AR057073A1 - Composicion biocompatible para la sustitucion/regeneracion de tejidos - Google Patents

Composicion biocompatible para la sustitucion/regeneracion de tejidos

Info

Publication number
AR057073A1
AR057073A1 ARP060102636A ARP060102636A AR057073A1 AR 057073 A1 AR057073 A1 AR 057073A1 AR P060102636 A ARP060102636 A AR P060102636A AR P060102636 A ARP060102636 A AR P060102636A AR 057073 A1 AR057073 A1 AR 057073A1
Authority
AR
Argentina
Prior art keywords
crosslinking
biocompatible composition
natural polymers
regeneration
replacement
Prior art date
Application number
ARP060102636A
Other languages
English (en)
Inventor
Giuseppe Calvosa
Original Assignee
Giuseppe Calvosa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giuseppe Calvosa filed Critical Giuseppe Calvosa
Publication of AR057073A1 publication Critical patent/AR057073A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente composicion biocompatible para la sustitucion/regeneracion de tejidos articulares, en particular del nucleo pulposo, pero también de tejidos no articulares como el tejido oseo del esqueleto, provee una matriz hidrogética que comprende un primero y un segundo polímero natural, células aptas para regenerar el tejido del nucleo de disco, un agente reticulante apto para efectuar la reticulacion de por lo menos uno de dichos polímeros naturales in situ, a fin de conferir así a la composicion biocompatible una adecuada resistencia a las cargas y moléculas aptas para estimular el crecimiento y/o la diferenciacion celular, en la cual uno de los dos polímeros naturales es alginato de sodio. En una realizacion particular, la susodicha composicion presenta una densidad inicial anterior a la reticulacion que la hace inyectable. En particular, la accion sobre el alginato de sodio es ejercida por un agente reticulante contenido en partículas poliméricas biodegradables de liberacion controlada, producidas a partir de polímeros naturales, por ejemplo, gelatina, o a partir de polímeros sintéticos, por ejemplo ácido poliláctico, o copolímero, ácido láctico-ácido glicolico.
ARP060102636A 2005-06-20 2006-06-20 Composicion biocompatible para la sustitucion/regeneracion de tejidos AR057073A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000071A ITPI20050071A1 (it) 2005-06-20 2005-06-20 Composizione biocompatibile per la sostituzione/rigenerazione di tessuti

Publications (1)

Publication Number Publication Date
AR057073A1 true AR057073A1 (es) 2007-11-14

Family

ID=37430811

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102636A AR057073A1 (es) 2005-06-20 2006-06-20 Composicion biocompatible para la sustitucion/regeneracion de tejidos

Country Status (7)

Country Link
US (1) US20090136576A1 (es)
EP (1) EP1901791B1 (es)
CN (1) CN101189035A (es)
AR (1) AR057073A1 (es)
ES (1) ES2393403T3 (es)
IT (1) ITPI20050071A1 (es)
WO (1) WO2006136905A2 (es)

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PT2347775T (pt) 2005-12-13 2020-07-14 The President And Fellows Of Harvard College Estruturas em andaime para transplante celular
CA2711267C (en) 2007-01-03 2018-07-10 California Stem Cell, Inc. Stem cell growth media and methods of making and using same
US9770535B2 (en) 2007-06-21 2017-09-26 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US10328133B2 (en) 2008-02-13 2019-06-25 President And Fellows Of Harvard College Continuous cell programming devices
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
US9012399B2 (en) 2008-05-30 2015-04-21 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
US9297005B2 (en) 2009-04-13 2016-03-29 President And Fellows Of Harvard College Harnessing cell dynamics to engineer materials
US9044335B2 (en) 2009-05-05 2015-06-02 Cornell University Composite tissue-engineered intervertebral disc with self-assembled annular alignment
JP5926180B2 (ja) 2009-07-31 2016-05-25 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 寛容原性療法のための細胞のプログラミングの方法
US9610328B2 (en) 2010-03-05 2017-04-04 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1
AU2011238646B2 (en) * 2010-03-29 2016-02-04 Evonik Corporation Compositions and methods for improved retention of a pharmaceutical composition at a local administration site
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
CN102399378B (zh) * 2010-09-07 2013-11-13 中国人民解放军总医院 一种温度敏感的壳聚糖水凝胶及其制备方法
DK2624873T3 (da) 2010-10-06 2020-03-02 Harvard College Injicerbare, pore-dannende hydrogeler til materiale-baserede celleterapier
WO2012064697A2 (en) 2010-11-08 2012-05-18 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
WO2012148684A1 (en) 2011-04-27 2012-11-01 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
EP2701745B1 (en) 2011-04-28 2018-07-11 President and Fellows of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
EP2714073B1 (en) 2011-06-03 2021-03-10 President and Fellows of Harvard College In situ antigen-generating cancer vaccine
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
LT2838515T (lt) 2012-04-16 2020-03-10 President And Fellows Of Harvard College Mezoporinės silico dioksido kompozicijos, skirtos imuninio atsako moduliavimui
US20160022872A1 (en) * 2013-03-06 2016-01-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Cell-based compositions, cell-based bandage devices and systems and methods of treatment therewith
JP7348708B2 (ja) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
WO2016123573A1 (en) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
CN107708756A (zh) 2015-04-10 2018-02-16 哈佛学院院长等 免疫细胞捕获装置及其制备和使用方法
CN109072197A (zh) 2016-02-06 2018-12-21 哈佛学院校长同事会 重塑造血巢以重建免疫
CA3018152A1 (en) * 2016-03-23 2017-09-28 National University Corporation Hokkaido University Composition comprising a salt of alginic acid for treating intervertebral disc
CA3030427A1 (en) 2016-07-13 2018-01-18 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
KR101885729B1 (ko) * 2016-07-21 2018-08-06 의료법인 성광의료재단 지방조직 유래 중간엽 줄기세포 및 히알루론산 유도체를 포함하는 조성물 및 그를 제조하는 방법
CN106110402A (zh) * 2016-08-31 2016-11-16 朱家源 海藻酸钠水凝胶支架构建的组织工程皮肤及其制备方法
RU2700933C1 (ru) * 2019-05-27 2019-09-24 Артем Иванович Трофименко Гидрогель для регенерации пульпы зуба и периодонта

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Also Published As

Publication number Publication date
ES2393403T3 (es) 2012-12-21
US20090136576A1 (en) 2009-05-28
ITPI20050071A1 (it) 2006-12-21
EP1901791A2 (en) 2008-03-26
WO2006136905A2 (en) 2006-12-28
WO2006136905A3 (en) 2007-05-31
EP1901791B1 (en) 2012-08-15
CN101189035A (zh) 2008-05-28

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