BRPI0804889A8 - Processo de produção de conjugados de interferon com óxidos de polialquilenos e seus usos - Google Patents
Processo de produção de conjugados de interferon com óxidos de polialquilenos e seus usosInfo
- Publication number
- BRPI0804889A8 BRPI0804889A8 BRPI0804889A BRPI0804889A BRPI0804889A8 BR PI0804889 A8 BRPI0804889 A8 BR PI0804889A8 BR PI0804889 A BRPI0804889 A BR PI0804889A BR PI0804889 A BRPI0804889 A BR PI0804889A BR PI0804889 A8 BRPI0804889 A8 BR PI0804889A8
- Authority
- BR
- Brazil
- Prior art keywords
- polyalkylene oxides
- conjugates
- production
- interferon
- interferon conjugates
- Prior art date
Links
- 102000014150 Interferons Human genes 0.000 title abstract 4
- 108010050904 Interferons Proteins 0.000 title abstract 4
- 229940079322 interferon Drugs 0.000 title abstract 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 208000007766 Kaposi sarcoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCESSO DE PRODUÇÃO DE CONJUGADOS DE INTERFERON COM ÓXIDOS DE POLIALQUILENOS E SEUS USOS. A presente invenção descreve um processo de produção de conjugados de interferon com óxidos de polialquileno, no qual a composição farmacêutica, ou perfil de conjugação polímero-proteína é advinda de pH levemente básico, (7,2- 8,0). A presente invenção refere-se ainda à aplicação de tais conjugados na área farmacêutica. Tais conjugados de interferon com óxidos de polialquileno são utilizados como medicamentos no tratamento de hepatite B e C, bem como no combate de neoplasias, por exemplo, sarcoma de Kaposis e alguns tipos de leucemia e melanomas malignos.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0804889-4A BRPI0804889B1 (pt) | 2008-08-22 | 2008-08-22 | Processo de produção de conjugados de interferon com óxidos de polialquilenos e seus usos |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0804889-4A BRPI0804889B1 (pt) | 2008-08-22 | 2008-08-22 | Processo de produção de conjugados de interferon com óxidos de polialquilenos e seus usos |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0804889A2 BRPI0804889A2 (pt) | 2010-07-27 |
| BRPI0804889A8 true BRPI0804889A8 (pt) | 2017-07-25 |
| BRPI0804889B1 BRPI0804889B1 (pt) | 2021-05-25 |
Family
ID=42352821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0804889-4A BRPI0804889B1 (pt) | 2008-08-22 | 2008-08-22 | Processo de produção de conjugados de interferon com óxidos de polialquilenos e seus usos |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BRPI0804889B1 (pt) |
-
2008
- 2008-08-22 BR BRPI0804889-4A patent/BRPI0804889B1/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0804889B1 (pt) | 2021-05-25 |
| BRPI0804889A2 (pt) | 2010-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: C07K 14/555 (2006.01), C07K 14/56 (2006.01), A61K |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/08/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |