BRPI0709743A2 - tiazolil-diidro-indazol - Google Patents
tiazolil-diidro-indazol Download PDFInfo
- Publication number
- BRPI0709743A2 BRPI0709743A2 BRPI0709743-3A BRPI0709743A BRPI0709743A2 BR PI0709743 A2 BRPI0709743 A2 BR PI0709743A2 BR PI0709743 A BRPI0709743 A BR PI0709743A BR PI0709743 A2 BRPI0709743 A2 BR PI0709743A2
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- alkyl
- cycloalkyl
- alkenyl
- alkynyl
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- -1 thiazolyl dihydro-indazole Chemical compound 0.000 title claims description 142
- 239000000203 mixture Substances 0.000 claims abstract description 65
- 239000002253 acid Substances 0.000 claims abstract description 48
- 150000003839 salts Chemical class 0.000 claims abstract description 41
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 26
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 19
- 150000004677 hydrates Chemical class 0.000 claims abstract description 14
- 239000012453 solvate Substances 0.000 claims abstract description 14
- 150000001875 compounds Chemical class 0.000 claims description 158
- 125000000217 alkyl group Chemical group 0.000 claims description 88
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 44
- 239000013543 active substance Substances 0.000 claims description 39
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 35
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 27
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
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- 229910052794 bromium Inorganic materials 0.000 claims description 14
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
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Classifications
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
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| PCT/EP2007/052916 WO2007115933A1 (de) | 2006-04-06 | 2007-03-27 | Thiazolyl-dihydro-indazole |
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| AU2007227681A1 (en) | 2006-03-15 | 2007-09-27 | Wyeth | N-substituted-azacyclylamines as histamine-3 antagonists |
| US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| US7691868B2 (en) * | 2006-04-06 | 2010-04-06 | Boehringer Ingelheim International Gmbh | Thiazolyl-dihydro-quinazoline |
| US20070259855A1 (en) * | 2006-04-06 | 2007-11-08 | Udo Maier | Thiazolyl-dihydro-indazole |
| PE20080371A1 (es) | 2006-05-19 | 2008-04-09 | Wyeth Corp | N-benzoil-y-n-bencilpirrolidin-3-ilaminas como antagonistas de histamina-3 |
| PE20081152A1 (es) | 2006-10-06 | 2008-08-10 | Wyeth Corp | Azaciclilaminas n-sustituidas como antagonistas de histamina-3 |
| US20080293771A1 (en) * | 2007-05-24 | 2008-11-27 | Wyeth | Azacyclylbenzamide derivatives as histamine-3 antagonists |
| CA2693138A1 (en) | 2007-07-16 | 2009-01-22 | Wyeth Llc | Aminoalkylazole derivatives as histamine-3 antagonists |
| PE20091617A1 (es) * | 2008-03-13 | 2009-11-12 | Boehringer Ingelheim Int | Tiazolil-dihidro-indazoles |
| US20110230472A1 (en) * | 2008-08-29 | 2011-09-22 | Shionogi & Co., Ltd. | Ring-fused azole derivative having pi3k-inhibiting activity |
| EP2421872B1 (en) * | 2009-04-22 | 2015-06-10 | Boehringer Ingelheim International GmbH | Thia-triaza-as-indacenes as pi3-kinases inhibitors for the treatment of cancer |
| EP2845592A1 (en) * | 2009-09-28 | 2015-03-11 | F. Hoffmann-La Roche AG | Benzoxazepin PI3K inhibitor compounds and methods of use |
| ES2646489T3 (es) | 2013-03-15 | 2017-12-14 | Idorsia Pharmaceuticals Ltd | Novedosos derivados de acrilamida como agentes contra la malaria |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
| WO2022092141A1 (ja) * | 2020-10-28 | 2022-05-05 | 塩野義製薬株式会社 | 抗ウイルス活性を有するアミド誘導体 |
| JP7454729B2 (ja) * | 2022-04-27 | 2024-03-22 | 塩野義製薬株式会社 | 抗ウイルス活性を有するアミド誘導体を含有する医薬組成物 |
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| US5547975A (en) * | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US7091227B2 (en) * | 2000-02-07 | 2006-08-15 | Abbott Gmbh & Co. Kg | Benzothiazole derivatives |
| DE10344223A1 (de) * | 2003-09-24 | 2005-04-21 | Merck Patent Gmbh | 1,3-Benzoxazolylderivate als Kinase-Inhibitoren |
| AU2005293607A1 (en) * | 2004-10-07 | 2006-04-20 | Boehringer Ingelheim International Gmbh | PI3 kinases |
| UY29149A1 (es) * | 2004-10-07 | 2006-05-31 | Boehringer Ingelheim Int | Tiazolil-dihidro-indazoles |
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- 2007-03-27 BR BRPI0709743-3A patent/BRPI0709743A2/pt not_active IP Right Cessation
- 2007-03-27 EP EP07727389A patent/EP2018387A1/de not_active Withdrawn
- 2007-03-27 KR KR1020087027299A patent/KR20090026129A/ko not_active Withdrawn
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- 2007-03-27 RU RU2008143557/04A patent/RU2008143557A/ru not_active Application Discontinuation
- 2007-03-27 AU AU2007236047A patent/AU2007236047A1/en not_active Abandoned
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- 2007-03-27 JP JP2009503536A patent/JP2009532417A/ja active Pending
- 2007-03-27 WO PCT/EP2007/052916 patent/WO2007115933A1/de not_active Ceased
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- 2007-04-03 AR ARP070101384A patent/AR060266A1/es unknown
- 2007-04-04 TW TW096111948A patent/TW200806680A/zh unknown
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- 2008-11-25 US US12/277,543 patent/US20090093474A1/en not_active Abandoned
Also Published As
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|---|---|
| KR20090026129A (ko) | 2009-03-11 |
| JP2009532417A (ja) | 2009-09-10 |
| WO2007115933A1 (de) | 2007-10-18 |
| AR060266A1 (es) | 2008-06-04 |
| RU2008143557A (ru) | 2010-06-20 |
| IL194496A0 (en) | 2009-08-03 |
| MX2008012539A (es) | 2008-10-10 |
| AU2007236047A1 (en) | 2007-10-18 |
| US20090093474A1 (en) | 2009-04-09 |
| CN101466717A (zh) | 2009-06-24 |
| CA2647295A1 (en) | 2007-10-18 |
| TW200806680A (en) | 2008-02-01 |
| US20070238718A1 (en) | 2007-10-11 |
| EP2018387A1 (de) | 2009-01-28 |
| ZA200807821B (en) | 2009-08-26 |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |