BRPI0515976A - expandases mutantes - Google Patents
expandases mutantesInfo
- Publication number
- BRPI0515976A BRPI0515976A BRPI0515976-8A BRPI0515976A BRPI0515976A BR PI0515976 A BRPI0515976 A BR PI0515976A BR PI0515976 A BRPI0515976 A BR PI0515976A BR PI0515976 A BRPI0515976 A BR PI0515976A
- Authority
- BR
- Brazil
- Prior art keywords
- mutant
- expandase
- activity
- polypeptide
- expansion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
Abstract
A presente invenção está relacionada à expandade mutante que é uma variante de um polipeptídeo-modelo com atividade de expandase em que a expandase mutante tem uma atividade de expandase in vitro aumentada em pelo menos 2 vezes contra adipil-6-APA, em comparação com o polipeptídeo-modele com atividade de expandase.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04105022 | 2004-10-13 | ||
EP05106347 | 2005-07-12 | ||
PCT/EP2005/055148 WO2006040313A2 (en) | 2004-10-13 | 2005-10-11 | Mutant expandases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515976A true BRPI0515976A (pt) | 2008-08-12 |
Family
ID=35840672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515976-8A BRPI0515976A (pt) | 2004-10-13 | 2005-10-11 | expandases mutantes |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1799817B1 (pt) |
KR (1) | KR20070073779A (pt) |
CN (1) | CN101040043B (pt) |
BR (1) | BRPI0515976A (pt) |
ES (1) | ES2395945T3 (pt) |
WO (1) | WO2006040313A2 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104805047B (zh) * | 2014-01-23 | 2017-09-22 | 中国科学院微生物研究所 | 产头孢菌素g的重组菌及其构建方法与应用 |
CN107304418B (zh) | 2016-04-18 | 2022-08-26 | 百瑞全球有限公司 | 青霉素扩环酶突变体、编码该突变体的dna、含有该突变体的试剂盒及其应用 |
CN107557348B (zh) * | 2016-07-01 | 2022-07-08 | 百瑞全球有限公司 | 头孢菌素羟化酶突变体、编码该突变体的dna、使用该突变体的方法及其应用 |
CN112852913B (zh) * | 2020-04-17 | 2021-12-10 | 中国科学院天津工业生物技术研究所 | 脱乙酰氧头孢菌素C合成酶突变体及其在β-内酰胺抗生素母核合成中的应用 |
CN113234093A (zh) * | 2021-04-13 | 2021-08-10 | 伊犁川宁生物技术股份有限公司 | 一种3-去乙酰氧基头孢菌素c钠盐及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK282624B6 (sk) * | 1993-07-30 | 2002-10-08 | Dsm N. V. | Spôsob výroby a izolácie 7-aminodesacetoxycefalosporánovej kyseliny |
WO1997020053A2 (en) * | 1995-11-27 | 1997-06-05 | Gist-Brocades B.V. | Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin g |
AU4114697A (en) * | 1996-07-16 | 1998-02-09 | Gist-Brocades B.V. | Improved process for the production of adipoyl cephalosporins |
GB0011185D0 (en) * | 2000-05-09 | 2000-06-28 | Synpac Pharmaceuticals Limited | Protein |
-
2005
- 2005-10-11 BR BRPI0515976-8A patent/BRPI0515976A/pt not_active IP Right Cessation
- 2005-10-11 EP EP05801289A patent/EP1799817B1/en active Active
- 2005-10-11 ES ES05801289T patent/ES2395945T3/es active Active
- 2005-10-11 WO PCT/EP2005/055148 patent/WO2006040313A2/en active Application Filing
- 2005-10-11 CN CN200580034984.4A patent/CN101040043B/zh active Active
- 2005-10-11 KR KR1020077008435A patent/KR20070073779A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20070073779A (ko) | 2007-07-10 |
CN101040043A (zh) | 2007-09-19 |
ES2395945T3 (es) | 2013-02-18 |
EP1799817A2 (en) | 2007-06-27 |
WO2006040313A3 (en) | 2006-10-19 |
WO2006040313A2 (en) | 2006-04-20 |
CN101040043B (zh) | 2014-05-28 |
EP1799817B1 (en) | 2012-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |