BRPI0508430A - processo para a preparação de inibidores da triptase - Google Patents
processo para a preparação de inibidores da triptaseInfo
- Publication number
- BRPI0508430A BRPI0508430A BRPI0508430-0A BRPI0508430A BRPI0508430A BR PI0508430 A BRPI0508430 A BR PI0508430A BR PI0508430 A BRPI0508430 A BR PI0508430A BR PI0508430 A BRPI0508430 A BR PI0508430A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- tryptase inhibitors
- compounds
- intermediates
- processes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002750 tryptase inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04004799A EP1571150A1 (en) | 2004-03-02 | 2004-03-02 | Process for the preparation of tryptase inhibitors |
| US58574504P | 2004-07-06 | 2004-07-06 | |
| PCT/EP2005/001676 WO2005095385A1 (en) | 2004-03-02 | 2005-02-18 | Process for the preparation of tryptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0508430A true BRPI0508430A (pt) | 2007-07-24 |
Family
ID=34745976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0508430-0A BRPI0508430A (pt) | 2004-03-02 | 2005-02-18 | processo para a preparação de inibidores da triptase |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20130225825A1 (enExample) |
| EP (2) | EP1571150A1 (enExample) |
| JP (1) | JP4851440B2 (enExample) |
| CN (2) | CN1950362B (enExample) |
| AT (1) | ATE447567T1 (enExample) |
| AU (1) | AU2005229319B2 (enExample) |
| BR (1) | BRPI0508430A (enExample) |
| CA (1) | CA2557391C (enExample) |
| DK (1) | DK1723140T3 (enExample) |
| ES (1) | ES2334245T3 (enExample) |
| NZ (1) | NZ549224A (enExample) |
| PL (1) | PL1723140T3 (enExample) |
| PT (1) | PT1723140E (enExample) |
| RS (1) | RS51144B (enExample) |
| RU (1) | RU2378271C2 (enExample) |
| SI (1) | SI1723140T1 (enExample) |
| TN (1) | TNSN06260A1 (enExample) |
| UA (1) | UA85701C2 (enExample) |
| WO (1) | WO2005095385A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200840566A (en) * | 2006-12-22 | 2008-10-16 | Esteve Labor Dr | Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments |
| EP2224803B1 (en) * | 2007-11-21 | 2014-04-02 | Janssen Pharmaceutica N.V. | Spiropiperidines for use as tryptase inhibitors |
| CN103508936A (zh) * | 2008-08-22 | 2014-01-15 | 赛诺菲-安万特 | 用于制备吲哚苄胺化合物的中间体 |
| WO2011037947A1 (en) * | 2009-09-24 | 2011-03-31 | Sanofi-Aventis U.S. Llc | Synthesis of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester and intermediates thereof |
| JP2013515723A (ja) * | 2009-12-23 | 2013-05-09 | サノフイ | 炎症性腸疾患の処置 |
| US20140113934A1 (en) | 2011-06-20 | 2014-04-24 | E I Du Pont De Nemours And Company | Heterocyclic compounds for treating helminth infections |
| JP2015502936A (ja) | 2011-11-28 | 2015-01-29 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | スルホンアミド駆虫薬 |
| WO2014099837A1 (en) | 2012-12-18 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Sulfonamide anthelmintics |
| CN111793101B (zh) | 2020-07-17 | 2022-09-30 | 四川大学 | C-核苷化合物的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0401166B1 (de) * | 1989-06-01 | 1995-02-22 | Ciba-Geigy Ag | Neue, stickstoffhaltige Titanocene und deren Verwendung |
| US5252753A (en) * | 1991-11-01 | 1993-10-12 | Ortho Pharmaceutical Corporation | Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof |
| IL122072A (en) * | 1996-11-14 | 2001-03-19 | Akzo Nobel Nv | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
| WO1999018053A1 (en) * | 1997-10-02 | 1999-04-15 | The University Of Western Ontario | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
| US20020045613A1 (en) * | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
| DZ3347A1 (fr) * | 2000-05-22 | 2001-11-29 | Aventis Pharma Inc | Dérivés d'arylméthylamine pour leur utilisation comme inhibiteurs de la tryptase |
| JP4846238B2 (ja) * | 2002-10-18 | 2011-12-28 | マクマスター ユニバーシティー | 放射線標識した化合物の精製方法 |
| GB0308613D0 (en) * | 2002-12-26 | 2003-05-21 | Aventis Pharma Inc | 4-(3-Aminomethylphenyl) piperidin-1-yl- 5-(2-fluorophenylethynyl) furan-2-yl- methanone as an inhibitor of mast cell tryptase |
-
2004
- 2004-03-02 EP EP04004799A patent/EP1571150A1/en not_active Withdrawn
-
2005
- 2005-02-18 BR BRPI0508430-0A patent/BRPI0508430A/pt not_active IP Right Cessation
- 2005-02-18 JP JP2007501151A patent/JP4851440B2/ja not_active Expired - Fee Related
- 2005-02-18 EP EP05779890A patent/EP1723140B1/en not_active Expired - Lifetime
- 2005-02-18 UA UAA200610386A patent/UA85701C2/ru unknown
- 2005-02-18 RS RSP-2009/0532A patent/RS51144B/sr unknown
- 2005-02-18 AT AT05779890T patent/ATE447567T1/de active
- 2005-02-18 ES ES05779890T patent/ES2334245T3/es not_active Expired - Lifetime
- 2005-02-18 DK DK05779890.2T patent/DK1723140T3/da active
- 2005-02-18 NZ NZ549224A patent/NZ549224A/en not_active IP Right Cessation
- 2005-02-18 PT PT05779890T patent/PT1723140E/pt unknown
- 2005-02-18 RU RU2006134623/04A patent/RU2378271C2/ru not_active IP Right Cessation
- 2005-02-18 CN CN2005800140491A patent/CN1950362B/zh not_active Expired - Fee Related
- 2005-02-18 CN CN2008101787837A patent/CN101429194B/zh not_active Expired - Fee Related
- 2005-02-18 SI SI200530896T patent/SI1723140T1/sl unknown
- 2005-02-18 PL PL05779890T patent/PL1723140T3/pl unknown
- 2005-02-18 CA CA2557391A patent/CA2557391C/en not_active Expired - Fee Related
- 2005-02-18 AU AU2005229319A patent/AU2005229319B2/en not_active Ceased
- 2005-02-18 WO PCT/EP2005/001676 patent/WO2005095385A1/en not_active Ceased
-
2006
- 2006-08-15 TN TNP2006000260A patent/TNSN06260A1/en unknown
-
2013
- 2013-04-11 US US13/861,066 patent/US20130225825A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE447567T1 (de) | 2009-11-15 |
| RS51144B (sr) | 2010-10-31 |
| EP1723140A1 (en) | 2006-11-22 |
| CA2557391C (en) | 2011-06-28 |
| CN1950362A (zh) | 2007-04-18 |
| CN101429194B (zh) | 2011-12-14 |
| AU2005229319A1 (en) | 2005-10-13 |
| US20130225825A1 (en) | 2013-08-29 |
| PT1723140E (pt) | 2010-01-13 |
| JP4851440B2 (ja) | 2012-01-11 |
| NZ549224A (en) | 2010-10-29 |
| RU2378271C2 (ru) | 2010-01-10 |
| CN101429194A (zh) | 2009-05-13 |
| EP1571150A1 (en) | 2005-09-07 |
| RU2006134623A (ru) | 2008-04-10 |
| EP1723140B1 (en) | 2009-11-04 |
| ES2334245T3 (es) | 2010-03-08 |
| SI1723140T1 (sl) | 2010-02-26 |
| UA85701C2 (ru) | 2009-02-25 |
| AU2005229319B2 (en) | 2011-10-20 |
| WO2005095385A1 (en) | 2005-10-13 |
| DK1723140T3 (da) | 2010-03-22 |
| CN1950362B (zh) | 2010-08-04 |
| PL1723140T3 (pl) | 2010-02-26 |
| CA2557391A1 (en) | 2005-10-13 |
| JP2007526264A (ja) | 2007-09-13 |
| TNSN06260A1 (en) | 2007-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: AVENTIS PHARMACEUTICALS, INC. (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2364 DE 26-04-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |