BRPI0719708A2 - Novos moduladores de proteína quinase e seus usos terapêuticos. - Google Patents

Novos moduladores de proteína quinase e seus usos terapêuticos.

Info

Publication number
BRPI0719708A2
BRPI0719708A2 BRPI0719708-0A2A BRPI0719708A BRPI0719708A2 BR PI0719708 A2 BRPI0719708 A2 BR PI0719708A2 BR PI0719708 A BRPI0719708 A BR PI0719708A BR PI0719708 A2 BRPI0719708 A2 BR PI0719708A2
Authority
BR
Brazil
Prior art keywords
protein kinase
therapeutic uses
new protein
kinase modulators
modulators
Prior art date
Application number
BRPI0719708-0A2A
Other languages
English (en)
Portuguese (pt)
Inventor
Hadas Reuveni
Alexander Levitzki
Lilach Steiner
Revital Sasson
Iris Ben-David
Avi Weissberg
Original Assignee
Novotyr Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novotyr Therapeutics Ltd filed Critical Novotyr Therapeutics Ltd
Publication of BRPI0719708A2 publication Critical patent/BRPI0719708A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
BRPI0719708-0A2A 2006-12-04 2007-12-04 Novos moduladores de proteína quinase e seus usos terapêuticos. BRPI0719708A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87251106P 2006-12-04 2006-12-04
PCT/IL2007/001494 WO2008068751A1 (en) 2006-12-04 2007-12-04 Novel protein kinase modulators and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
BRPI0719708A2 true BRPI0719708A2 (pt) 2014-02-18

Family

ID=39111493

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0719708-0A2A BRPI0719708A2 (pt) 2006-12-04 2007-12-04 Novos moduladores de proteína quinase e seus usos terapêuticos.

Country Status (8)

Country Link
US (1) US8058309B2 (https=)
EP (1) EP2125712B1 (https=)
JP (1) JP2010511694A (https=)
CN (1) CN101652345A (https=)
AU (1) AU2007330333A1 (https=)
BR (1) BRPI0719708A2 (https=)
CA (1) CA2671632A1 (https=)
WO (1) WO2008068751A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2758016A1 (en) * 2008-06-05 2009-12-10 Novotyr Therapeutics Ltd. Novel modulators of protein kinase signaling
ES2566673T3 (es) 2010-12-27 2016-04-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Derivados 2-(2-feniletenilo)-1,3-benzotiazol útiles para el tratamiento del cáncer
WO2012117396A1 (en) 2011-03-01 2012-09-07 Novotyr Therapeutics Ltd Tyrphostin derivative in combination with cytotoxic compounds for treating cancer
EP3021944B1 (en) * 2013-07-14 2018-12-19 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Igf-1r signaling pathway inhibitors useful in the treatment of neurodegenerative diseases
CN107250108B (zh) * 2015-02-05 2020-11-27 特尔诺沃有限公司 用于治疗癌症的irs/stat3双重调节剂与抗癌剂的组合
WO2019097503A1 (en) 2017-11-16 2019-05-23 Tyrnovo Ltd. Combinations of irs/stat3 dual modulators and anti pd-1/pd-l1 antibodies for treating cancer
WO2019246273A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor
CN115466205B (zh) * 2021-11-04 2023-10-24 特尔诺沃有限公司 分离的3-（2-溴-3,4-二羟基-苯基）-n-（3,4,5-三羟基-苄基）-硫代丙烯酰胺的反式异构体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217999A (en) 1987-12-24 1993-06-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Styryl compounds which inhibit EGF receptor protein tyrosine kinase
WO1995024190A2 (en) * 1994-03-07 1995-09-14 Sugen, Inc. Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
US20040197335A1 (en) * 2001-06-14 2004-10-07 Shimon Slavin Non-myeloablative tolerogenic treatment with tyrphostins
CA2466928A1 (en) * 2001-12-10 2003-07-03 Yansheng Du Treatment of neurodegenerative and cardiovascular disorders
WO2003101927A1 (en) * 2002-05-31 2003-12-11 Proteotech, Inc. Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease

Also Published As

Publication number Publication date
US20100056635A1 (en) 2010-03-04
AU2007330333A1 (en) 2008-06-12
CA2671632A1 (en) 2008-06-12
EP2125712A1 (en) 2009-12-02
EP2125712B1 (en) 2014-07-23
CN101652345A (zh) 2010-02-17
US8058309B2 (en) 2011-11-15
JP2010511694A (ja) 2010-04-15
WO2008068751A1 (en) 2008-06-12

Similar Documents

Publication Publication Date Title
BRPI0718182A2 (pt) Oligorribonucleotídeos e seus usos.
EP2061765A4 (en) SERIN THREONINE PROTEIN KINASE AND PARP MODULATORS
BRPI0818690A2 (pt) Derivados de quinazolinediona, sua preparação e seus usos terapêuticos.
BRPI0814267A2 (pt) Agentes citotóxicos compreendendo novos derivados de tomaicmicina e o seu uso terapêutico.
EP2173377A4 (en) ANTIBODY ENDOSTATIN FUSION PROTEIN AND ITS VARIATIONS
SI3424932T1 (sl) Boronoftalidi za terapevtsko uporabo
DK1888123T3 (da) Celleterapi til øjendegeneration
BRPI0717317A2 (pt) Modularoes da proteína cinase triazalopiridazina
BRPI0819909A2 (pt) anticorpos antimesotelina e usos dos mesmos
BRPI0717320A2 (pt) Triazóis bicíclicos como moduladores de proteína cinase
ATE525088T1 (de) Kombinationstherapie
BRPI0809583A2 (pt) polipeptídeos fgf-21 modificados e seus usos
BRPI0812360A2 (pt) Compostos moduladores de quinase heterocíclica e método de modulação da atividade de uma proteína tirosina quinase
BRPI0716549A2 (pt) moduladores de quinase associada de interleucina-1
DE502005007353D1 (de) Zervikale zwischenwirbelprothese
BRPI0816064A2 (pt) Inibidores da atividade de proteína tirosina cinase.
BRPI0817685A2 (pt) Polissacarídeos com funcionalidade azetidínio e seus usos
CR10799A (es) Derivados de metastina y sus usos
ATE523175T1 (de) Ophthalmischer injektor
BRPI0821244A2 (pt) Proteína de cereal hipoalergênica e seus usos
BRPI0719345A2 (pt) Di-hidroimidazóis substituídos e seu uso no tratamento de tumores.
BRPI0819519A2 (pt) Análogos de triarilmetano e seus usos no tratamento de cânceres.
BRPI0913640A2 (pt) substâncias policrômicas e seus usos
FR2915199B1 (fr) Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
BRPI0719708A2 (pt) Novos moduladores de proteína quinase e seus usos terapêuticos.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]