BRPI0517135B1 - Composições e métodos para tratar doenças neoplásticas - Google Patents

Composições e métodos para tratar doenças neoplásticas Download PDF

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Publication number
BRPI0517135B1
BRPI0517135B1 BRPI0517135-0A BRPI0517135A BRPI0517135B1 BR PI0517135 B1 BRPI0517135 B1 BR PI0517135B1 BR PI0517135 A BRPI0517135 A BR PI0517135A BR PI0517135 B1 BRPI0517135 B1 BR PI0517135B1
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BR
Brazil
Prior art keywords
cancer
compound
cells
formula
compositions
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BRPI0517135-0A
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English (en)
Portuguese (pt)
Inventor
Kenneth C. Anderson
Dharminder Chauhan
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Triphase Research And Development I Corp
Dana-Farber Cancer Institute, Inc
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Application filed by Triphase Research And Development I Corp, Dana-Farber Cancer Institute, Inc filed Critical Triphase Research And Development I Corp
Publication of BRPI0517135A publication Critical patent/BRPI0517135A/pt
Publication of BRPI0517135B1 publication Critical patent/BRPI0517135B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0517135-0A 2004-12-03 2005-12-02 Composições e métodos para tratar doenças neoplásticas BRPI0517135B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63316104P 2004-12-03 2004-12-03
US60/633,161 2004-12-03
PCT/US2005/043668 WO2006060676A1 (fr) 2004-12-03 2005-12-02 Compositions et procedes destines au traitement des maladies neoplastiques

Publications (2)

Publication Number Publication Date
BRPI0517135A BRPI0517135A (pt) 2008-09-30
BRPI0517135B1 true BRPI0517135B1 (pt) 2022-04-19

Family

ID=36118298

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517135-0A BRPI0517135B1 (pt) 2004-12-03 2005-12-02 Composições e métodos para tratar doenças neoplásticas

Country Status (18)

Country Link
US (5) US20070225350A1 (fr)
EP (1) EP1830838B1 (fr)
JP (3) JP5676071B2 (fr)
KR (1) KR101282191B1 (fr)
CN (2) CN101155582B (fr)
AU (1) AU2005311709B2 (fr)
BR (1) BRPI0517135B1 (fr)
CA (1) CA2588923C (fr)
DK (1) DK1830838T3 (fr)
ES (1) ES2396762T3 (fr)
HK (1) HK1113462A1 (fr)
IL (3) IL183506A (fr)
MX (1) MX2007006526A (fr)
NZ (1) NZ555439A (fr)
PL (1) PL1830838T3 (fr)
SG (1) SG157365A1 (fr)
WO (1) WO2006060676A1 (fr)
ZA (1) ZA200704402B (fr)

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ZA200704402B (en) 2008-07-30
JP2012236862A (ja) 2012-12-06
US8722724B2 (en) 2014-05-13
CA2588923C (fr) 2015-02-03
US20230210817A1 (en) 2023-07-06
KR101282191B1 (ko) 2013-07-08
US20140349965A1 (en) 2014-11-27
CN101155582B (zh) 2013-04-24
KR20080003306A (ko) 2008-01-07
JP5837469B2 (ja) 2015-12-24
ES2396762T3 (es) 2013-02-26
EP1830838A1 (fr) 2007-09-12
US20070225350A1 (en) 2007-09-27
IL236426A0 (en) 2015-02-26
JP2008521928A (ja) 2008-06-26
US10610517B2 (en) 2020-04-07
IL183506A0 (en) 2007-10-31
JP2015028089A (ja) 2015-02-12
BRPI0517135A (pt) 2008-09-30
NZ555439A (en) 2010-12-24
US20090036390A1 (en) 2009-02-05
IL236426B (en) 2019-11-28
JP5963830B2 (ja) 2016-08-03
PL1830838T3 (pl) 2013-07-31
WO2006060676A1 (fr) 2006-06-08
HK1113462A1 (en) 2008-10-03
AU2005311709A1 (en) 2006-06-08
IL241756A0 (en) 2015-11-30
IL183506A (en) 2015-10-29
CN103230394A (zh) 2013-08-07
DK1830838T3 (da) 2013-01-21
JP5676071B2 (ja) 2015-02-25
AU2005311709B2 (en) 2011-07-28
EP1830838B1 (fr) 2012-10-03
SG157365A1 (en) 2009-12-29
CN101155582A (zh) 2008-04-02
CA2588923A1 (fr) 2006-06-08
US20200206190A1 (en) 2020-07-02
CN103230394B (zh) 2016-04-20

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