BRPI0501091A - comprimido de domperidona rapidamente dispersìvel em água - Google Patents

comprimido de domperidona rapidamente dispersìvel em água

Info

Publication number
BRPI0501091A
BRPI0501091A BRPI0501091-8A BRPI0501091A BRPI0501091A BR PI0501091 A BRPI0501091 A BR PI0501091A BR PI0501091 A BRPI0501091 A BR PI0501091A BR PI0501091 A BRPI0501091 A BR PI0501091A
Authority
BR
Brazil
Prior art keywords
water
domperidone
minutes
dispersion
fast
Prior art date
Application number
BRPI0501091-8A
Other languages
English (en)
Inventor
Maria Julia Caeiro Ramalho
Micul Hasmuklal Mulchande
Original Assignee
Medinfar Produtos Farmaceutico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medinfar Produtos Farmaceutico filed Critical Medinfar Produtos Farmaceutico
Publication of BRPI0501091A publication Critical patent/BRPI0501091A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

"COMPRIMIDO DE DOMPERIDONA RAPIDAMENTE DISPERSìVEL EM áGUA". A presente invenção relaciona-se com comprimidos contendo domperidona rapidamente dispersíveis em água para administração oral. As formulações compreendem domperidona ou os seus sais farmaceuticamente aceitáveis, cerca de 60 80 % de granulado 'auxiliar' (p/p) e cerca de 10 - 30 % de celulose microcristalina (p/p), expressos em relação ao peso total dos comprimidos, um edulcorante, um agente aromatizante e um lubrificante. O granulado 'auxiliar' é obtido por granulação a húmido de D-manitol e goma de amido de milho num granulador rápido, facilita o escoamento e a compressibilidade da mistura e, devido à sua elevada solubilidade em água, contribui para a rápida dispersão do comprimido. As formulações têm uma integridade estrutural melhorada tendo, por exemplo, uma friabilidade inferior a 1,0 % e valores de dureza entre 3 and 6 Kp, e são capazes de dispersar-se em água em 3 minutos, preferencialmente em 2 minutos e mais preferencialmente em 1 minuto, para originar uma dispersão que passa através de um tamis com 710 gm de diâmetro de malha e que apresenta um sabor agradável e ausência de grânulos perceptíveis na boca. Esta invenção refere-se também ao processo de preparação das referidas formulações.
BRPI0501091-8A 2004-09-09 2005-01-31 comprimido de domperidona rapidamente dispersìvel em água BRPI0501091A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04398007A EP1634586B1 (en) 2004-09-09 2004-09-09 Fast water-dispersible domperidone tablets

Publications (1)

Publication Number Publication Date
BRPI0501091A true BRPI0501091A (pt) 2006-04-18

Family

ID=34932031

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0501091-8A BRPI0501091A (pt) 2004-09-09 2005-01-31 comprimido de domperidona rapidamente dispersìvel em água

Country Status (10)

Country Link
US (1) US7494668B2 (pt)
EP (1) EP1634586B1 (pt)
AT (1) ATE353635T1 (pt)
BR (1) BRPI0501091A (pt)
DE (1) DE602004004782T2 (pt)
ES (1) ES2282831T3 (pt)
HK (1) HK1087948A1 (pt)
MA (1) MA27816A1 (pt)
PL (1) PL1634586T3 (pt)
PT (1) PT1634586E (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050244492A1 (en) * 2004-04-30 2005-11-03 Mehra Dev K Rapidly disintegrating tablets comprising titanium dioxide
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
FR2909877B1 (fr) * 2006-12-13 2009-07-10 Galenix Dev Soc Par Actions Si Composition pharmaceutique contenat de la 5-chloro-1-[1-[3- (2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl] piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one et son procede de preparation
WO2008134540A1 (en) * 2007-04-26 2008-11-06 Aronchick Craig A Compositions and methods for transmucosal delivery of domperidone
TWI349410B (en) * 2008-01-08 2011-09-21 Novatek Microelectronics Corp Change pump circuit
US20110027374A1 (en) * 2008-12-16 2011-02-03 Maria Oksana Bachynsky Capecitabine rapidly disintegrating tablets
ES2742525T3 (es) 2009-10-01 2020-02-14 Adare Pharmaceuticals Us L P Composiciones de corticosteroides administradas oralmente
WO2015034678A2 (en) * 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
CN104127390B (zh) * 2014-08-05 2016-05-11 孙丽华 一种多潘立酮片及其制备工艺
TWI728172B (zh) 2016-08-18 2021-05-21 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
AU2018297656B2 (en) * 2017-07-05 2021-09-16 Novartis Ag Novel pharmaceutical composition
CN115462495A (zh) * 2022-09-06 2022-12-13 江苏艾兰得营养品有限公司 一种微泡腾片及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
DE19931708A1 (de) * 1999-07-08 2001-01-18 Bayer Ag Verfahren zur Herstellung schnell zerfallender, fester pharmazeutischer Zubereitungen
US20030185886A1 (en) * 2000-05-26 2003-10-02 Hanmi Pharm. Co., Ltd. Process for the preparation of rapidly disintegrating tablet
CA2449731A1 (en) * 2001-06-07 2002-12-19 Tanabe Seiyaku Co., Ltd. Functional grain-containing preparations quickly disintegrated in the oral cavity
WO2003086343A2 (en) * 2002-04-05 2003-10-23 Cadila Healthcare Limited Fast disintegrating oral dosage forms

Also Published As

Publication number Publication date
DE602004004782T2 (de) 2007-10-31
PL1634586T3 (pl) 2007-07-31
ES2282831T3 (es) 2007-10-16
DE602004004782D1 (de) 2007-03-29
EP1634586B1 (en) 2007-02-14
HK1087948A1 (en) 2006-10-27
US20060051414A1 (en) 2006-03-09
MA27816A1 (fr) 2006-04-03
US7494668B2 (en) 2009-02-24
EP1634586A1 (en) 2006-03-15
ATE353635T1 (de) 2007-03-15
PT1634586E (pt) 2007-04-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2086 DE 28/12/2010.