BRPI0518218A - formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions - Google Patents

formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions

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Publication number
BRPI0518218A
BRPI0518218A BRPI0518218-2A BRPI0518218A BRPI0518218A BR PI0518218 A BRPI0518218 A BR PI0518218A BR PI0518218 A BRPI0518218 A BR PI0518218A BR PI0518218 A BRPI0518218 A BR PI0518218A
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BR
Brazil
Prior art keywords
conditions
diseases
teeth
prevention
treatment
Prior art date
Application number
BRPI0518218-2A
Other languages
Portuguese (pt)
Inventor
Qi Jia
Yuan Zhao
Original Assignee
Unigen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unigen Pharmaceuticals Inc filed Critical Unigen Pharmaceuticals Inc
Publication of BRPI0518218A publication Critical patent/BRPI0518218A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

FORMULAçãO DE INIBIDORES DUAIS DE SISTEMA DE EICOSANOIDE E SISTEMA DE CITOCINA PARA USO NA PREVENçãO E TRATAMENTO DE DOENçAS E CONDIçõES ORAIS. A presente invenção refere-se a uma nova composição de matéria compreendida de uma mistura de duas classes específicas - flavonóídes de anel B livre e flavanas - para uso na prevenção e tratamento de doenças e condições associadas à boca, gengivas e dentes Essa composição de matéria inibe símultaneamente a atividade enzimática da cíclooxigenase (COX) e da lípoxígenase (LOX) e reduz a produção de cítocína no nível de mRNA em células e tecidos periodontais normais, envelhecidos e lesionados. Essa invenção proporciona ainda um método para a prevenção e tratamento de doenças e condições da boca, gengivas e dentes, O método para prevenir e tratar doenças e condições da boca, dentes e gengivas compreende a administração a um paciente que necessite desta de uma quantidade terapeutícamente eficaz de uma composição que compreende uma mistura de flavonóídes de anel B livre e flavanas sintetizados e/ou isolados uma planta simples ou de múltiplas plantas, preferivelmente plantas do gênero Scutellar,a, Oroxylum, Acacia ou Uncuaria e veículos farmacêutica e/ou cosmetícamente aceitos. Finalmente, a presente invenção proporciona um método para a prevenção e o tratamento de doenças e condições da boca, dentes ou gengivas, incluindo, mas sem limitação, doenças periodontaís, tais como gengívite, periodontíte, pulpíte, condições periodontaís provocadas pelo implante físico de dentaduras, trauma, lesões, bruxismo, neoplasia ou outros processos degenerativos; matéria alba, peliculas, placas dentais, cálculos e manchas. O uso da composição descrita aqui também produz o beneficio de manter a produção ótima de saliva e pH, minimizar o crescimento bacteríano, reduzir a formação de películas e placa, inibir a descalcíficação dos dentes e cáries dentárias, promover a remíneralízação que produz gengivas saudáveis, branquear os dentes, manter a higiene oral e reduzir o odor desagradável oral (halitose).FORMULATION OF TWO INHIBITORS OF THE EICOSANOID SYSTEM AND CYTOKINE SYSTEM FOR USE IN PREVENTION AND TREATMENT OF ORAL DISEASES AND CONDITIONS. The present invention relates to a novel composition of matter comprised of a mixture of two specific classes - free B ring flavonoids and flavanas - for use in the prevention and treatment of diseases and conditions associated with the mouth, gums and teeth. it simultaneously inhibits the enzymatic activity of cyclooxygenase (COX) and lipoxygenase (LOX) and reduces cytokine production at the level of mRNA in normal, aged and injured periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums comprises administering to a patient in need thereof a therapeutically amount. An effective composition of a composition comprising a mixture of free B-ring flavonoids and synthesized and / or isolated single-plant and multi-plant flavans, preferably plants of the genus Scutellar, a, Oroxylum, Acacia or Uncuaria and pharmaceutically and / or cosmetically acceptable carriers. . Finally, the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including, but not limited to, periodontal diseases such as gingivitis, periodontitis, pulpitis, periodontal conditions caused by the physical implantation of dentures. , trauma, injuries, bruxism, neoplasia or other degenerative processes; alba matter, films, dental plaques, calculi and stains. Use of the composition described herein also has the benefit of maintaining optimal saliva and pH production, minimizing bacterial growth, reducing film and plaque formation, inhibiting decalcification of teeth and dental caries, promoting remineralisation that produces healthy gums, Whiten teeth, maintain oral hygiene and reduce unpleasant oral odor (halitosis).

BRPI0518218-2A 2004-10-19 2005-10-19 formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions BRPI0518218A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62016304P 2004-10-19 2004-10-19
PCT/US2005/037936 WO2006045056A2 (en) 2004-10-19 2005-10-19 Flavonoid composition for treating oral diseases

Publications (1)

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BRPI0518218A true BRPI0518218A (en) 2008-11-04

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EP (1) EP1804787A4 (en)
JP (1) JP2008517069A (en)
KR (1) KR20070073921A (en)
CN (1) CN101083981B (en)
AU (1) AU2005295190A1 (en)
BR (1) BRPI0518218A (en)
CA (1) CA2584124A1 (en)
MX (1) MX2007004471A (en)
NZ (1) NZ554517A (en)
RU (1) RU2007118535A (en)
TW (1) TW200630102A (en)
WO (1) WO2006045056A2 (en)

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