BRPI0807615A2 - compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico - Google Patents
compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínicoInfo
- Publication number
- BRPI0807615A2 BRPI0807615A2 BRPI0807615A BRPI0807615A BRPI0807615A2 BR PI0807615 A2 BRPI0807615 A2 BR PI0807615A2 BR PI0807615 A BRPI0807615 A BR PI0807615A BR PI0807615 A BRPI0807615 A BR PI0807615A BR PI0807615 A2 BRPI0807615 A2 BR PI0807615A2
- Authority
- BR
- Brazil
- Prior art keywords
- quaternary ammonium
- receptor antagonists
- compounds useful
- muscarinic receptor
- diphenylmethyl compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90311007P | 2007-02-23 | 2007-02-23 | |
| PCT/US2008/002321 WO2008103426A1 (en) | 2007-02-23 | 2008-02-21 | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0807615A2 true BRPI0807615A2 (pt) | 2017-10-31 |
| BRPI0807615A8 BRPI0807615A8 (pt) | 2017-12-05 |
Family
ID=39522128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0807615A BRPI0807615A8 (pt) | 2007-02-23 | 2008-02-21 | Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7834185B2 (pt) |
| EP (1) | EP2121594B1 (pt) |
| JP (2) | JP5528817B2 (pt) |
| KR (1) | KR101495708B1 (pt) |
| CN (1) | CN101616893B (pt) |
| AU (1) | AU2008218962B2 (pt) |
| BR (1) | BRPI0807615A8 (pt) |
| CA (1) | CA2675942C (pt) |
| ES (1) | ES2554646T3 (pt) |
| IL (1) | IL199922A (pt) |
| MX (1) | MX2009008527A (pt) |
| RU (1) | RU2452728C2 (pt) |
| WO (1) | WO2008103426A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008103426A1 (en) | 2007-02-23 | 2008-08-28 | Theravance, Inc. | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
| EP2146957B1 (en) | 2007-04-24 | 2013-06-12 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
| RU2480458C2 (ru) * | 2007-09-07 | 2013-04-27 | Тереванс, Инк. | Гуанидинсодержащие соединения, применимые в качестве антагонистов мускариновых рецепторов |
| JP2011506477A (ja) | 2007-12-14 | 2011-03-03 | セラヴァンス， インコーポレーテッド | ムスカリン受容体拮抗薬として有用なアミジン含有化合物 |
| EP3311820A1 (en) * | 2008-02-26 | 2018-04-25 | Sunovion Respiratory Development Inc. | Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations |
| US20100055045A1 (en) | 2008-02-26 | 2010-03-04 | William Gerhart | Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations |
| WO2014007768A1 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dry powder inhaler compositions comprising long acting muscorinic antagonists |
| EP3625232B1 (en) | 2017-05-19 | 2021-06-23 | Council of Scientific and Industrial Research | Substituted methanopyrido [2, 1-a]isoindolones as machr modulators for treating various associated pathophysiological conditions and process for preparation thereof |
| KR20230005938A (ko) | 2020-04-30 | 2023-01-10 | 이도르시아 파마슈티컬스 리미티드 | Ccr6 수용체 조절인자로서의 아제티딘-3-일메탄올 유도체 |
| WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| WO2023072924A1 (en) | 2021-10-26 | 2023-05-04 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| AR127486A1 (es) | 2021-10-28 | 2024-01-31 | Idorsia Pharmaceuticals Ltd | Moduladores del receptor ccr6 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US903110A (en) | 1908-05-23 | 1908-11-03 | Us Electric Signal Company | Track-switch. |
| US4002766A (en) | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | Antiarrhythmia methods |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| US5070087A (en) | 1989-05-08 | 1991-12-03 | A. H. Robins Company, Incorporated | Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents |
| GB8928042D0 (en) * | 1989-12-12 | 1990-02-14 | Pfizer Ltd | Muscarinic receptor antagonists |
| DE60021282T2 (de) | 1999-12-07 | 2006-05-18 | Theravance, Inc., South San Francisco | Carbamat-derivate als muscarin-rezeptor antonisten |
| US6846835B2 (en) | 2000-07-11 | 2005-01-25 | Banyu Pharmaceutical Co., Ltd. | Ester derivatives |
| WO2003035599A1 (en) | 2001-10-26 | 2003-05-01 | Pharmacia & Upjohn Company | Quarternary ammonium compounds and their use as antimuscarinic agents |
| GB0207104D0 (en) * | 2002-03-26 | 2002-05-08 | Pfizer Ltd | Stable hydrate of a muscarinic receptor antagonist |
| ES2206021B1 (es) | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| ES2203327B1 (es) * | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| TW200412945A (en) | 2002-10-25 | 2004-08-01 | Upjohn Co | Quaternary ammonium compounds |
| TW200800953A (en) * | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
| WO2004089892A2 (en) * | 2003-04-01 | 2004-10-21 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 andrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
| TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
| AR044851A1 (es) * | 2003-06-24 | 2005-10-05 | Novartis Ag | Compuestos heterociclicos, antagonistas del receptor m3 muscarinico |
| TW200530226A (en) * | 2003-12-03 | 2005-09-16 | Glaxo Group Ltd | Novel M3 muscarinic acetylcholine receptor antagonists |
| US7250414B2 (en) * | 2004-03-11 | 2007-07-31 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
| AR048976A1 (es) * | 2004-05-28 | 2006-06-14 | Glaxo Group Ltd | Compuesto derivado de alcohol terciario de 8-azoniabiciclo(3.2.1)octano, composicion farmaceutica que lo comprende y su uso para preparar esta ultima |
| KR20070090915A (ko) * | 2004-12-23 | 2007-09-06 | 키에시 파르마슈티시 엣스. 피. 에이. | 항 무스카린성 활성을 가진 아졸유도체 |
| GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428416D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| WO2007018508A1 (en) * | 2005-07-28 | 2007-02-15 | Glaxo Group Limited | Novel m3 muscarinic acetycholine receptor antagonists |
| JP2009504768A (ja) | 2005-08-18 | 2009-02-05 | グラクソ グループ リミテッド | ムスカリン性アセチルコリン受容体アンタゴニスト |
| WO2008103426A1 (en) | 2007-02-23 | 2008-08-28 | Theravance, Inc. | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
| EP2146957B1 (en) | 2007-04-24 | 2013-06-12 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
| RU2480458C2 (ru) | 2007-09-07 | 2013-04-27 | Тереванс, Инк. | Гуанидинсодержащие соединения, применимые в качестве антагонистов мускариновых рецепторов |
| JP2011506477A (ja) | 2007-12-14 | 2011-03-03 | セラヴァンス， インコーポレーテッド | ムスカリン受容体拮抗薬として有用なアミジン含有化合物 |
-
2008
- 2008-02-21 WO PCT/US2008/002321 patent/WO2008103426A1/en active Application Filing
- 2008-02-21 JP JP2009550918A patent/JP5528817B2/ja not_active Expired - Fee Related
- 2008-02-21 US US12/070,780 patent/US7834185B2/en not_active Expired - Fee Related
- 2008-02-21 BR BRPI0807615A patent/BRPI0807615A8/pt not_active Application Discontinuation
- 2008-02-21 ES ES08725911.5T patent/ES2554646T3/es active Active
- 2008-02-21 AU AU2008218962A patent/AU2008218962B2/en not_active Ceased
- 2008-02-21 CN CN200880005529.5A patent/CN101616893B/zh not_active Expired - Fee Related
- 2008-02-21 KR KR1020097019812A patent/KR101495708B1/ko active IP Right Grant
- 2008-02-21 RU RU2009135389/04A patent/RU2452728C2/ru active
- 2008-02-21 CA CA2675942A patent/CA2675942C/en not_active Expired - Fee Related
- 2008-02-21 EP EP08725911.5A patent/EP2121594B1/en not_active Not-in-force
- 2008-02-21 MX MX2009008527A patent/MX2009008527A/es active IP Right Grant
-
2009
- 2009-07-16 IL IL199922A patent/IL199922A/en active IP Right Grant
-
2010
- 2010-10-06 US US12/898,858 patent/US8592453B2/en active Active
- 2010-10-06 US US12/898,861 patent/US8378121B2/en active Active
-
2013
- 2013-10-22 US US14/059,755 patent/US8802856B2/en not_active Expired - Fee Related
-
2014
- 2014-02-25 JP JP2014033710A patent/JP2014098031A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP5528817B2 (ja) | 2014-06-25 |
| EP2121594B1 (en) | 2015-10-21 |
| US20140051864A1 (en) | 2014-02-20 |
| US20080207736A1 (en) | 2008-08-28 |
| CN101616893A (zh) | 2009-12-30 |
| AU2008218962A1 (en) | 2008-08-28 |
| US20110021787A1 (en) | 2011-01-27 |
| JP2014098031A (ja) | 2014-05-29 |
| MX2009008527A (es) | 2009-08-27 |
| IL199922A (en) | 2014-08-31 |
| KR20090117948A (ko) | 2009-11-16 |
| US8378121B2 (en) | 2013-02-19 |
| CN101616893B (zh) | 2014-01-29 |
| CA2675942A1 (en) | 2008-02-28 |
| CA2675942C (en) | 2016-04-12 |
| WO2008103426A1 (en) | 2008-08-28 |
| IL199922A0 (en) | 2010-04-15 |
| RU2452728C2 (ru) | 2012-06-10 |
| KR101495708B1 (ko) | 2015-02-25 |
| US20110020231A1 (en) | 2011-01-27 |
| ES2554646T3 (es) | 2015-12-22 |
| US8802856B2 (en) | 2014-08-12 |
| US8592453B2 (en) | 2013-11-26 |
| BRPI0807615A8 (pt) | 2017-12-05 |
| EP2121594A1 (en) | 2009-11-25 |
| JP2010519299A (ja) | 2010-06-03 |
| AU2008218962B2 (en) | 2013-03-14 |
| US7834185B2 (en) | 2010-11-16 |
| RU2009135389A (ru) | 2011-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: THERAVANCE BIOPHARMA RANDD IP, LLC (US) |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |