BRPI0606409A2 - matrizes suplementadas para o reparo de fraturas ósseas - Google Patents
matrizes suplementadas para o reparo de fraturas ósseasInfo
- Publication number
- BRPI0606409A2 BRPI0606409A2 BRPI0606409-4A BRPI0606409A BRPI0606409A2 BR PI0606409 A2 BRPI0606409 A2 BR PI0606409A2 BR PI0606409 A BRPI0606409 A BR PI0606409A BR PI0606409 A2 BRPI0606409 A2 BR PI0606409A2
- Authority
- BR
- Brazil
- Prior art keywords
- pth
- matrices
- incorporated
- matrix
- bone fractures
- Prior art date
Links
- 208000010392 Bone Fractures Diseases 0.000 title abstract 4
- 239000011159 matrix material Substances 0.000 abstract 3
- 239000008187 granular material Substances 0.000 abstract 2
- 230000035876 healing Effects 0.000 abstract 2
- 238000013270 controlled release Methods 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Composite Materials (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Materials Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
MATRIZES SUPLEMENTADAS PARA O REPARO DE FRATURAS óSSEAS. A presente invenção refere-se a matrizes suplementadas compreendendo um PTH incorporado de maneira liberável aqui, opcionalmente contendo um material granular. O PTH é incorporado ou através de ligação covalente à matriz ou através de interação não-covalente com a matriz e/ou os grânulos. Essas matrizes suplementadas diminuem o tempo de cura em comparação com auto-enxerto ou disparam a cura de fraturas ósseas as quais, de outra forma, poderiam não se curar. As matrizes são biocompativeis e biodegradáveis e podem ser formadas in vitro ou in vivo, no momento da implantação. O PTH pode ser uma parte de um peptídeo de fusão. PTH pode ser incorporado nas matrizes com retenção completa de sua bioatividade. PTH pode ser incorporado de maneira liberável, usando técnicas que fornecem o controle sobre como e quando e em que grau o PTH é liberado usando a matriz como um veículo de liberação controlado para curar fraturas ósseas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64171505P | 2005-01-06 | 2005-01-06 | |
US64264405P | 2005-01-10 | 2005-01-10 | |
PCT/EP2006/050069 WO2006072622A2 (en) | 2005-01-06 | 2006-01-06 | Supplemented matrices for the repair of bone fractures |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0606409A2 true BRPI0606409A2 (pt) | 2009-06-23 |
Family
ID=36581768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0606409-4A BRPI0606409A2 (pt) | 2005-01-06 | 2006-01-06 | matrizes suplementadas para o reparo de fraturas ósseas |
Country Status (12)
Country | Link |
---|---|
US (1) | US20060148704A1 (pt) |
EP (3) | EP2316497A3 (pt) |
JP (2) | JP5328153B2 (pt) |
KR (1) | KR20070108170A (pt) |
AU (1) | AU2006204461C1 (pt) |
BR (1) | BRPI0606409A2 (pt) |
CA (1) | CA2592973A1 (pt) |
ES (2) | ES2593051T3 (pt) |
MX (1) | MX2007008319A (pt) |
RU (1) | RU2422172C2 (pt) |
SG (1) | SG161218A1 (pt) |
WO (1) | WO2006072622A2 (pt) |
Families Citing this family (22)
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US8852240B2 (en) | 2004-10-25 | 2014-10-07 | Kieran Murphy, Llc | Methods and compositions for fostering and preserving bone growth |
US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
EP2029184B1 (en) | 2006-05-26 | 2011-02-23 | Baxter International Inc. | Injectable fibrin composition for bone augmentation |
KR101421750B1 (ko) | 2006-05-26 | 2014-07-22 | 박스터 헬쓰케어 에스에이 | 주입가능한 골 결함 충전제 |
US9066994B2 (en) | 2006-08-31 | 2015-06-30 | Warsaw Orthopedic, Inc. | Demineralized cancellous strip DBM graft |
US8388626B2 (en) * | 2006-11-08 | 2013-03-05 | Warsaw Orthopedic, Inc. | Methods of employing calcium phosphate cement compositions and osteoinductive proteins to effect vertebrae interbody fusion absent an interbody device |
HUE060822T2 (hu) * | 2006-12-29 | 2023-04-28 | Ossifi Mab Llc | Módszerek a csontnövekedés megváltoztatására SOST vagy WISE antagonista vagy agonista adásával |
ES2381448T3 (es) | 2007-03-26 | 2012-05-28 | Baxter International Inc. | Material de relleno de huecos inyectable par el aumento de tejidos blandos |
JP5907656B2 (ja) * | 2007-04-23 | 2016-04-26 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | ストロンチウム化合物を含むフィブリン組成物 |
CN101663043B (zh) * | 2007-04-27 | 2014-03-12 | 尤尼基因实验室公司 | 促进和保持骨生长的方法和组合物 |
WO2008157608A1 (en) * | 2007-06-18 | 2008-12-24 | Cartlix, Inc. | Composite scaffolds for tissue regeneration |
WO2009047361A2 (en) * | 2007-10-12 | 2009-04-16 | Kuros Biosurgery Ag | Injectable fibrin compositions for tissue augmentation comprising strontium salt |
CA2710798A1 (en) * | 2007-12-28 | 2009-07-09 | Kuros Biosurgery Ag | Pdgf fusion proteins incorporated into fibrin foams |
MX2010011440A (es) | 2008-04-18 | 2010-12-21 | Kuros Biosurgery Ag | Un dispositivo de suministro, un kit que contiene el dispositivo, y metodo para operar el dispositivo. |
WO2011031476A2 (en) * | 2009-08-25 | 2011-03-17 | Emory University | Compositions and methods for treatment or prevention of post-operative organ or tissue inflammation |
KR101114773B1 (ko) * | 2009-10-23 | 2012-03-05 | 세원셀론텍(주) | 연골조직 수복용 조성물의 제조방법 |
WO2012123028A1 (en) | 2011-03-16 | 2012-09-20 | Kuros Biosurgery Ag | Pharmaceutical formulation for use in spinal fusion |
US8404256B2 (en) * | 2011-05-06 | 2013-03-26 | The University Of Memphis Research Foundation | Biomaterial composite composition and method of use |
RU2563992C2 (ru) * | 2013-08-12 | 2015-09-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Композитные матриксы на основе фиброина шелка, желатина и гидроксиапатита для регенерации костной ткани |
EP3536353A1 (en) * | 2018-03-09 | 2019-09-11 | Kuros Biosurgery AG | Method and kits for producing a fibrin matrix |
RU2702520C1 (ru) * | 2019-04-17 | 2019-10-08 | Анна Владимировна Алабут | Способ эндопротезирования коленного сустава у пациентов с остеопорозом |
RU2764373C1 (ru) * | 2021-03-29 | 2022-01-17 | Федеральное государственное бюджетное военное образовательное учреждение высшего образования "Военно-медицинская академия имени С.М. Кирова" Министерства обороны Российской Федерации (ВМедА) | Способ применения ген-активированного материала при несращениях длинных костей |
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-
2006
- 2006-01-06 ES ES06707674.5T patent/ES2593051T3/es active Active
- 2006-01-06 MX MX2007008319A patent/MX2007008319A/es active IP Right Grant
- 2006-01-06 EP EP10181752.6A patent/EP2316497A3/en not_active Withdrawn
- 2006-01-06 KR KR1020077018079A patent/KR20070108170A/ko not_active Application Discontinuation
- 2006-01-06 EP EP06707674.5A patent/EP1833522B1/en active Active
- 2006-01-06 US US11/327,214 patent/US20060148704A1/en not_active Abandoned
- 2006-01-06 ES ES16175576T patent/ES2902872T3/es active Active
- 2006-01-06 RU RU2007129844/15A patent/RU2422172C2/ru not_active IP Right Cessation
- 2006-01-06 JP JP2007549892A patent/JP5328153B2/ja not_active Expired - Fee Related
- 2006-01-06 CA CA002592973A patent/CA2592973A1/en not_active Abandoned
- 2006-01-06 AU AU2006204461A patent/AU2006204461C1/en not_active Ceased
- 2006-01-06 WO PCT/EP2006/050069 patent/WO2006072622A2/en active Application Filing
- 2006-01-06 BR BRPI0606409-4A patent/BRPI0606409A2/pt active Search and Examination
- 2006-01-06 SG SG201002289-5A patent/SG161218A1/en unknown
- 2006-01-06 EP EP16175576.4A patent/EP3111966B1/en active Active
-
2013
- 2013-04-22 JP JP2013089407A patent/JP2013173770A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ES2902872T3 (es) | 2022-03-30 |
EP2316497A3 (en) | 2014-05-07 |
EP3111966A1 (en) | 2017-01-04 |
JP2013173770A (ja) | 2013-09-05 |
AU2006204461C1 (en) | 2012-01-12 |
KR20070108170A (ko) | 2007-11-08 |
RU2422172C2 (ru) | 2011-06-27 |
ES2593051T3 (es) | 2016-12-05 |
AU2006204461A1 (en) | 2006-07-13 |
WO2006072622A3 (en) | 2006-11-23 |
RU2007129844A (ru) | 2009-02-20 |
EP1833522A2 (en) | 2007-09-19 |
WO2006072622A2 (en) | 2006-07-13 |
EP3111966B1 (en) | 2021-10-13 |
CA2592973A1 (en) | 2006-07-13 |
EP2316497A2 (en) | 2011-05-04 |
EP1833522B1 (en) | 2016-06-22 |
US20060148704A1 (en) | 2006-07-06 |
MX2007008319A (es) | 2007-10-04 |
AU2006204461B2 (en) | 2011-07-07 |
SG161218A1 (en) | 2010-05-27 |
JP5328153B2 (ja) | 2013-10-30 |
JP2008526810A (ja) | 2008-07-24 |
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