BRPI0609248A2 - polipeptìdeos de aciltransferase isopenicilina-n alterados e polinucleotìdeos relacionados - Google Patents

polipeptìdeos de aciltransferase isopenicilina-n alterados e polinucleotìdeos relacionados Download PDF

Info

Publication number
BRPI0609248A2
BRPI0609248A2 BRPI0609248-9A BRPI0609248A BRPI0609248A2 BR PI0609248 A2 BRPI0609248 A2 BR PI0609248A2 BR PI0609248 A BRPI0609248 A BR PI0609248A BR PI0609248 A2 BRPI0609248 A2 BR PI0609248A2
Authority
BR
Brazil
Prior art keywords
seq
acid sequence
amino acid
polypeptide
isolated polypeptide
Prior art date
Application number
BRPI0609248-9A
Other languages
English (en)
Portuguese (pt)
Inventor
Roelof Ary Lans Bovenberg
Anke Krebber
Anthony Cox
La Ching Charlene To
Matthew Tobin
Stephane J Jenne
Yong Hong Chen
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI0609248A2 publication Critical patent/BRPI0609248A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01164Isopenicillin-N N-acyltransferase (2.3.1.164)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0609248-9A 2005-02-24 2006-02-24 polipeptìdeos de aciltransferase isopenicilina-n alterados e polinucleotìdeos relacionados BRPI0609248A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05101423 2005-02-24
EP05101423.1 2005-02-24
PCT/EP2006/060256 WO2006089946A2 (fr) 2005-02-24 2006-02-24 Polypeptides d'acyltransferase modifies et polynucleotides associes

Publications (1)

Publication Number Publication Date
BRPI0609248A2 true BRPI0609248A2 (pt) 2010-03-09

Family

ID=34938811

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609248-9A BRPI0609248A2 (pt) 2005-02-24 2006-02-24 polipeptìdeos de aciltransferase isopenicilina-n alterados e polinucleotìdeos relacionados

Country Status (5)

Country Link
EP (1) EP1851309A2 (fr)
KR (1) KR20070107715A (fr)
CN (1) CN101142312A (fr)
BR (1) BRPI0609248A2 (fr)
WO (1) WO2006089946A2 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208845B (en) * 1988-04-08 1994-01-28 Biochemie Gmbh Process for producing penicillin acyle-transferase its coding dna sequence vector containing it and host cell transformated thereby
FI104984B (fi) * 1988-08-11 2000-05-15 Dsm Nv Menetelmä biosynteettisten tai säätelygeenien identifioimiseksi ja käyttämiseksi sekundääristen metaboliittien tuoton parantamiseksi

Also Published As

Publication number Publication date
WO2006089946A2 (fr) 2006-08-31
EP1851309A2 (fr) 2007-11-07
KR20070107715A (ko) 2007-11-07
CN101142312A (zh) 2008-03-12
WO2006089946A3 (fr) 2007-06-21

Similar Documents

Publication Publication Date Title
KR100648480B1 (ko) 세팔로스포린의 개선된 생체내 생산
IL210795A (en) Pyripropene and a biosynthetic gene
AU5248698A (en) Mutant penicillin g acylases
KR101985911B1 (ko) Achromobacter sp. CCM 4824 유래 페니실린 G 아실라제 변이체 및 이의 이용
EP1799817B1 (fr) Expandases mutantes
EP2392649A2 (fr) Adipoyl-7-ADCA produisant des souches
JP3764166B2 (ja) 二次代謝産物を産生するための方法
BRPI0609248A2 (pt) polipeptìdeos de aciltransferase isopenicilina-n alterados e polinucleotìdeos relacionados
EP2084270B1 (fr) Production de betalactamines
US9404139B2 (en) Mutated cephalosporin hydroxylase and its application in deacetylcephalosporanic acid synthesis
WO2008107782A2 (fr) Hydroxylase modifiée et ses applications
EP2809777B1 (fr) Protéines de type mbth dans la production d'antibiotiques semi-synthetique
Marcos et al. Characterization of the reverse transsulfuration gene mecB of Acremonium chrysogenum, which encodes a functional cystathionine-γ-lyase
EP4361251A1 (fr) Micro-organisme produisant de la déacétoxycéphalosporine c pour la production de 7-adca à haute concentration et haute pureté et procédé de production l'utilisant
WO2007006593A2 (fr) Expandases mutantes
EP1675946A1 (fr) Methode de production de penicilline
KR102166288B1 (ko) D-글루타메이트 영양요구성 대장균 및 이를 이용한 목적 물질 생산 방법
US6916641B2 (en) (R)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
RU2300566C2 (ru) РЕКОМБИНАНТНАЯ ПЛАЗМИДА pSVH0106, ОБЕСПЕЧИВАЮЩАЯ СИНТЕЗ Gl7ACA-АЦИЛАЗЫ В КЛЕТКАХ Escherichia coli, И РЕКОМБИНАНТНЫЙ ШТАММ Escherichia coli BL21(DE3)/pSVH0106-ПРОДУЦЕНТ Gl7ACA-АЦИЛАЗЫ
CN117947137A (zh) 用于合成头孢克洛的青霉素酰胺酶
CN116497010A (zh) G-7-adca合成酶及其在制备头孢烷酸类化合物中的应用
CN116590269A (zh) 耐中性环境的海因酶突变体及其应用
Kovacevic et al. Genetic Manipulation of the ß-lactam Antibiotic Biosynthetic Pathway Paul L. Skatrud, JoAnn Hoskins, John S. Wood, Matthew B. Tobin, James R. Miller
WO2006089951A1 (fr) Acyltransferases modifiees servant a preparer differents antibiotiques a base de lactame

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.