BRPI0518205A - uso de (4'-trifluorometilfenil)-amida de ácido (z)-2-ciano-3-hidróxi-but-2-enóico para o tratamento de doença inflamatória do intestino - Google Patents
uso de (4'-trifluorometilfenil)-amida de ácido (z)-2-ciano-3-hidróxi-but-2-enóico para o tratamento de doença inflamatória do intestinoInfo
- Publication number
- BRPI0518205A BRPI0518205A BRPI0518205-0A BRPI0518205A BRPI0518205A BR PI0518205 A BRPI0518205 A BR PI0518205A BR PI0518205 A BRPI0518205 A BR PI0518205A BR PI0518205 A BRPI0518205 A BR PI0518205A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- inflammatory bowel
- bowel disease
- trifluoromethylphenyl
- cyano
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract 3
- UTNUDOFZCWSZMS-YFHOEESVSA-N teriflunomide Chemical compound C\C(O)=C(/C#N)C(=O)NC1=CC=C(C(F)(F)F)C=C1 UTNUDOFZCWSZMS-YFHOEESVSA-N 0.000 title 1
- BMEBUGFDWHDVHO-ARJAWSKDSA-N (z)-2-cyano-3-hydroxybut-2-enoic acid Chemical compound C\C(O)=C(/C#N)C(O)=O BMEBUGFDWHDVHO-ARJAWSKDSA-N 0.000 abstract 1
- ODGIMMLDVSWADK-UHFFFAOYSA-N 4-trifluoromethylaniline Chemical compound NC1=CC=C(C(F)(F)F)C=C1 ODGIMMLDVSWADK-UHFFFAOYSA-N 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62025504P | 2004-10-19 | 2004-10-19 | |
| PCT/US2005/037161 WO2006044741A1 (en) | 2004-10-19 | 2005-10-18 | Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518205A true BRPI0518205A (pt) | 2008-11-04 |
Family
ID=35636963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518205-0A BRPI0518205A (pt) | 2004-10-19 | 2005-10-18 | uso de (4'-trifluorometilfenil)-amida de ácido (z)-2-ciano-3-hidróxi-but-2-enóico para o tratamento de doença inflamatória do intestino |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070197643A1 (enExample) |
| EP (1) | EP1804782A1 (enExample) |
| JP (1) | JP2008517059A (enExample) |
| KR (1) | KR20070065888A (enExample) |
| CN (1) | CN101043883A (enExample) |
| AU (1) | AU2005295511A1 (enExample) |
| BR (1) | BRPI0518205A (enExample) |
| CA (1) | CA2584655A1 (enExample) |
| IL (1) | IL182591A0 (enExample) |
| MX (1) | MX2007004265A (enExample) |
| RU (1) | RU2007118691A (enExample) |
| SG (1) | SG142305A1 (enExample) |
| WO (1) | WO2006044741A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006268238A1 (en) | 2005-07-11 | 2007-01-18 | Medtronic Ablation Frontiers Llc | Low power tissue ablation system |
| ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
| EP2100881A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Pyrimidyl- or pyridinylaminobenzoic acid derivatives |
| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| EP2230232A1 (en) | 2009-03-13 | 2010-09-22 | Almirall, S.A. | Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors |
| EP2228367A1 (en) | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors |
| EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
| EP2277515A1 (en) * | 2009-07-10 | 2011-01-26 | Sanofi-Aventis | Use of the combination of teriflunomide and interferon beta for treating multiple sclerosis |
| HRP20170904T1 (hr) * | 2009-09-18 | 2017-09-08 | Sanofi | Formulacije tableta (4'-trifluormetilfenil)-amida (z)-2-cijano-3-hidroksi-but-2-enske kiseline s poboljšanom stabilnošću |
| EP2314577A1 (en) | 2009-10-16 | 2011-04-27 | Almirall, S.A. | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
| US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
| WO2012109329A2 (en) | 2011-02-08 | 2012-08-16 | Children's Medical Center Corporation | Methods for treatment of melanoma |
| JOP20190207A1 (ar) * | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| CN116725998A (zh) * | 2023-07-20 | 2023-09-12 | 中国科学技术大学 | 特立氟胺在抑制nlrp3炎症小体活化中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19547648A1 (de) * | 1995-12-20 | 1997-06-26 | Hoechst Ag | Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate |
| CA2328962A1 (en) * | 1998-04-17 | 1999-10-28 | Parker Hughes Institute | Btk inhibitors and methods for their identification and use |
| GB0005345D0 (en) * | 2000-03-06 | 2000-04-26 | Mathilda & Terence Kennedy Ins | Methods of treating sepsis septic shock and inflammation |
| CN1507354A (zh) * | 2001-03-02 | 2004-06-23 | ͨ��ҽ�ƹ�˾ | 通过给予整合蛋白αvβ3拮抗剂并与其它预防或治疗药剂配合来预防或者治疗炎性疾病或自身免疫疾病的方法 |
| ATE396719T1 (de) * | 2001-04-05 | 2008-06-15 | Aventis Pharma Inc | Verwendung von (z)-2-cyano-3-hydroxy-but-2- ensäure-(4'-trifluoromethylphenyl)-amid zur behandlung der multiplen sklerose |
| JP2005538165A (ja) * | 2002-09-06 | 2005-12-15 | シェボ ビオテック アクティエン ゲゼルシャフト | 解糖酵素及び／又はアミノ基転移酵素錯体調節用化合物 |
-
2005
- 2005-10-18 CN CNA2005800357982A patent/CN101043883A/zh active Pending
- 2005-10-18 MX MX2007004265A patent/MX2007004265A/es not_active Application Discontinuation
- 2005-10-18 WO PCT/US2005/037161 patent/WO2006044741A1/en not_active Ceased
- 2005-10-18 JP JP2007537944A patent/JP2008517059A/ja not_active Abandoned
- 2005-10-18 SG SG200802858-1A patent/SG142305A1/en unknown
- 2005-10-18 BR BRPI0518205-0A patent/BRPI0518205A/pt not_active IP Right Cessation
- 2005-10-18 AU AU2005295511A patent/AU2005295511A1/en not_active Abandoned
- 2005-10-18 RU RU2007118691/14A patent/RU2007118691A/ru not_active Application Discontinuation
- 2005-10-18 CA CA002584655A patent/CA2584655A1/en not_active Abandoned
- 2005-10-18 EP EP05812243A patent/EP1804782A1/en not_active Ceased
- 2005-10-18 KR KR1020077008909A patent/KR20070065888A/ko not_active Withdrawn
-
2007
- 2007-03-29 US US11/693,358 patent/US20070197643A1/en not_active Abandoned
- 2007-04-16 IL IL182591A patent/IL182591A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006044741A1 (en) | 2006-04-27 |
| CA2584655A1 (en) | 2006-04-27 |
| IL182591A0 (en) | 2007-09-20 |
| US20070197643A1 (en) | 2007-08-23 |
| CN101043883A (zh) | 2007-09-26 |
| SG142305A1 (en) | 2008-05-28 |
| EP1804782A1 (en) | 2007-07-11 |
| KR20070065888A (ko) | 2007-06-25 |
| JP2008517059A (ja) | 2008-05-22 |
| MX2007004265A (es) | 2008-03-04 |
| AU2005295511A1 (en) | 2006-04-27 |
| RU2007118691A (ru) | 2008-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: AVENTIS PHARMACEUTICALS, INC. (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |