BRPI0721707A2 - estruturas de cristal de fragmentos de neuropilina e complexos de neuropilina-anticorpo - Google Patents
estruturas de cristal de fragmentos de neuropilina e complexos de neuropilina-anticorpo Download PDFInfo
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- BRPI0721707A2 BRPI0721707A2 BRPI0721707-2A BRPI0721707A BRPI0721707A2 BR PI0721707 A2 BRPI0721707 A2 BR PI0721707A2 BR PI0721707 A BRPI0721707 A BR PI0721707A BR PI0721707 A2 BRPI0721707 A2 BR PI0721707A2
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- vegf
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2007/069185 WO2008143666A2 (en) | 2007-05-17 | 2007-05-17 | Crystal structures of neuropilin fragments and neuropilin-antibody complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0721707A2 true BRPI0721707A2 (pt) | 2013-01-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| BRPI0721707-2A BRPI0721707A2 (pt) | 2007-05-17 | 2007-05-17 | estruturas de cristal de fragmentos de neuropilina e complexos de neuropilina-anticorpo |
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| UY31800A (es) * | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
| EP2582729A4 (en) | 2010-06-18 | 2014-05-28 | Hoffmann La Roche | ANTI-AXL ANTIBODIES AND METHOD FOR THEIR USE |
| EP2686020B1 (en) | 2011-03-17 | 2017-02-22 | The University of Birmingham | Re-directed immunotherapy |
| ES2992753T3 (en) | 2012-08-24 | 2024-12-17 | Univ California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
| CN103992376B (zh) * | 2013-02-18 | 2017-05-17 | 上海市第一人民医院 | 一种抑制新生血管的小肽及其应用 |
| CN103992377B (zh) * | 2013-02-18 | 2017-05-17 | 上海市第一人民医院 | 一种抑制新生血管的小肽及其应用 |
| DK2970921T3 (en) | 2013-03-15 | 2019-01-14 | Atyr Pharma Inc | Histidyl-tRNA synthetase-Fc conjugates |
| AU2015270925A1 (en) | 2014-06-02 | 2016-12-22 | Children's Medical Center Corporation | Methods and compositions for immunomodulation |
| CN113980116A (zh) | 2014-09-05 | 2022-01-28 | Rsem有限合伙公司 | 用于治疗和预防炎症的组合物和方法 |
| KR102293755B1 (ko) | 2016-01-06 | 2021-08-24 | 오더-메이드 메디컬 리서치 인코포레이티드 | 고친화성 항vegf 항체 |
| US11008387B2 (en) | 2016-01-06 | 2021-05-18 | Order-Made Medical Research Inc. | Antibody inhibiting binding of VEGF to NRP1 |
| KR20240113990A (ko) | 2016-06-27 | 2024-07-23 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 암 치료 조합 |
| JOP20190134A1 (ar) | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
| WO2018195338A1 (en) | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
| CN111051346A (zh) | 2017-05-31 | 2020-04-21 | 斯特库伯株式会社 | 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法 |
| KR20200026209A (ko) * | 2017-06-06 | 2020-03-10 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1 또는 btn1a1-리간드에 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법 |
| WO2019195770A1 (en) * | 2018-04-06 | 2019-10-10 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| CN113226472B (zh) | 2018-12-17 | 2025-01-28 | 雷维托普有限公司 | 双免疫细胞衔接物 |
| TWI859339B (zh) | 2019-09-24 | 2024-10-21 | 德商百靈佳殷格翰國際股份有限公司 | 抗nrp1a抗體及其用於治療眼或眼部疾病之用途 |
| AU2020358854A1 (en) | 2019-10-03 | 2022-05-26 | Atyr Pharma, Inc. | Compositions and methods comprising anti-NRP2 antibodies |
| GB202207116D0 (en) * | 2022-05-16 | 2022-06-29 | Quadram Inst Bioscience | Method and Compositions for Tumorigenesis Inhibition |
| CN114949224B (zh) * | 2022-06-06 | 2023-03-14 | 山东大学第二医院 | Nrp2激动剂在制备复发性流产治疗药物中的应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5750373A (en) | 1990-12-03 | 1998-05-12 | Genentech, Inc. | Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants |
| CA2345497A1 (en) | 1988-10-28 | 1990-04-28 | Genentech, Inc. | Growth hormone variants and method for forming growth hormone variants |
| ATE102631T1 (de) | 1988-11-11 | 1994-03-15 | Medical Res Council | Klonierung von immunglobulin sequenzen aus den variabelen domaenen. |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5658727A (en) | 1991-04-10 | 1997-08-19 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| JP3398382B2 (ja) | 1992-10-28 | 2003-04-21 | ジェネンテク，インコーポレイテッド | 血管内皮細胞増殖因子アンタゴニスト |
| JP3720353B2 (ja) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| PT971959E (pt) | 1997-04-07 | 2006-05-31 | Genentech Inc | Anticorpos humanizados e metodos para formar anticorpos humanizados |
| US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
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- 2007-05-17 WO PCT/US2007/069185 patent/WO2008143666A2/en not_active Ceased
- 2007-05-17 CA CA002687556A patent/CA2687556A1/en not_active Abandoned
- 2007-05-17 AU AU2007353779A patent/AU2007353779B2/en not_active Ceased
- 2007-05-17 CN CN2007800537931A patent/CN101743253B/zh not_active Expired - Fee Related
-
2009
- 2009-11-08 IL IL201983A patent/IL201983A/en not_active IP Right Cessation
-
2012
- 2012-03-12 RU RU2012109383/10A patent/RU2012109383A/ru not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2158215B1 (en) | 2015-04-22 |
| IL201983A0 (en) | 2010-06-16 |
| KR101523788B1 (ko) | 2015-06-26 |
| WO2008143666A3 (en) | 2009-02-05 |
| AU2007353779B2 (en) | 2013-11-07 |
| WO2008143666A2 (en) | 2008-11-27 |
| ES2541051T3 (es) | 2015-07-15 |
| JP2010530359A (ja) | 2010-09-09 |
| RU2012109383A (ru) | 2013-09-20 |
| IL201983A (en) | 2015-03-31 |
| US20120322989A1 (en) | 2012-12-20 |
| CA2687556A1 (en) | 2008-11-27 |
| EP2158215A2 (en) | 2010-03-03 |
| HK1144580A1 (en) | 2011-02-25 |
| US8466264B2 (en) | 2013-06-18 |
| US8318163B2 (en) | 2012-11-27 |
| KR20100020967A (ko) | 2010-02-23 |
| CN101743253B (zh) | 2013-05-08 |
| AU2007353779A1 (en) | 2008-11-27 |
| MX2009012282A (es) | 2009-11-25 |
| US20100150919A1 (en) | 2010-06-17 |
| CN101743253A (zh) | 2010-06-16 |
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