WO2006045056A3 - Flavonoid composition for treating oral diseases - Google Patents

Flavonoid composition for treating oral diseases Download PDF

Info

Publication number
WO2006045056A3
WO2006045056A3 PCT/US2005/037936 US2005037936W WO2006045056A3 WO 2006045056 A3 WO2006045056 A3 WO 2006045056A3 US 2005037936 W US2005037936 W US 2005037936W WO 2006045056 A3 WO2006045056 A3 WO 2006045056A3
Authority
WO
WIPO (PCT)
Prior art keywords
gums
diseases
teeth
conditions
mouth
Prior art date
Application number
PCT/US2005/037936
Other languages
French (fr)
Other versions
WO2006045056A2 (en
Inventor
Qi Jia
Yuan Zhao
Original Assignee
Unigen Pharamaceuticals Inc
Qi Jia
Yuan Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unigen Pharamaceuticals Inc, Qi Jia, Yuan Zhao filed Critical Unigen Pharamaceuticals Inc
Priority to MX2007004471A priority Critical patent/MX2007004471A/en
Priority to EP05810437A priority patent/EP1804787A4/en
Priority to NZ554517A priority patent/NZ554517A/en
Priority to BRPI0518218-2A priority patent/BRPI0518218A/en
Priority to CA002584124A priority patent/CA2584124A1/en
Priority to CN2005800436448A priority patent/CN101083981B/en
Priority to AU2005295190A priority patent/AU2005295190A1/en
Priority to JP2007538073A priority patent/JP2008517069A/en
Publication of WO2006045056A2 publication Critical patent/WO2006045056A2/en
Publication of WO2006045056A3 publication Critical patent/WO2006045056A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-Ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity and reduces cytokine production at the mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria, Oroxylum, Acacia or Uncaria genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including but not limited to periodontal diseases, such as gingivitis, periodontitis, pulpitis, periodontal conditions caused by the physical implantation of oral dentures, trauma, injuries, bruxism, neoplastic and other degenerative processes; material alba, pellicles, dental plagues, calculus, and stains. Use of the composition described herein also affords the benefit of maintaining optimum saliva production and pH, minimizing bacterial growth, reducing the formation of pellicles and plague, inhibiting tooth decalcification and tooth caries (decay), promoting remineralization, which yields healthy gums, whitening teeth, maintaining healthy oral hygiene and reducing oral malodour (halitosis).
PCT/US2005/037936 2004-10-19 2005-10-19 Flavonoid composition for treating oral diseases WO2006045056A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MX2007004471A MX2007004471A (en) 2004-10-19 2005-10-19 Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions.
EP05810437A EP1804787A4 (en) 2004-10-19 2005-10-19 Flavonoid composition for treating oral diseases
NZ554517A NZ554517A (en) 2004-10-19 2005-10-19 Flavonoid composition for treating oral diseases
BRPI0518218-2A BRPI0518218A (en) 2004-10-19 2005-10-19 formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions
CA002584124A CA2584124A1 (en) 2004-10-19 2005-10-19 Flavonoid composition for treating oral diseases
CN2005800436448A CN101083981B (en) 2004-10-19 2005-10-19 Flavonoid composition for treating oral diseases
AU2005295190A AU2005295190A1 (en) 2004-10-19 2005-10-19 Flavonoid composition for treating oral diseases
JP2007538073A JP2008517069A (en) 2004-10-19 2005-10-19 Formulations of dual eicosanoid / cytokine inhibitors for use in the prevention or treatment of oral diseases and conditions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62016304P 2004-10-19 2004-10-19
US60/620,163 2004-10-19

Publications (2)

Publication Number Publication Date
WO2006045056A2 WO2006045056A2 (en) 2006-04-27
WO2006045056A3 true WO2006045056A3 (en) 2007-02-01

Family

ID=36203714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/037936 WO2006045056A2 (en) 2004-10-19 2005-10-19 Flavonoid composition for treating oral diseases

Country Status (12)

Country Link
EP (1) EP1804787A4 (en)
JP (1) JP2008517069A (en)
KR (1) KR20070073921A (en)
CN (1) CN101083981B (en)
AU (1) AU2005295190A1 (en)
BR (1) BRPI0518218A (en)
CA (1) CA2584124A1 (en)
MX (1) MX2007004471A (en)
NZ (1) NZ554517A (en)
RU (1) RU2007118535A (en)
TW (1) TW200630102A (en)
WO (1) WO2006045056A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0409179A (en) 2003-04-04 2006-05-02 Unigen Pharmaceuticals Inc formulation of dual cyclooxygenase (cox) and lipoxygenase (lox) inhibitors for mammalian skin care
CN101141999A (en) * 2004-12-22 2008-03-12 高露洁-棕榄公司 Oral care compositions containing free-b-ring flavonoids andflavans
US20060140881A1 (en) * 2004-12-22 2006-06-29 Guofeng Xu Oral care compositions containing flavonoids and flavans
GB0625430D0 (en) * 2006-12-20 2007-01-31 Mars Uk Ltd Composition
US20080261898A1 (en) * 2007-04-17 2008-10-23 Liao Heather H Composition and method for cancer treatment and prevention
JP2008308460A (en) * 2007-06-15 2008-12-25 Kao Corp Method for purifying low gallate body of non-polymeric catechins
RU2440821C2 (en) * 2007-10-01 2012-01-27 Колгейт-Палмолив Компани Compositions for oral cavity care, containing vegetable extracts
JP5265177B2 (en) * 2007-11-13 2013-08-14 株式会社ｍｉｍｏｚａｘ Composition for improving bowel movements containing acacia bark
JP5563753B2 (en) * 2008-08-29 2014-07-30 サントリーホールディングス株式会社 Glucosyltransferase inhibitor containing epigallocatechin gallate polymer as active ingredient
JP2010136703A (en) * 2008-12-15 2010-06-24 Kao Corp Method for producing non-gallate compound of non-polymer catechins
WO2011052804A1 (en) * 2009-10-30 2011-05-05 Tokyo University Of Science Educational Foundation Administrative Organization Method of delivering agent into target cell
KR101293335B1 (en) * 2011-11-16 2013-08-06 한승국 The liquefied dentifrice making method besides
CN102657781B (en) * 2012-03-22 2013-09-25 韩继双 Spraying agent for treating periodontitis
CN103520012A (en) * 2013-10-18 2014-01-22 柳州两面针股份有限公司 Application of baicalin in preparation of oral care product
CN103520054B (en) * 2013-10-18 2016-07-20 柳州两面针股份有限公司 Ramulus Uncariae Cum Uncis extract application in preparing oral care product
KR102580941B1 (en) * 2016-04-21 2023-09-19 주식회사 엘지생활건강 Composition for prevention or treatment of oral disease comprising Qucercetin 3-glucoside
DE102016207337A1 (en) 2016-04-29 2017-11-02 Henkel Ag & Co. Kgaa Toothpaste for improving gingival adhesion
CN107648111A (en) * 2017-10-30 2018-02-02 刘俊君 A kind of Chinese herbal toothpaste
KR20200041659A (en) 2018-10-12 2020-04-22 주식회사 엘지생활건강 Composition for prevention or treatment of oral disease
JP7448122B2 (en) * 2020-09-10 2024-03-12 株式会社アカシアの樹 Oral flora improvement and maintenance agent, plaque/plaque removal and tartar formation prevention agent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009699A2 (en) * 2000-07-28 2002-02-07 Immupharm Aps Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract
WO2002047615A2 (en) * 2000-12-13 2002-06-20 University Of Rochester Oral compositions and use thereof
US20030216481A1 (en) * 2002-04-30 2003-11-20 Unigen Pharmaceuticals, Inc. Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0662408B2 (en) * 1987-10-01 1994-08-17 太陽化学株式会社 Anti-caries and anti-periodontal composition
US6264926B1 (en) * 1999-02-12 2001-07-24 Council Of Scientific And Industrial Research Formulation useful as a natural herbal tooth powder
US6319523B1 (en) * 2000-06-29 2001-11-20 James H. Zhou Composition and method for inhibiting oral bacteria
JP2003212771A (en) * 2002-01-23 2003-07-30 Taiyo Kagaku Co Ltd Anti-neissria bacterium composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009699A2 (en) * 2000-07-28 2002-02-07 Immupharm Aps Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract
WO2002047615A2 (en) * 2000-12-13 2002-06-20 University Of Rochester Oral compositions and use thereof
US20030216481A1 (en) * 2002-04-30 2003-11-20 Unigen Pharmaceuticals, Inc. Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1804787A2 *

Also Published As

Publication number Publication date
JP2008517069A (en) 2008-05-22
CA2584124A1 (en) 2006-04-27
CN101083981A (en) 2007-12-05
KR20070073921A (en) 2007-07-10
EP1804787A4 (en) 2009-01-14
AU2005295190A1 (en) 2006-04-27
WO2006045056A2 (en) 2006-04-27
EP1804787A2 (en) 2007-07-11
TW200630102A (en) 2006-09-01
CN101083981B (en) 2013-03-27
RU2007118535A (en) 2008-11-27
NZ554517A (en) 2011-02-25
MX2007004471A (en) 2007-06-18
BRPI0518218A (en) 2008-11-04

Similar Documents

Publication Publication Date Title
WO2006045056A3 (en) Flavonoid composition for treating oral diseases
Sajjan et al. Chlorhexidine as an antimicrobial agent in dentistry–a review
WO2003043517A3 (en) Dentifrice compositions
MXPA04002381A (en) Stable oral care compositions comprising chlorite.
JP2008517069A5 (en)
WO2005030141A3 (en) Morinda citrifolia-based oral care compositions and methods
JPH06505745A (en) Non-antibacterial tetracycline composition with anti-plaque properties
Torres‐Rouff Oral implications of labret use: a case from pre‐Columbian Chile
JPH06157259A (en) Composition for oral cavity
KR102337982B1 (en) Toothpaste composition containing hemp seed oil as an active ingredient
PL360850A1 (en) Use of exogenous lactic bacteria strain against actinomyces naeslundii
Fatemeh et al. Study of the effects of natural toothbrush (Salva-dora persica) in prevention of dental caries and plaque index
KR20190087701A (en) Anti-ache toothpaste containing extracts from hemp seed and yam
Radnai et al. Removable partial denture with bar or plate: How should we decide?
JP2005531556A (en) Composition for promoting oral hygiene
Deswal et al. Miswak as an alternative treatment modality in medicine and dentistry: a review
KR101875191B1 (en) Composition for mouth comprising tengcha
Akaji et al. Ethnopharmacological applications of chewing sticks on oral health care
KR20170037230A (en) Oral composition comprising cassava extract
KR100715186B1 (en) A composition for mouth comprising geniposide as active ingredient
CN106267157B (en) Composition for preventing or/and treating periodontal diseases and application thereof
Wood The effects of selected dietary bioflavonoid supplementation on dental caries in young rats fed a high-sucrose diet
JPH08245353A (en) Oral cavity composition
KR100963301B1 (en) Toothpaste composition comprising hemp fiber
Pawar et al. DANTADHAVANA AN AYURVEDIC APPROACH IN MAINTANCE OF ORAL HEALTH-A REVIEW

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005295190

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2005810437

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/004471

Country of ref document: MX

Ref document number: 12007500808

Country of ref document: PH

Ref document number: 2584124

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 554517

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2007538073

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 1579/KOLNP/2007

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 1020077011409

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2007118535

Country of ref document: RU

WWE Wipo information: entry into national phase

Ref document number: 200580043644.8

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2005810437

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0518218

Country of ref document: BR