BRPI0604253A - forma deltad-cristalina de cloridrato de ivabradina, um processo para sua preparação e composições farmacêuticas contendo-as - Google Patents

forma deltad-cristalina de cloridrato de ivabradina, um processo para sua preparação e composições farmacêuticas contendo-as

Info

Publication number
BRPI0604253A
BRPI0604253A BRPI0604253-8A BRPI0604253A BRPI0604253A BR PI0604253 A BRPI0604253 A BR PI0604253A BR PI0604253 A BRPI0604253 A BR PI0604253A BR PI0604253 A BRPI0604253 A BR PI0604253A
Authority
BR
Brazil
Prior art keywords
deltad
pharmaceutical compositions
compositions containing
crystalline form
preparation
Prior art date
Application number
BRPI0604253-8A
Other languages
English (en)
Inventor
Stephane Horvath
Marie-Noulle Auguste
Gerard Damien
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36588996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0604253(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0604253A publication Critical patent/BRPI0604253A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

FORMA DELTAd-CRISTALINA DE CLORIDRATO DE IVABRADINA, UM PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO-AS. A presente invenção refere-se a forma o<sym>d-cristalina de cloridrato ivabradina da fórmula (I): caracterizada por seu gráfico de difração de raio X de pó. Medicamentos.
BRPI0604253-8A 2005-10-11 2006-10-10 forma deltad-cristalina de cloridrato de ivabradina, um processo para sua preparação e composições farmacêuticas contendo-as BRPI0604253A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0510354A FR2891827B1 (fr) 2005-10-11 2005-10-11 Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent

Publications (1)

Publication Number Publication Date
BRPI0604253A true BRPI0604253A (pt) 2007-08-21

Family

ID=36588996

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0604253-8A BRPI0604253A (pt) 2005-10-11 2006-10-10 forma deltad-cristalina de cloridrato de ivabradina, um processo para sua preparação e composições farmacêuticas contendo-as

Country Status (32)

Country Link
US (3) US7384932B2 (pt)
EP (2) EP1775287A1 (pt)
JP (1) JP2007112797A (pt)
KR (1) KR20070040310A (pt)
CN (1) CN1948293A (pt)
AP (1) AP2185A (pt)
AR (1) AR056573A1 (pt)
AU (1) AU2006228028B2 (pt)
BR (1) BRPI0604253A (pt)
CA (1) CA2564369C (pt)
CO (1) CO5840253A1 (pt)
CR (1) CR8647A (pt)
EA (1) EA010286B1 (pt)
EC (1) ECSP066914A (pt)
FR (1) FR2891827B1 (pt)
GE (1) GEP20094654B (pt)
GT (1) GT200600448A (pt)
IL (1) IL178545A (pt)
MA (1) MA28625B1 (pt)
MX (1) MXPA06011767A (pt)
MY (1) MY140490A (pt)
NI (1) NI200600240A (pt)
NO (1) NO20064588L (pt)
NZ (1) NZ550436A (pt)
PE (1) PE20070547A1 (pt)
SA (1) SA06270371B1 (pt)
SG (1) SG131857A1 (pt)
TW (1) TW200800221A (pt)
UA (1) UA90266C2 (pt)
UY (1) UY29856A1 (pt)
WO (1) WO2007042657A1 (pt)
ZA (1) ZA200608404B (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP2097383B1 (en) 2006-11-30 2012-02-08 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
CN101353325B (zh) * 2007-07-27 2011-11-09 上海优拓医药科技有限公司 稳定型盐酸伊伐布雷定结晶及其制备方法
US8212026B2 (en) 2007-05-30 2012-07-03 Ind-Swift Laboratories Limited Process for the preparation of ivabradine hydrochloride and polymorph thereof
WO2010072409A1 (en) 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Process for preparation of ivabradine
CN101768117B (zh) * 2008-12-29 2014-05-07 北京德众万全药物技术开发有限公司 一种盐酸伊伐布雷定晶型及其制备方法
CN101774969B (zh) 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
US8270169B2 (en) 2009-03-24 2012-09-18 Raytheon Company Translating hinge
WO2010128525A2 (en) 2009-05-04 2010-11-11 Dinesh Shantilal Patel A formulation of ivabradine for treating the cardiovascular disease
EP2902384B1 (en) 2010-02-12 2017-11-08 KRKA, D.D., Novo Mesto Form of ivabradine hydrochloride
HUP1000245A2 (en) 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
WO2012025940A1 (en) * 2010-08-25 2012-03-01 Cadila Healthcare Limited Polymorphic form of ivabradine hydrochloride and process for preparation thereof
CN102731400A (zh) * 2011-04-11 2012-10-17 山东新时代药业有限公司 一种盐酸伊伐布雷定的新晶型、制备方法及其在制备药物组合物中的用途
EP2726462B1 (en) 2011-08-02 2017-03-22 Sandoz AG Acetone solvate of ivabradine hydrochloride
WO2013064427A1 (en) 2011-11-04 2013-05-10 Synthon Bv A process for making crystalline delta-form of ivabradine hydrochloride
EP2589594A1 (en) 2011-11-04 2013-05-08 Urquima S.A. Ivabradine hydrochloride Form IV
US9120755B2 (en) * 2011-11-14 2015-09-01 Cadila Healthcare Limited Polymorphic forms of ivabradine hydrochloride
CN103012269B (zh) * 2013-01-05 2014-08-13 江苏宇田生物医药科技有限公司 一种盐酸伊伐布雷定晶型c及其制备方法
WO2014114341A1 (en) 2013-01-24 2014-07-31 Synthon Bv Process for making ivabradine
EP2781509B2 (en) 2013-03-19 2023-06-14 Chemo Research, S.L. New polymorph of ivabradine hydrochloride and method for its preparation
CZ305096B6 (cs) * 2013-10-02 2015-04-29 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice
ES2672472T3 (es) 2013-12-12 2018-06-14 Synthon Bv Composición farmacéutica que comprende ivabradina amorfa
EP2774606B1 (en) 2014-02-14 2019-01-30 Synthon B.V. Pharmaceutical composition comprising ivabradine hydrochloride polymorph IV
CN103880748B (zh) * 2014-04-03 2015-09-16 南京正大天晴制药有限公司 一种盐酸伊伐布雷定结构类似物及其制备方法和应用
CZ305436B6 (cs) 2014-07-10 2015-09-16 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice
WO2016102423A1 (en) 2014-12-22 2016-06-30 Ratiopharm Gmbh Composition comprising ivabradine in a dissolved form
CN105503726B (zh) * 2015-12-30 2019-07-30 浙江美诺华药物化学有限公司 伊伐布雷定盐酸盐晶型变体delta-d的制备方法
EP3366282A1 (en) 2017-02-28 2018-08-29 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral pharmaceutical compositions of ivabradine
TR201703066A2 (tr) 2017-02-28 2018-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari
CN107200710A (zh) * 2017-05-22 2017-09-26 苏州华健瑞达医药技术有限公司 盐酸伊伐布雷定新晶型、制备方法及含有其的组合物
IT202000025312A1 (it) * 2020-10-26 2022-04-26 Cambrex Profarmaco Milano S R L Processi per la preparazione di polimorfi di ivabradina hcl

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9017453D0 (en) 1990-08-09 1990-09-26 Mcivor Robert C Fluid additive regulating apparatus
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
EP1958937A1 (fr) 2008-08-20
IL178545A (en) 2017-04-30
MY140490A (en) 2009-12-31
GEP20094654B (en) 2009-03-25
IL178545A0 (en) 2007-02-11
EA010286B1 (ru) 2008-08-29
SA06270371B1 (ar) 2010-03-08
CA2564369C (fr) 2010-06-15
US20080227771A1 (en) 2008-09-18
ECSP066914A (es) 2007-05-30
NO20064588L (no) 2007-04-12
EA200601661A1 (ru) 2007-04-27
WO2007042657A1 (fr) 2007-04-19
TW200800221A (en) 2008-01-01
CO5840253A1 (es) 2007-12-31
JP2007112797A (ja) 2007-05-10
CN1948293A (zh) 2007-04-18
SG131857A1 (en) 2007-05-28
US20070082886A1 (en) 2007-04-12
AR056573A1 (es) 2007-10-10
PE20070547A1 (es) 2007-07-07
MXPA06011767A (es) 2007-04-10
ZA200608404B (en) 2008-06-25
CA2564369A1 (fr) 2007-04-11
NZ550436A (en) 2007-12-21
US7384932B2 (en) 2008-06-10
FR2891827B1 (fr) 2007-12-28
AU2006228028A1 (en) 2007-04-26
FR2891827A1 (fr) 2007-04-13
US20090318418A1 (en) 2009-12-24
CR8647A (es) 2007-06-08
UA90266C2 (ru) 2010-04-26
GT200600448A (es) 2007-05-21
EP1775287A1 (fr) 2007-04-18
MA28625B1 (fr) 2007-06-01
US7879841B2 (en) 2011-02-01
AP2185A (en) 2010-12-30
KR20070040310A (ko) 2007-04-16
AU2006228028B2 (en) 2011-08-25
UY29856A1 (es) 2006-11-30
AP2006003757A0 (en) 2006-10-31
NI200600240A (es) 2008-01-10

Similar Documents

Publication Publication Date Title
BRPI0604253A (pt) forma deltad-cristalina de cloridrato de ivabradina, um processo para sua preparação e composições farmacêuticas contendo-as
BRPI0600795A (pt) forma betad-cristalina de cloridrato de ivabradina, um processo para preparação do mesmo e composições farmacêuticas contendo o mesmo
BRPI0604250A (pt) forma cristalina delta de cloridrato de ivabradina, processo para sua preparação e composições farmacêuticas contendo a mesma
BRPI0600796B8 (pt) forma gama-cristalina de cloridrato de ivabradina, processo para preparação do mesmo e composições farmacêuticas contendo o mesmo
BRPI0600696A (pt) forma gamad-cristalina de cloridrato de ivabradina, processo para preparação do mesmo e composições farmacêuticas contendo o mesmo
BRPI0600623A (pt) forma beta-cristalina de cloridrato de ivabradina, processo para preparação do mesmo e composições farmacêuticas contendo o mesmo
BRPI0603043A (pt) forma cristalina iv de agomelatina, um processo para sua preparação e composições farmacêuticas contendo-a
BRPI0603074A (pt) forma cristalina iii de agomelatina, um processo para sua preparação e composições farmacêuticas contendo-a
BRPI0603059A (pt) forma cristalina v de agomelatina, um processo para sua preparação e composições farmacêuticas contendo-a
BRPI0804994A2 (pt) forma cristalina vi de agomelatina, um processo para a sua preparação e composições farmacêuticas contendo-a
BRPI0502228A (pt) forma cristalina alfa de ranelato de estrÈncio, processo para sua preparação, e composições farmacêuticas que a contêm
UY29855A1 (es) Forma cristalina delta de clorhidrato de ivabradina, su procedimiento de preparación y composiciones farmacéuticas que la contienen
CU20060195A7 (es) Forma cristalina delta-d del clorhidrato de la ivabradina, su procedimiento de preparación, y las composiciones farmacéuticas que lo contienen
CU20060193A7 (es) Procedimiento de preparación de la forma cristalina delta del clorhidrato de la ivabradina y las composiciones farmacéuticas que lo contienen

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL