BRPI0518571A2 - peptÍdeos de alfa timosina como adjuvantes de vacina contra cÂncer - Google Patents
peptÍdeos de alfa timosina como adjuvantes de vacina contra cÂncerInfo
- Publication number
- BRPI0518571A2 BRPI0518571A2 BRPI0518571-8A BRPI0518571A BRPI0518571A2 BR PI0518571 A2 BRPI0518571 A2 BR PI0518571A2 BR PI0518571 A BRPI0518571 A BR PI0518571A BR PI0518571 A2 BRPI0518571 A2 BR PI0518571A2
- Authority
- BR
- Brazil
- Prior art keywords
- alpha
- cancer vaccine
- peptides
- thymosine
- subject
- Prior art date
Links
- 229940022399 cancer vaccine Drugs 0.000 title abstract 5
- 238000009566 cancer vaccine Methods 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 239000012646 vaccine adjuvant Substances 0.000 title abstract 2
- 108010046075 Thymosin Proteins 0.000 abstract 2
- 230000000899 immune system response Effects 0.000 abstract 2
- 102000007501 Thymosin Human genes 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/49—Breast
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63317504P | 2004-12-06 | 2004-12-06 | |
| PCT/US2005/043985 WO2006062917A2 (en) | 2004-12-06 | 2005-12-06 | Alpha thymosin peptides as cancer vaccine adjuvants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518571A2 true BRPI0518571A2 (pt) | 2008-11-25 |
Family
ID=36578462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518571-8A BRPI0518571A2 (pt) | 2004-12-06 | 2005-12-06 | peptÍdeos de alfa timosina como adjuvantes de vacina contra cÂncer |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100092499A1 (https=) |
| EP (1) | EP1835931A4 (https=) |
| JP (1) | JP2008523067A (https=) |
| KR (1) | KR20070086663A (https=) |
| CN (1) | CN101072582B (https=) |
| AU (1) | AU2005314271B2 (https=) |
| BR (1) | BRPI0518571A2 (https=) |
| CA (1) | CA2588685A1 (https=) |
| EA (1) | EA015510B1 (https=) |
| IL (1) | IL183264A (https=) |
| MX (1) | MX2007006717A (https=) |
| NO (1) | NO20072705L (https=) |
| NZ (1) | NZ555571A (https=) |
| UA (1) | UA90493C2 (https=) |
| WO (1) | WO2006062917A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100317583A1 (en) * | 2007-12-14 | 2010-12-16 | Sciclone Pharmaceuticals, Inc. | Treatment of melanoma with alpha thymosin peptides in combination with an antineoplastic heat shock apoptosis activator (hsaa) |
| EP2427213B1 (en) | 2009-05-08 | 2015-04-01 | Sciclone Pharmaceuticals, Inc. | Alpha thymosin peptides as vaccine enhancers |
| WO2012109106A1 (en) * | 2011-02-09 | 2012-08-16 | Sciclone Pharmaceuticals, Inc. | Thymosin alpha peptide for preventing, reducing the severity of, and treating infection |
| JP6385280B2 (ja) * | 2012-01-20 | 2018-09-05 | トーメ クロイツ、フェルナンド | 自家癌細胞ワクチン |
| JP2015510887A (ja) * | 2012-03-08 | 2015-04-13 | サイクローン・ファーマシューティカルズ・インコーポレイテッドＳｃｉＣｌｏｎｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 化膿性鼻副鼻腔炎の処置のためのチモシンαの使用 |
| EP3943101A1 (en) * | 2014-10-21 | 2022-01-26 | SciClone Pharmaceuticals International Ltd. | Treatment of cancer with immune stimulator alpha thymosin peptide |
| CN107281476B (zh) * | 2017-04-06 | 2020-11-24 | 中国医科大学 | 一种抗原肽RL-佐剂CpGODN7909偶联物及其制备方法和应用 |
| RU2645957C1 (ru) * | 2017-04-10 | 2018-02-28 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения лучевых повреждений мочевого пузыря |
| RU2663468C1 (ru) * | 2017-09-25 | 2018-08-06 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения местно-распространенного нерезектабельного рака поджелудочной железы |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US653758A (en) * | 1900-03-20 | 1900-07-17 | Austin Gale | Hay-stacking device. |
| DE2604845A1 (de) | 1976-02-07 | 1977-08-18 | Knoll Ag | Neue piperazinderivate |
| JPH0420624A (ja) * | 1990-02-06 | 1992-01-24 | Kanji Yokoe | 勾配側溝施工法及び当該工法に使用する可変側溝 |
| US6537585B1 (en) * | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| MXPA02000192A (es) * | 1999-06-30 | 2004-08-12 | Corixa Corp | Composiciones y metodos para la terapia y diagnostico de cancer de pulmon. |
| ES2299626T3 (es) * | 2001-10-26 | 2008-06-01 | Rhode Island Hospital | Aumento de timosina para asegurar una inmunizacion genetica. |
| AU2002342151B2 (en) * | 2001-10-26 | 2007-07-19 | Immuno-Rx, Inc. | Immunotherapy for reversing immune suppression |
| JP2005537246A (ja) | 2002-06-28 | 2005-12-08 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | サイマルファシンを用いて腫瘍抗原発現をアップレギュレートする方法 |
| EA008037B1 (ru) * | 2003-03-28 | 2007-02-27 | Сциклон Фармасьютикалс, Инк. | ЛЕЧЕНИЕ ИНФЕКЦИЙ, ВЫЗЫВАЕМЫХ ГРИБАМИ p. ASPERGILLUS, С ПОМОЩЬЮ ТИМОЗИНА АЛЬФА 1 |
| EP2633866A3 (en) * | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Combination therapy |
| EP2427213B1 (en) * | 2009-05-08 | 2015-04-01 | Sciclone Pharmaceuticals, Inc. | Alpha thymosin peptides as vaccine enhancers |
-
2005
- 2005-12-06 EP EP05853022A patent/EP1835931A4/en not_active Withdrawn
- 2005-12-06 CA CA002588685A patent/CA2588685A1/en not_active Abandoned
- 2005-12-06 US US11/720,909 patent/US20100092499A1/en not_active Abandoned
- 2005-12-06 KR KR1020077014527A patent/KR20070086663A/ko not_active Ceased
- 2005-12-06 NZ NZ555571A patent/NZ555571A/en not_active IP Right Cessation
- 2005-12-06 EA EA200701166A patent/EA015510B1/ru not_active IP Right Cessation
- 2005-12-06 JP JP2007545547A patent/JP2008523067A/ja active Pending
- 2005-12-06 BR BRPI0518571-8A patent/BRPI0518571A2/pt not_active IP Right Cessation
- 2005-12-06 CN CN2005800417998A patent/CN101072582B/zh not_active Expired - Lifetime
- 2005-12-06 WO PCT/US2005/043985 patent/WO2006062917A2/en not_active Ceased
- 2005-12-06 UA UAA200707406A patent/UA90493C2/ru unknown
- 2005-12-06 MX MX2007006717A patent/MX2007006717A/es active IP Right Grant
- 2005-12-06 AU AU2005314271A patent/AU2005314271B2/en not_active Ceased
-
2007
- 2007-05-16 IL IL183264A patent/IL183264A/en not_active IP Right Cessation
- 2007-05-29 NO NO20072705A patent/NO20072705L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2588685A1 (en) | 2006-06-15 |
| EP1835931A4 (en) | 2008-12-17 |
| AU2005314271B2 (en) | 2011-06-16 |
| MX2007006717A (es) | 2007-08-06 |
| NZ555571A (en) | 2009-02-28 |
| EA200701166A1 (ru) | 2008-02-28 |
| JP2008523067A (ja) | 2008-07-03 |
| EP1835931A2 (en) | 2007-09-26 |
| AU2005314271A1 (en) | 2006-06-15 |
| KR20070086663A (ko) | 2007-08-27 |
| CN101072582A (zh) | 2007-11-14 |
| IL183264A (en) | 2010-12-30 |
| IL183264A0 (en) | 2007-09-20 |
| WO2006062917A2 (en) | 2006-06-15 |
| US20100092499A1 (en) | 2010-04-15 |
| NO20072705L (no) | 2007-09-05 |
| UA90493C2 (ru) | 2010-05-11 |
| CN101072582B (zh) | 2012-06-27 |
| EA015510B1 (ru) | 2011-08-30 |
| WO2006062917A3 (en) | 2006-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: BASEADO NO ARTIGO 216 1O DA LPI, PARA QUE A PETICAO NO 20080118249/RJ DE 09/09/2008 SEJA ACEITA, APRESENTE COPIA AUTENTICADA DA PROCURACAO. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 8A, 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |