BRPI0801367B8 - material conjugado e aparelho médico implantável com revestimento fornecido pelo material conjugado - Google Patents

material conjugado e aparelho médico implantável com revestimento fornecido pelo material conjugado

Info

Publication number
BRPI0801367B8
BRPI0801367B8 BRPI0801367A BRPI0801367A BRPI0801367B8 BR PI0801367 B8 BRPI0801367 B8 BR PI0801367B8 BR PI0801367 A BRPI0801367 A BR PI0801367A BR PI0801367 A BRPI0801367 A BR PI0801367A BR PI0801367 B8 BRPI0801367 B8 BR PI0801367B8
Authority
BR
Brazil
Prior art keywords
comb
antithrombotic
coating
conjugate
composite material
Prior art date
Application number
BRPI0801367A
Other languages
English (en)
Inventor
Z Zhao Jonathon
Original Assignee
Cordis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordis Corp filed Critical Cordis Corp
Publication of BRPI0801367A2 publication Critical patent/BRPI0801367A2/pt
Publication of BRPI0801367B1 publication Critical patent/BRPI0801367B1/pt
Publication of BRPI0801367B8 publication Critical patent/BRPI0801367B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F216/04—Acyclic compounds
    • C08F216/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/04—Homopolymers or copolymers of esters
    • C09D133/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Abstract

revestimento para dispositivo médico tendo conjugado antitrombótico. a presente invenção refere-se a processos para produção de conjugado antitrombótico do tipo pente, no qual substancialmente todas as cadeias laterais de poli (álcool vinílico) (pva) são estendidas por polimerização por abertura de anel, para formar um copolímero, no qual substancialmente todas as partes terminais são conjugadas a uma molécula antitrombótica. além disso, um processo é proporcionado para aplicar um revestimento, compreendendo um conjugado antitrombótico do tipo pente, a pelo menos uma parte de um dispositivo implantável, para impedir ou reduzir a formação de trombose na superfície do dispositivo. uma primeira ou subcamada do revestimento é preparada por mistura de um material polimérico e um agente biologicamente ativo com um solvente, formando, desse modo, uma solução homogênea. uma segunda ou camada externa, compreendendo um conjugado antitrombótico do tipo pente, pode ser aplicada nas camadas internas contendo fármaco, usando, por exemplo, um processo de revestimento por imersão ou revestimento por aspersão. alternativamente, o conjugado antitrombótico do tipo pente pode ser usado como um material matriz, para encapsular um agente farmacêutico, para formar microsferas ou nanosferas antes de depositá-las em um dispositivo médico.
BRPI0801367A 2007-04-30 2008-04-30 material conjugado e aparelho médico implantável com revestimento fornecido pelo material conjugado BRPI0801367B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/741,997 US8383156B2 (en) 2007-04-30 2007-04-30 Coating for a medical device having an anti-thrombotic conjugate
US11/741,997 2007-04-30

Publications (3)

Publication Number Publication Date
BRPI0801367A2 BRPI0801367A2 (pt) 2008-12-16
BRPI0801367B1 BRPI0801367B1 (pt) 2020-03-10
BRPI0801367B8 true BRPI0801367B8 (pt) 2021-06-22

Family

ID=39645271

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0801367A BRPI0801367B8 (pt) 2007-04-30 2008-04-30 material conjugado e aparelho médico implantável com revestimento fornecido pelo material conjugado

Country Status (12)

Country Link
US (2) US8383156B2 (pt)
EP (4) EP2272549B1 (pt)
JP (1) JP5456272B2 (pt)
KR (1) KR101443581B1 (pt)
CN (1) CN101297982B (pt)
AU (1) AU2008201646B8 (pt)
BR (1) BRPI0801367B8 (pt)
CA (1) CA2630091C (pt)
ES (3) ES2399184T3 (pt)
IL (1) IL190791A (pt)
MX (1) MX2008005652A (pt)
RU (1) RU2472529C2 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090281059A1 (en) * 2007-02-21 2009-11-12 Robert Falotico Coating for a medical device having an anti-thrombotic conjugate
US20090018646A1 (en) * 2007-07-10 2009-01-15 Zhao Jonathon Z Coating Employing an Anti-Thrombotic Conjugate
EP2209420A4 (en) 2007-10-09 2014-01-22 Univ St Louis IMAGING PARTICLES
US9468607B2 (en) 2007-10-09 2016-10-18 Washington University Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
CA2758322C (en) 2009-04-10 2019-04-02 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
GB0922066D0 (en) 2009-12-17 2010-02-03 Univ Belfast Modulator
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
US9764043B2 (en) 2009-12-17 2017-09-19 Washington University Antithrombotic nanoparticle
CA2787002A1 (en) * 2010-01-25 2011-07-28 Concept Medical Research Private Limited A method and an insertable medical device for delivering one or more pro-healing agents to a target site within a blood vessel post-deployment of a stent
AU2011239414A1 (en) 2010-04-15 2012-11-08 The Washington University Prodrug compositions, prodrug nanoparticles, and methods of use thereof
CN102379762B (zh) * 2011-08-02 2015-03-25 上海微创医疗器械（集团）有限公司 一种带凹槽的生物可降解支架及其制备方法
TWI487543B (zh) * 2011-12-12 2015-06-11 Ind Tech Res Inst 梳狀結構高分子、醫療裝置的改質方法及醫療裝置
US20130303983A1 (en) * 2012-05-09 2013-11-14 Cook Medical Technologies Llc Coated medical devices including a water-insoluble therapeutic agent
ES2881278T3 (es) * 2013-04-26 2021-11-29 Biointeractions Ltd Recubrimientos bioactivos
CN105899244B (zh) * 2013-11-14 2019-02-19 pfm医用钛有限公司 具有抗血栓形成的涂层的聚氨酯
CN105744967B (zh) * 2013-11-28 2018-12-25 东丽株式会社 抗血栓性材料
EP3028719A1 (en) * 2014-12-01 2016-06-08 Lanxess Inc. Polymer-drug conjugate based on a polyisoolefin-based copolymer
KR20170133321A (ko) * 2015-03-31 2017-12-05 도레이 카부시키가이샤 항 혈전성 금속 재료
US10285692B2 (en) * 2015-08-31 2019-05-14 Ethicon Llc Adjuncts for surgical devices including agonists and antagonists
US10569071B2 (en) 2015-08-31 2020-02-25 Ethicon Llc Medicant eluting adjuncts and methods of using medicant eluting adjuncts
JP6855440B2 (ja) * 2016-02-29 2021-04-07 丸善石油化学株式会社 コポリマー、これを利用する抗血栓コーティング剤及び医療用具
US9861410B2 (en) 2016-05-06 2018-01-09 Medos International Sarl Methods, devices, and systems for blood flow
WO2018053276A1 (en) 2016-09-16 2018-03-22 Glycologix, Llc Sulfated glycosaminoglycan biomaterials as proteoglycan mimics
CN107519544A (zh) * 2017-08-28 2017-12-29 武汉杨森生物技术有限公司 复合肝素抗凝涂层用微球及制备方法与应用
RU2686747C1 (ru) * 2018-11-08 2019-04-30 Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) Способ получения биодеградируемого полимерного покрытия на основе полилактида на проволоке TiNbTaZr
AU2020230552A1 (en) * 2019-03-04 2021-10-07 Global Surgical Innovations Pty Ltd An attachment means for attaching a medical device to tissue, a system for attaching a medical device to tissue, a medical device having an attachment means, a method of attaching a medical device to tissue, and a method of manufacturing an attachment means.
CN111748053A (zh) * 2020-05-18 2020-10-09 武汉杨森生物技术有限公司 一种抗凝血共聚物的制备方法及其应用
CN114773530B (zh) * 2022-03-29 2023-05-12 河南驼人医疗器械研究院有限公司 一种具有抗凝血功能的聚合物乳液及其制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1169888B (it) * 1983-10-25 1987-06-03 Italfarmaco Spa Glicosaminoglicani modificati dotati di attivita' antitrombotica
US5525348A (en) * 1989-11-02 1996-06-11 Sts Biopolymers, Inc. Coating compositions comprising pharmaceutical agents
US5837313A (en) * 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US5855618A (en) * 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US6174326B1 (en) 1996-09-25 2001-01-16 Terumo Kabushiki Kaisha Radiopaque, antithrombogenic stent and method for its production
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
KR100314496B1 (ko) * 1998-05-28 2001-11-22 윤동진 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도
NO984144L (no) * 1998-09-09 2000-03-10 Carmeda Ab Sammensetning som omfatter heparin som et ikke-trombogent overflatebelegg
NO984143L (no) * 1998-09-09 2000-03-10 Norsk Hydro As Ny prosess for å fremstille overflatemodifiserende stoffer
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6159531A (en) * 1999-08-30 2000-12-12 Cardiovasc, Inc. Coating having biological activity and medical implant having surface carrying the same and method
US6764507B2 (en) * 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
KR100378109B1 (ko) * 2000-10-24 2003-03-29 주식회사 메디프렉스 소수성 다중복합 헤파린 결합체, 그의 제조방법 및 용도
US7771468B2 (en) * 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
CN100366289C (zh) * 2001-09-12 2008-02-06 维日克斯医药公司 具有固定的血小板结合剂的血管闭塞固相试剂
US6767405B2 (en) * 2002-07-10 2004-07-27 Carmeda Ab Apparatus and process for coating articles
US7438925B2 (en) 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
US6702850B1 (en) * 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis
US7169179B2 (en) * 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
WO2005097223A1 (en) 2004-03-26 2005-10-20 Surmodics, Inc. Composition and method for preparing biocompatible surfaces
EP1879552B1 (en) 2005-03-14 2016-02-17 Biotegra, Inc. Drug delivery compositions comprising a polyelectrolyte complex within a polymeric matrix

Also Published As

Publication number Publication date
EP2269666A2 (en) 2011-01-05
IL190791A (en) 2015-02-26
ES2399186T3 (es) 2013-03-26
BRPI0801367A2 (pt) 2008-12-16
EP2272548A3 (en) 2011-02-23
US8383156B2 (en) 2013-02-26
MX2008005652A (es) 2009-03-02
CN101297982A (zh) 2008-11-05
CN101297982B (zh) 2013-08-14
BRPI0801367B1 (pt) 2020-03-10
JP2009011814A (ja) 2009-01-22
KR101443581B1 (ko) 2014-10-14
EP2272549A3 (en) 2011-02-23
AU2008201646A8 (en) 2013-09-12
RU2472529C2 (ru) 2013-01-20
CA2630091C (en) 2016-07-05
AU2008201646B8 (en) 2013-09-12
EP1987851A2 (en) 2008-11-05
EP2272548B1 (en) 2013-01-16
EP2269666A3 (en) 2011-02-23
AU2008201646A1 (en) 2008-11-13
US20130172986A1 (en) 2013-07-04
RU2008117191A (ru) 2009-11-10
IL190791A0 (en) 2008-12-29
AU2008201646B2 (en) 2013-08-29
CA2630091A1 (en) 2008-10-30
EP1987851A3 (en) 2008-12-24
JP5456272B2 (ja) 2014-03-26
ES2399185T3 (es) 2013-03-26
EP2272549A2 (en) 2011-01-12
EP2272548A2 (en) 2011-01-12
EP2272549B1 (en) 2013-01-16
KR20080097155A (ko) 2008-11-04
EP2269666B1 (en) 2013-01-16
ES2399184T3 (es) 2013-03-26
US8911492B2 (en) 2014-12-16
US20080269875A1 (en) 2008-10-30

Similar Documents

Publication Publication Date Title
BRPI0801367B8 (pt) material conjugado e aparelho médico implantável com revestimento fornecido pelo material conjugado
EP1961434A3 (en) A Coating for a Medical Device Having an Anti-Thrombotic Conjugate
AR056554A1 (es) Formulacion de farmaco de molecula pequena de liberacion sostenida
Chunder et al. Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties
WO2005117843A3 (en) Sustained release preparations
WO2003055475A8 (en) Controlled release pharmaceutical formulation containing venlafaxine
EP3235538A1 (en) Microneedle patch, method for manufacturing same, and apparatus for manufacturing microneedle array
WO2003047636A3 (en) Microbe-resistant medical device, microbe-resistant polymeric coating and methods for producing same
DE69921158T2 (de) Gele und mehrschichtige oberflächenstrukturen aus boronsäurehaltigen polymeren
JP2007502139A5 (pt)
DE69939019D1 (de) Zusammensetzungen für die schnelle und nicht-irritierende transdermale verabreichung von pharmazeutika and verfahren zur formuliering davon und ihren verabreichung
AR040684A1 (es) Forma de dosificacion solida recubierta y metodo de preparacion de la misma
WO2005091835A3 (en) A method and system for making a coated medical device
BR122016021907B8 (pt) conjugado de insulina-peg, microesfera de poli(lactídioco-glicolídio), formulação de liberação de droga, e uso
BRPI0517051A (pt) dispersão de microcápsula, processo para a preparação de uma dispersão de microcápsula, e, microcápsulas
DK1663217T3 (da) Faste dispersioner indeholdende tacrolimus
EP2277564A3 (en) An anti-thrombotic coating for a medical device
WO2009091812A3 (en) Devices and methods for elution of nucleic acid delivery complexes
DE102017212974A1 (de) Verfahren zur Beschichtung und Werkstück
Campos et al. Layer-by-layer films containing emodin or emodin encapsulated in liposomes for transdermal applications
WO2009115524A1 (de) Vorrichtung zum besprühen, verfahren dazu sowie organisches elektronisches bauelement
ATE214598T1 (de) Multipartikuläre pharmazeutische form mit gesteuerter und gepulster wirkstoffabgabe und verfahren zu deren herstellung
DE602005020789D1 (de) Herstellung von hydrophilen überzügen mit einer 1,3-dioxolan-verbindung
EP1087759B1 (de) Verfahren zur herstellung eines aus einzelnen schichten bestehenden laminats
ATE326293T1 (de) Herstellung von superabsorbierendem material mittels plasmamodifizierung

Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A61F 2/82 , A61L 33/10 , A61L 31/10 , A61L 31/16

Ipc: A61L 31/10 (2000.01), A61L 31/16 (2000.01), A61L 3

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/03/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/04/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.