BRPI0517058A - agonistas e antagonistas do receptor acoplado à proteìna g e métodos de uso - Google Patents

agonistas e antagonistas do receptor acoplado à proteìna g e métodos de uso

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Publication number
BRPI0517058A
BRPI0517058A BRPI0517058-3A BRPI0517058A BRPI0517058A BR PI0517058 A BRPI0517058 A BR PI0517058A BR PI0517058 A BRPI0517058 A BR PI0517058A BR PI0517058 A BRPI0517058 A BR PI0517058A
Authority
BR
Brazil
Prior art keywords
antagonists
protein
methods
receptor agonists
coupled receptor
Prior art date
Application number
BRPI0517058-3A
Other languages
English (en)
Inventor
Lidjia Covic
Nicole Kaneider
Athan Kuliopulos
Original Assignee
New England Medical Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Medical Center Inc filed Critical New England Medical Center Inc
Publication of BRPI0517058A publication Critical patent/BRPI0517058A/pt

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

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Abstract

AGONISTAS E ANTAGONISTAS DO RECEPTOR ACOPLADO à PROTEìNA G E MéTODOS DE USO. A presente invenção relata de um modo geral receptores acoplados à proteína G (GPCRs) e, em particular, agonistas e antagonistas GPCR, uso destes compostos e de suas composições farmacêuticas, como por exemplo, no tratamento, modulação e/ou prevenção de condições fisiológicas asociadas a GPCRs, tais como no tratamento de condições nas quais receptores de quimiocina fazem parte, por exemplo, sépsis, artrite, inflamação e doenças autoimunes.
BRPI0517058-3A 2004-11-04 2005-11-04 agonistas e antagonistas do receptor acoplado à proteìna g e métodos de uso BRPI0517058A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62570604P 2004-11-04 2004-11-04
PCT/US2005/039959 WO2006052723A2 (en) 2004-11-04 2005-11-04 G protein coupled receptor agonists and antagonists and methods of use

Publications (1)

Publication Number Publication Date
BRPI0517058A true BRPI0517058A (pt) 2008-09-30

Family

ID=36337020

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517058-3A BRPI0517058A (pt) 2004-11-04 2005-11-04 agonistas e antagonistas do receptor acoplado à proteìna g e métodos de uso

Country Status (10)

Country Link
US (1) US8440627B2 (pt)
EP (2) EP2380904A1 (pt)
JP (2) JP2008519039A (pt)
CN (1) CN101094866A (pt)
AU (2) AU2005304963C1 (pt)
BR (1) BRPI0517058A (pt)
CA (1) CA2586344C (pt)
IL (1) IL182947A0 (pt)
RU (1) RU2430113C2 (pt)
WO (1) WO2006052723A2 (pt)

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US8440627B2 (en) 2013-05-14
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AU2005304963B2 (en) 2010-03-04
AU2010202328B2 (en) 2012-12-13
WO2006052723A3 (en) 2006-09-08
JP2008519039A (ja) 2008-06-05
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CN101094866A (zh) 2007-12-26
US20080214451A1 (en) 2008-09-04
CA2586344C (en) 2013-05-28
RU2007120594A (ru) 2008-12-10
EP2380904A1 (en) 2011-10-26
EP1814911A2 (en) 2007-08-08
CA2586344A1 (en) 2006-05-18
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AU2005304963A1 (en) 2006-05-18
AU2010202328A1 (en) 2010-07-01

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