BRPI0606790C8 - anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, composição, vetor de expressão, microrganismo transgênico, célula hospedeira procariótica, kit, e, uso de um anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, ou de uma composição - Google Patents

anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, composição, vetor de expressão, microrganismo transgênico, célula hospedeira procariótica, kit, e, uso de um anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, ou de uma composição

Info

Publication number
BRPI0606790C8
BRPI0606790C8 BRPI0606790A BRPI0606790A BRPI0606790C8 BR PI0606790 C8 BRPI0606790 C8 BR PI0606790C8 BR PI0606790 A BRPI0606790 A BR PI0606790A BR PI0606790 A BRPI0606790 A BR PI0606790A BR PI0606790 C8 BRPI0606790 C8 BR PI0606790C8
Authority
BR
Brazil
Prior art keywords
antigen binding
composition
binding portion
human monoclonal
monoclonal antibody
Prior art date
Application number
BRPI0606790A
Other languages
English (en)
Inventor
Rupprecht Charles
Ambrosino Donna
J Barcock Gregory
Mandell Robert
Schonhoff Susan
D Thomas William Jr
Original Assignee
Ct Disease Contr & Prevention
Univ Massachusetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Disease Contr & Prevention, Univ Massachusetts filed Critical Ct Disease Contr & Prevention
Publication of BRPI0606790A2 publication Critical patent/BRPI0606790A2/pt
Publication of BRPI0606790B1 publication Critical patent/BRPI0606790B1/pt
Publication of BRPI0606790C1 publication Critical patent/BRPI0606790C1/pt
Publication of BRPI0606790C8 publication Critical patent/BRPI0606790C8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/205—Rhabdoviridae, e.g. rabies virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

anticorpo humano isolado ou porção de ligação de antígeno do mesmo, polipeptídeo isolado, composição, ácido nucleico isolado, vetor de expressão, célula hospedeira, vacina contra a raiva, kit, uso de um anticorpo monoclonal humano isolado ou porção de ligação de antigeno do mesmo, ou de uma quantidade eficaz de uma composição, metodo para identificar um anticorpo ou fragmento do mesmo, anticorpo ou fragmento do mesmo, e, glicoproteina. os anticorpos monoclonais humanos que especificamente se ligam ao vírus da raiva, porções de ligação de antígeno dos mesmos, e métodos de fabricar e usar tais anticorpos e porções de ligação de antígeno dos mesmos para tratar o vírus da raiva em um paciente, são aqui fomecidos.
BRPI0606790A 2005-02-02 2006-02-02 anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, composição, vetor de expressão, microrganismo transgênico, célula hospedeira procariótica, kit, e, uso de um anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, ou de uma composição BRPI0606790C8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64951205P 2005-02-02 2005-02-02
PCT/US2006/003644 WO2006084006A1 (en) 2005-02-02 2006-02-02 Human antibodies against rabies and uses thereof

Publications (4)

Publication Number Publication Date
BRPI0606790A2 BRPI0606790A2 (pt) 2009-07-14
BRPI0606790B1 BRPI0606790B1 (pt) 2018-10-09
BRPI0606790C1 BRPI0606790C1 (pt) 2019-08-06
BRPI0606790C8 true BRPI0606790C8 (pt) 2021-05-25

Family

ID=36589118

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606790A BRPI0606790C8 (pt) 2005-02-02 2006-02-02 anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, composição, vetor de expressão, microrganismo transgênico, célula hospedeira procariótica, kit, e, uso de um anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, ou de uma composição

Country Status (17)

Country Link
US (4) US7727532B2 (pt)
EP (1) EP1851315B1 (pt)
CN (2) CN101133158B (pt)
BR (1) BRPI0606790C8 (pt)
CA (1) CA2596697C (pt)
DK (1) DK1851315T3 (pt)
ES (1) ES2453973T3 (pt)
HK (1) HK1104060A1 (pt)
HR (1) HRP20140271T1 (pt)
ME (1) ME01785B (pt)
MX (1) MX2007009273A (pt)
PL (1) PL1851315T3 (pt)
PT (1) PT1851315E (pt)
RS (1) RS53239B (pt)
SI (1) SI1851315T1 (pt)
WO (1) WO2006084006A1 (pt)
ZA (1) ZA200707339B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481043B2 (en) * 2001-06-22 2013-07-09 Cpex Pharmaceuticals, Inc. Nasal immunization
BRPI0606790C8 (pt) * 2005-02-02 2021-05-25 Ct Disease Contr & Prevention anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, composição, vetor de expressão, microrganismo transgênico, célula hospedeira procariótica, kit, e, uso de um anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, ou de uma composição
US20110076279A1 (en) * 2006-10-20 2011-03-31 Schering Corporation Fully human anti-vegf antibodies and methods of using
CN101235086B (zh) * 2007-02-02 2011-06-15 吉林圣元科技有限责任公司 重组人抗狂犬病毒抗体
US20110118446A1 (en) * 2007-09-28 2011-05-19 The General Hospital Corporation Methods and compositions for antibody production
CN101812131B (zh) * 2010-05-06 2012-07-04 中国疾病预防控制中心病毒病预防控制所 人源抗狂犬病毒糖蛋白中和性抗体(RVFab8)
CN101812130B (zh) * 2010-05-06 2012-07-04 中国疾病预防控制中心病毒病预防控制所 人源抗狂犬病毒糖蛋白中和性抗体(RVFab5)
WO2012054502A1 (en) * 2010-10-19 2012-04-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Identification of antibodies specific for lyssaviruses and methods of their use
DK2683406T3 (da) 2011-03-11 2019-07-08 Beth Israel Deaconess Medical Ct Inc Anti-cd40-antistoffer og anvendelser deraf
CN103998059B (zh) * 2011-09-30 2016-01-20 赛特瑞恩股份有限公司 用于中和狂犬病病毒的结合分子
CN103374069B (zh) * 2012-04-24 2015-06-03 中国科学院上海生命科学研究院 一种抗狂犬病毒的结合分子2e1
CN103374070B (zh) * 2012-04-24 2016-01-27 中国科学院上海生命科学研究院 一种抗狂犬病毒的结合分子2f5
CN110195072A (zh) * 2013-08-21 2019-09-03 库瑞瓦格股份公司 狂犬病疫苗
CN103954777A (zh) * 2014-05-20 2014-07-30 北京凯思百奥科技发展有限公司 一种狂犬病病毒单克隆抗体及其应用
DK3220947T3 (da) 2014-11-18 2020-11-30 Humabs Biomed S A Antistoffer som potent neutraliserer rabiesvirus og øvrige lyssavirusser og anvendelser deraf
CN104722449A (zh) * 2015-04-09 2015-06-24 京东方科技集团股份有限公司 胶涂布头、涂胶设备及触控显示面板的制备方法
US10722571B2 (en) * 2015-06-10 2020-07-28 Celltrion Inc. Rabies virus G protein epitope, and rabies virus neutralising binding molecule that binds specifically thereto
US10450367B2 (en) * 2015-08-13 2019-10-22 University Of Massachusetts Human antibodies against rabies and uses thereof
JP6976931B2 (ja) 2015-09-04 2021-12-08 プリマトープ・セラピューティクス・インコーポレイテッド ヒト化抗ｃｄ４０抗体及びその使用
ZA201604024B (en) * 2015-09-26 2017-08-30 Serum Institute Of India Pvt Ltd Improved feeding strategies and purification processes for monoclonal antibody production
RU2661028C2 (ru) * 2016-11-11 2018-07-11 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф.Гамалеи" Министерства здравоохранения Российской Федедерации Фармацевтическая композиция для пассивной иммунизации против бешенства, фармацевтический набор, способ применения фармацевтического набора
MY197200A (en) * 2016-12-23 2023-05-31 Serum Institute Of India Pvt Ltd Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof
CN108359640B (zh) * 2018-01-31 2020-12-01 武汉枢密脑科学技术有限公司 一种标记全脑区神经网络结构的狂犬病毒、其制备和应用
WO2019227039A1 (en) * 2018-05-24 2019-11-28 Lankenau Institute For Medical Research Compositions comprising antibodies to rabies virus and the uses thereof
CN111171145B (zh) * 2020-01-21 2021-11-05 兰州生物制品研究所有限责任公司 一种抗狂犬病病毒单克隆抗体、制备方法及用途
EP4203994A4 (en) * 2020-08-28 2024-07-03 Torigen Pharmaceuticals Inc PREPARATIONS WITH IMPROVED IMMUNE MEMORY AND USES THEREOF

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7847094A (en) * 1993-09-30 1995-04-18 Thomas Jefferson University Oral vaccination of mammals
US5840300A (en) * 1995-09-11 1998-11-24 Trustees Of The University Of Pennsylvania Methods and compositions comprising single chain recombinant antibodies
US20040013672A1 (en) * 2000-05-16 2004-01-22 Thomas Jefferson University Recombinant antibodies, and compositions and methods for making and using the same
EP1282703B1 (en) * 2000-05-16 2008-10-15 Thomas Jefferson University Rabies virus-specific neutralizing human monoclonal antibodies and nucleic acids and related methods
US7115717B2 (en) * 2001-05-18 2006-10-03 Kirin Beer Kabushiki Kaisha Anti-TRAIL-R antibodies
CA2537371A1 (en) * 2003-09-04 2005-03-17 Crucell Holland B.V. Antigenic peptides of rabies virus and uses thereof
BRPI0606790C8 (pt) * 2005-02-02 2021-05-25 Ct Disease Contr & Prevention anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, composição, vetor de expressão, microrganismo transgênico, célula hospedeira procariótica, kit, e, uso de um anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, ou de uma composição

Also Published As

Publication number Publication date
US20110008360A1 (en) 2011-01-13
EP1851315B1 (en) 2013-12-25
US20090041777A1 (en) 2009-02-12
PT1851315E (pt) 2014-03-25
ME01785B (me) 2014-09-20
BRPI0606790C1 (pt) 2019-08-06
EP1851315A1 (en) 2007-11-07
US8226952B2 (en) 2012-07-24
WO2006084006A1 (en) 2006-08-10
CA2596697C (en) 2019-04-09
CN101133158B (zh) 2012-12-05
US20150315266A1 (en) 2015-11-05
RS53239B (en) 2014-08-29
BRPI0606790A2 (pt) 2009-07-14
ZA200707339B (en) 2014-04-30
DK1851315T3 (en) 2014-03-24
CN101133158A (zh) 2008-02-27
CA2596697A1 (en) 2006-08-10
US20130039926A1 (en) 2013-02-14
HRP20140271T1 (hr) 2014-05-23
HK1104060A1 (en) 2008-01-04
BRPI0606790B1 (pt) 2018-10-09
SI1851315T1 (sl) 2014-06-30
MX2007009273A (es) 2008-02-19
ES2453973T3 (es) 2014-04-09
US7727532B2 (en) 2010-06-01
PL1851315T3 (pl) 2014-06-30
CN102936284A (zh) 2013-02-20

Similar Documents

Publication Publication Date Title
BRPI0606790C1 (pt) anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, composição, vetor de expressão, microrganismo transgênico, célula hospedeira procariótica, kit, e, uso de um anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, ou de uma composição
BRPI0507433B8 (pt) anticorpo monoclonal recombinante ou sua parte de ligação ao antígeno, composição, ácido nucleico isolado, vetor de expressão, e, kit
BRPI0612273C1 (pt) anticorpo de ligação a il-1 beta ou fragmento de ligação a il-1 beta do mesmo, ácido nucleico, vetor, e, composição
RS52790B (en) MONOCLONAL ANTIBODIES AGAINST CLAUDINE-18 FOR THE CANCER TREATMENT
BR112013004579A2 (pt) proteína de ligação à mmp9, ácido nucleico, vetor, célula, composição farmacêutica e seu uso bem como método de detecção da expressão mmp9
BR112022015374A2 (pt) Anticorpos contra sars-cov-2 e métodos de uso dos mesmos
MX2010002269A (es) Composiciones y metodos que comprenden proteinas de union para adalimumab.
BRPI0816117B8 (pt) anticorpo monoclonal isolado ou fragmento do mesmo, composiçãofarmacêutica, kit para tratamento de desordens relacionadas com colesterol, e, uso de uma proteína de ligação de antígeno ou de um anticorpo monoclonal ou fragmento do mesmo
BR112017006203A2 (pt) anticorpos isolado, caninizado e monoclonal ou fragmento de ligação ao antígeno dos mesmos, ácido nucleico isolado, vetor de expressão, célula hospedeira, peptídeo antigênico isolado, proteína de fusão, composição farmacêutica, e, método de aumento da atividade de uma célula imune.
BR112022020706A2 (pt) Anticorpos contra sars-cov-2 e métodos de uso dos mesmos
EA200970477A1 (ru) Человеческие моноклональные антитела к btla и способы применения
PT2305715T (pt) Anticorpo monoclonal para a proteína de ligação a osteoprotegerina
BR112022022503A2 (pt) Anticorpos neutralizantes que se ligam à proteína s de sars-cov-2
BRPI0418766A (pt) anticorpos e moléculas derivadas destes que se ligam às proteìnas steap-1
NO20085131L (no) Lyofiliserte preparater av anti-EGFR-antistoffer
DE602005027399D1 (de) Für humane matriptase spezifische bindungsproteine
MY150400A (en) Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof
UA93855C2 (ru) Вакцина, способствует росту, базирующейся ha нейтрализующем эпитопе
NO20075103L (no) Antistoffer og relaterte molekyler som bindes til 161P2F10B proteiner
BRPI0808940A8 (pt) anticorpo humano ou fragmento de ligação do mesmo, antígeno, polinucleotídeo, vetor, célula hospedeira, método para preparar um anticorpo ou um fragmento de ligação ou cadeia(s) de imunoglobulina do mesmo, anticorpo, cadeia de imunoglobulina ou um fragmento de ligação do mesmo, composição, usos do anticorpo ou fragmento de ligação, de um antígeno, de um polinucleotídeo, de um vetor, ou de uma célula, e de uma molécula de ligação a antígeno tumoral, método para clonagem molecular de um anticorpo, e, kit para o diagnóstico de um tumor
BR112012012911A2 (pt) métodos para triar uma molécula capaz de ligação a cd4, para produzir uma composição terapêutica, para triar um anticorpo ou fragmento de anticorpo, in vitro para a ativação de células t regulatórias cd4+cd25+, para tratar um indivíduo, e para triar a presença de células regulatórias t cd4+cd25+ em uma amostra, composição terapêutica, anticorpo ou fragmento de anticorpo, peptídeo isolado, mimótopo de um peptídeo isolado, ácido nucleico, vetor, célula hospedeira ou hibridoma, usos de um anticorpo ou fragmento de anticorpo, do peptídeo isolado e de uma célula t regulatória cd4+cd25+, célula t regulatória cd4+cd25+, e, kit.
MX2023006773A (es) Composiciones de agentes de union a antigenos de guanilato ciclasa c (gcc) y metodos de uso de estos.
BR112021016791A2 (pt) Proteínas de ligação de antígenos que se ligam a bcma
ZA202201464B (en) Anti-tigit antibodies and application thereof
MX2021009975A (es) Anticuerpos de cd33 y métodos para usar los mismos para tratar el cáncer.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/10/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/10/2018, OBSERVADAS AS CONDICOES LEGAIS. (CO) REFERENTE A RPI 2492 DE 09/10/2018, QUANTO AO NOME DE UM DOS INVENTORES.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/10/2018, OBSERVADAS AS CONDICOES LEGAIS. (CO) REFERENTE A RPI 2533 DE 23/07/2019, QUANTO AO ITEM (73) NOME DO TITULAR.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/02/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF