WO2008098212A3 - Extended release formulations of glucagon and other peptides and proteins - Google Patents

Extended release formulations of glucagon and other peptides and proteins

Info

Publication number
WO2008098212A3
WO2008098212A3 PCT/US2008/053488 US2008053488W WO2008098212A3 WO 2008098212 A3 WO2008098212 A3 WO 2008098212A3 US 2008053488 W US2008053488 W US 2008053488W WO 2008098212 A3 WO2008098212 A3 WO 2008098212A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
glucagon
release
preparation
pharmaceutical
circulation
Prior art date
Application number
PCT/US2008/053488
Other languages
French (fr)
Other versions
WO2008098212A2 (en )
Inventor
Timothy Andrew Stewart
Solomon Tse
Gregory A Sacha
Michael J Akers
Original Assignee
Diobex Inc
Timothy Andrew Stewart
Solomon Tse
Gregory A Sacha
Michael J Akers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Abstract

A pharmaceutical preparation comprising a suspension of glucagon in the presence of a metallic cation and optionally an excipient provides for a sustained release of glucagon into the circulation of a treated patient following injection of pharmaceutical preparation.
PCT/US2008/053488 2007-02-08 2008-02-08 Extended release formulations of glucagon and other peptides and proteins WO2008098212A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US90050907 true 2007-02-08 2007-02-08
US60/900,509 2007-02-08

Publications (2)

Publication Number Publication Date
WO2008098212A2 true WO2008098212A2 (en) 2008-08-14
WO2008098212A3 true true WO2008098212A3 (en) 2008-10-16

Family

ID=39682449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/053488 WO2008098212A3 (en) 2007-02-08 2008-02-08 Extended release formulations of glucagon and other peptides and proteins

Country Status (1)

Country Link
WO (1) WO2008098212A3 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012460A1 (en) 2010-07-19 2012-01-26 Xeris Pharmaceuticals, Inc. Stable glucagon formulations for the treatment of hypoglycemia
US8697644B2 (en) 2011-03-10 2014-04-15 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of peptide drugs
JP6117811B2 (en) 2011-10-31 2017-04-19 ゼリス ファーマシューティカルズ インコーポレイテッド Formulations for the treatment of diabetes
WO2013086292A1 (en) * 2011-12-09 2013-06-13 Enject, Inc. Glucagon formulations
US9125805B2 (en) 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
CN104902919A (en) 2012-12-21 2015-09-09 赛诺菲 Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists
US9018162B2 (en) 2013-02-06 2015-04-28 Xeris Pharmaceuticals, Inc. Methods for rapidly treating severe hypoglycemia
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
EP3080150A1 (en) 2013-12-13 2016-10-19 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086729A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/gip receptor agonists
WO2015155140A1 (en) 2014-04-07 2015-10-15 Sanofi Dual glp-1 / glucagon receptor agonists derived from exendin-4
EP3129395A1 (en) 2014-04-07 2017-02-15 Sanofi Exendin-4 derivatives as peptidic dual glp-1 / glucagon receptor agonists
RU2016141925A (en) 2014-04-07 2018-05-08 Санофи Dual peptide agonists of glp-1 / glucagon derived from exendin-4
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
WO2016201248A1 (en) * 2015-06-10 2016-12-15 Xeris Pharmaceuticals, Inc. Use of low dose glucagon
US9982029B2 (en) 2015-07-10 2018-05-29 Sanofi Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284727B1 (en) * 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
US20060014670A1 (en) * 2002-12-27 2006-01-19 Green Daniel T Compositions and methods for the prevention and control of insulin-induced hypoglycemia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284727B1 (en) * 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
US20060014670A1 (en) * 2002-12-27 2006-01-19 Green Daniel T Compositions and methods for the prevention and control of insulin-induced hypoglycemia

Also Published As

Publication number Publication date Type
WO2008098212A2 (en) 2008-08-14 application

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