BRPI0606761A2 - pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização - Google Patents

pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização

Info

Publication number
BRPI0606761A2
BRPI0606761A2 BRPI0606761-1A BRPI0606761A BRPI0606761A2 BR PI0606761 A2 BRPI0606761 A2 BR PI0606761A2 BR PI0606761 A BRPI0606761 A BR PI0606761A BR PI0606761 A2 BRPI0606761 A2 BR PI0606761A2
Authority
BR
Brazil
Prior art keywords
compositions containing
imidazoles
production process
substituted pyrroles
substituted
Prior art date
Application number
BRPI0606761-1A
Other languages
English (en)
Inventor
Baptiste Ronan
Frank Halley
Catherine Souaille
Fabrice Viviani
Youssef El-Ahmad
Eric Bacque
Michel Tabart
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BRPI0606761A2 publication Critical patent/BRPI0606761A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PIRRóIS E IMIDAZóIS SUBSTITUìDOS, COMPOSIçõES QUE OS CONTêM, PROCESSO DE PRODUçãO E UTILIZAçãO. A presente invenção refere-se a pirróis e imidazóis substituidos, composições que os contêm, processo de produção e utilização. A presente invenção refere-se notadamente ao preparo de pirróis e imidazóis substituidos, às composições que os contêm, ao respectivo processo de preparo, e à respectiva utilização como medicamento, em particular como agentes anticancerosos.
BRPI0606761-1A 2005-02-03 2006-02-01 pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização BRPI0606761A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0501092A FR2881426B1 (fr) 2005-02-03 2005-02-03 Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation
PCT/FR2006/000220 WO2006082309A1 (fr) 2005-02-03 2006-02-01 l-H-PYROLE-2-CARBOXAMIDES ET IMIDAZOLE-5-CARBOXAMIDES ET LEUR UTILISATION EN TANT MODULATEURS DES KINASES FAK, KDR ET TIE2 POUR TRAITER LE CANCER

Publications (1)

Publication Number Publication Date
BRPI0606761A2 true BRPI0606761A2 (pt) 2009-07-14

Family

ID=34954950

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606761-1A BRPI0606761A2 (pt) 2005-02-03 2006-02-01 pirróis e imidazóis substituìdos, composições que os contêm, processo de produção e utilização

Country Status (20)

Country Link
US (1) US7560571B2 (pt)
EP (1) EP1856043B1 (pt)
JP (1) JP2008528661A (pt)
KR (1) KR20070103420A (pt)
CN (1) CN101133023A (pt)
AR (1) AR053540A1 (pt)
AT (1) ATE512133T1 (pt)
AU (1) AU2006210343A1 (pt)
BR (1) BRPI0606761A2 (pt)
CA (1) CA2595987A1 (pt)
EA (1) EA012267B1 (pt)
FR (1) FR2881426B1 (pt)
IL (1) IL184710A0 (pt)
MA (1) MA29264B1 (pt)
MX (1) MX2007009442A (pt)
NO (1) NO20074414L (pt)
TW (1) TW200640857A (pt)
UY (1) UY29361A1 (pt)
WO (1) WO2006082309A1 (pt)
ZA (1) ZA200706338B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2881742B1 (fr) 2005-02-10 2007-09-07 Aventis Pharma Sa Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation
EP2007732B1 (en) 2006-04-11 2011-11-23 Vertex Pharmaceuticals, Inc. Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases
EP2307456B1 (en) 2008-06-27 2014-10-15 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
JP5688366B2 (ja) 2008-08-15 2015-03-25 エヌサーティー・ファーマシューティカルズ・インコーポレーテッド 治療薬剤としての、ｓ−ニトロソグルタチオンレダクターゼの新規ピロール阻害剤
JP5524209B2 (ja) 2008-08-15 2014-06-18 エヌサーティー・ファーマシューティカルズ・インコーポレーテッド Ｓ−ニトロソグルタチオンレダクターゼのピロール阻害剤
US8673961B2 (en) 2008-08-15 2014-03-18 N30 Pharmaceuticals, Inc. Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents
CN102775354A (zh) * 2011-05-10 2012-11-14 无锡立诺康医药科技有限公司 一种合成4-芳基-5-羧酸咪唑及其酯的工艺方法
GEP201706748B (en) 2012-08-10 2017-10-10 Boehringer Ingelheim Int Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
JP6486954B2 (ja) 2014-01-29 2019-03-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としてのピラゾール化合物
SI3390390T1 (sl) 2015-12-16 2021-12-31 Boehringer Ingelheim International Gmbh Bipirazolilni derivati, uporabni za zdravljenje avtoimunskih bolezni
WO2017123695A1 (en) 2016-01-13 2017-07-20 Boehringer Ingelheim International Gmbh Isoquinolones as btk inhibitors
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020173507A1 (en) * 2000-08-15 2002-11-21 Vincent Santora Urea compounds and methods of uses
GB0107901D0 (en) 2001-03-29 2001-05-23 Cyclacel Ltd Anti-cancer compounds
US7307097B2 (en) * 2001-09-27 2007-12-11 Smithkline Beechman Corporation Chemical compounds
US20040138269A1 (en) * 2002-10-11 2004-07-15 Sugen, Inc. Substituted pyrroles as kinase inhibitors
BRPI0409952A (pt) * 2003-04-30 2006-04-25 Pfizer Prod Inc agentes anti-diabéticos
DE10354060A1 (de) * 2003-11-19 2005-06-02 Merck Patent Gmbh Pyrrolderivate
US7183285B2 (en) 2004-04-29 2007-02-27 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
FR2881742B1 (fr) 2005-02-10 2007-09-07 Aventis Pharma Sa Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation

Also Published As

Publication number Publication date
FR2881426B1 (fr) 2007-03-30
WO2006082309A1 (fr) 2006-08-10
AU2006210343A1 (en) 2006-08-10
EP1856043A1 (fr) 2007-11-21
UY29361A1 (es) 2006-08-31
KR20070103420A (ko) 2007-10-23
US20080045542A1 (en) 2008-02-21
TW200640857A (en) 2006-12-01
IL184710A0 (en) 2007-12-03
AR053540A1 (es) 2007-05-09
FR2881426A1 (fr) 2006-08-04
JP2008528661A (ja) 2008-07-31
NO20074414L (no) 2007-11-05
CA2595987A1 (fr) 2006-08-10
US7560571B2 (en) 2009-07-14
CN101133023A (zh) 2008-02-27
EA012267B1 (ru) 2009-08-28
ATE512133T1 (de) 2011-06-15
EP1856043B1 (fr) 2011-06-08
MA29264B1 (fr) 2008-02-01
MX2007009442A (es) 2008-03-10
ZA200706338B (en) 2008-11-26
EA200701648A1 (ru) 2008-02-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.