WO2008098212A3 - Extended release formulations of glucagon and other peptides and proteins - Google Patents

Extended release formulations of glucagon and other peptides and proteins

Info

Publication number
WO2008098212A3
WO2008098212A3 PCT/US2008/053488 US2008053488W WO2008098212A3 WO 2008098212 A3 WO2008098212 A3 WO 2008098212A3 US 2008053488 W US2008053488 W US 2008053488W WO 2008098212 A3 WO2008098212 A3 WO 2008098212A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
glucagon
peptides
proteins
extended release
release formulations
Prior art date
Application number
PCT/US2008/053488
Other languages
French (fr)
Other versions
WO2008098212A2 (en )
Inventor
Timothy Andrew Stewart
Solomon Tse
Gregory A Sacha
Michael J Akers
Original Assignee
Diobex Inc
Timothy Andrew Stewart
Solomon Tse
Gregory A Sacha
Michael J Akers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Abstract

A pharmaceutical preparation comprising a suspension of glucagon in the presence of a metallic cation and optionally an excipient provides for a sustained release of glucagon into the circulation of a treated patient following injection of pharmaceutical preparation.
PCT/US2008/053488 2007-02-08 2008-02-08 Extended release formulations of glucagon and other peptides and proteins WO2008098212A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US90050907 true 2007-02-08 2007-02-08
US60/900,509 2007-02-08

Publications (2)

Publication Number Publication Date
WO2008098212A2 true WO2008098212A2 (en) 2008-08-14
WO2008098212A3 true true WO2008098212A3 (en) 2008-10-16

Family

ID=39682449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/053488 WO2008098212A3 (en) 2007-02-08 2008-02-08 Extended release formulations of glucagon and other peptides and proteins

Country Status (1)

Country Link
WO (1) WO2008098212A3 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012460A1 (en) 2010-07-19 2012-01-26 Xeris Pharmaceuticals, Inc. Stable glucagon formulations for the treatment of hypoglycemia
US8697644B2 (en) 2011-03-10 2014-04-15 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of peptide drugs
JP6117811B2 (en) 2011-10-31 2017-04-19 ゼリス ファーマシューティカルズ インコーポレイテッド Formulations for the treatment of diabetes
WO2013086292A1 (en) * 2011-12-09 2013-06-13 Enject, Inc. Glucagon formulations
US9125805B2 (en) 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
CN104902919A (en) 2012-12-21 2015-09-09 赛诺菲 Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists
US9018162B2 (en) 2013-02-06 2015-04-28 Xeris Pharmaceuticals, Inc. Methods for rapidly treating severe hypoglycemia
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
EP3080150B1 (en) 2013-12-13 2018-08-01 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086729A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/gip receptor agonists
WO2015155140A1 (en) 2014-04-07 2015-10-15 Sanofi Dual glp-1 / glucagon receptor agonists derived from exendin-4
EP3129395A1 (en) 2014-04-07 2017-02-15 Sanofi Exendin-4 derivatives as peptidic dual glp-1 / glucagon receptor agonists
RU2016141925A (en) 2014-04-07 2018-05-08 Санофи Dual peptide agonists of glp-1 / glucagon derived from exendin-4
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
WO2016201248A1 (en) * 2015-06-10 2016-12-15 Xeris Pharmaceuticals, Inc. Use of low dose glucagon
US9982029B2 (en) 2015-07-10 2018-05-29 Sanofi Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284727B1 (en) * 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
US20060014670A1 (en) * 2002-12-27 2006-01-19 Green Daniel T Compositions and methods for the prevention and control of insulin-induced hypoglycemia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284727B1 (en) * 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
US20060014670A1 (en) * 2002-12-27 2006-01-19 Green Daniel T Compositions and methods for the prevention and control of insulin-induced hypoglycemia

Also Published As

Publication number Publication date Type
WO2008098212A2 (en) 2008-08-14 application

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