BRPI0817824 A BR PI0817824A BR PI0817824 A BRPI0817824 A BR PI0817824A BR PI0817824 B8 BRPI0817824 B8 BR PI0817824B8
Authority
BR
Brazil
Prior art keywords
useful
treatment
heteroaryl
pharmaceutical compositions
compositions containing
Prior art date
Application number
BRPI0817824A
Other languages
English (en)
Inventor
Moriconi Alessio
Aramini Andrea
Original Assignee
Dompe Farm Spa
Dompe Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Farm Spa, Dompe Spa filed Critical Dompe Farm Spa
Publication of BRPI0817824A2 publication Critical patent/BRPI0817824A2/pt
Publication of BRPI0817824B1 publication Critical patent/BRPI0817824B1/pt
Publication of BRPI0817824B8 publication Critical patent/BRPI0817824B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmos. a presente invenção refere-se a uma nova classe de derivados de (r)-4-(heteroaril) fenilpropiônico de fórmula (i), úteis na inibição de ativação de quimiotática induzida pela fração c5a de complemento. os ditos compostos são úteis no tratamento de patologias dependendo da ativação quimiotática de neutrófilos e monócitos induzida pela fração c5a do complemento. em particular, os compostos da invenção são úteis no tratamento de anemia hemolítica autoimune (ahia), psoríase, penfigoide bulosa, artrite reumatoide, colite ulcerativa, síndrome de distúrbio respiratório agudo, fibrose idiopática, glomerulonefrite e na prevenção e tratamento de dano causado por isquemia e reperfusão.
BRPI0817824A 2007-10-18 2008-10-17 derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmos BRPI0817824B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07020396 2007-10-18
PCT/EP2008/064023 WO2009050258A1 (en) 2007-10-18 2008-10-17 (r)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
BRPI0817824A2 BRPI0817824A2 (pt) 2015-03-31
BRPI0817824B1 BRPI0817824B1 (pt) 2018-12-26
BRPI0817824B8 true BRPI0817824B8 (pt) 2021-05-25

Family

ID=40325746

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0817824A BRPI0817824B8 (pt) 2007-10-18 2008-10-17 derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmos

Country Status (19)

Country Link
US (1) US8133911B2 (pt)
EP (1) EP2201006B1 (pt)
JP (1) JP5374511B2 (pt)
CN (1) CN101827841B (pt)
AT (1) ATE501140T1 (pt)
AU (1) AU2008313669B2 (pt)
BR (1) BRPI0817824B8 (pt)
CA (1) CA2702307C (pt)
DE (1) DE602008005488D1 (pt)
DK (1) DK2201006T3 (pt)
ES (1) ES2361233T3 (pt)
HK (1) HK1146723A1 (pt)
HR (1) HRP20110406T1 (pt)
IL (1) IL205029A (pt)
PL (1) PL2201006T3 (pt)
PT (1) PT2201006E (pt)
RU (1) RU2475486C2 (pt)
SI (1) SI2201006T1 (pt)
WO (1) WO2009050258A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2166006A1 (en) * 2008-09-18 2010-03-24 Dompe' S.P.A. 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
EP3498269A1 (en) * 2017-12-12 2019-06-19 Dompé farmaceutici S.p.A. C5ar inhibitors for use in the treatment of chemotherapy-induced iatrogenic pain
CN115433143B (zh) * 2021-06-03 2023-10-13 中国科学院大连化学物理研究所 一种异噻唑啉酮类化合物的合成方法
EP4397306A1 (en) 2023-01-05 2024-07-10 Dompe' Farmaceutici S.P.A. C5ar1 inhibitors for use in the treatment of ocular mucous membrane pemphigoid and/or oral mucous membrane pemphigoid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9710002A (pt) * 1996-06-27 1999-08-10 Janssen Pharmaceutica Nv N-[4-(heteroarilmetil)fenil]-heteroarilaminas
ITMI20012025A1 (it) * 2001-09-28 2003-03-28 Dompe Spa Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
RU2458051C2 (ru) * 2005-11-24 2012-08-10 ДОМПЕ ФА.Р.МА С.п.А. (r)-арилалкиламинопроизводные и содержащие их фармацевтические композиции

Also Published As

Publication number Publication date
WO2009050258A1 (en) 2009-04-23
DE602008005488D1 (de) 2011-04-21
JP5374511B2 (ja) 2013-12-25
BRPI0817824B1 (pt) 2018-12-26
HK1146723A1 (en) 2011-07-08
AU2008313669B2 (en) 2014-01-16
SI2201006T1 (sl) 2011-07-29
IL205029A0 (en) 2010-11-30
JP2011500643A (ja) 2011-01-06
BRPI0817824A2 (pt) 2015-03-31
RU2475486C2 (ru) 2013-02-20
US20100249198A1 (en) 2010-09-30
PT2201006E (pt) 2011-05-05
PL2201006T3 (pl) 2011-08-31
CN101827841A (zh) 2010-09-08
ATE501140T1 (de) 2011-03-15
ES2361233T3 (es) 2011-06-15
CN101827841B (zh) 2012-11-28
CA2702307A1 (en) 2009-04-23
IL205029A (en) 2014-09-30
CA2702307C (en) 2016-04-05
AU2008313669A1 (en) 2009-04-23
EP2201006B1 (en) 2011-03-09
RU2010119705A (ru) 2011-11-27
DK2201006T3 (da) 2011-06-27
HRP20110406T1 (hr) 2011-06-30
US8133911B2 (en) 2012-03-13
EP2201006A1 (en) 2010-06-30

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: DOMPE FARMACEUTICI S.P.A (IT)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/10/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF