BRPI0416854B8 - suspensão aquosa estéril de ciclesonida adequada para nebulização, método para sua preparação e uso da dita suspensão, bem como produto farmacêutico - Google Patents
suspensão aquosa estéril de ciclesonida adequada para nebulização, método para sua preparação e uso da dita suspensão, bem como produto farmacêuticoInfo
- Publication number
- BRPI0416854B8 BRPI0416854B8 BRPI0416854A BRPI0416854A BRPI0416854B8 BR PI0416854 B8 BRPI0416854 B8 BR PI0416854B8 BR PI0416854 A BRPI0416854 A BR PI0416854A BR PI0416854 A BRPI0416854 A BR PI0416854A BR PI0416854 B8 BRPI0416854 B8 BR PI0416854B8
- Authority
- BR
- Brazil
- Prior art keywords
- suspension
- nebulization
- sterile aqueous
- ciclesonide
- preparation
- Prior art date
Links
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 title abstract 4
- 239000007900 aqueous suspension Substances 0.000 title abstract 4
- 229960003728 ciclesonide Drugs 0.000 title abstract 4
- 238000002663 nebulization Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03028848.4 | 2003-12-16 | ||
| EP03028848 | 2003-12-16 | ||
| PCT/EP2004/053495 WO2005058935A2 (en) | 2003-12-16 | 2004-12-15 | Aqueous suspensions of ciclesonide for nebulisation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0416854A BRPI0416854A (pt) | 2007-02-13 |
| BRPI0416854B1 BRPI0416854B1 (pt) | 2018-05-02 |
| BRPI0416854B8 true BRPI0416854B8 (pt) | 2021-05-25 |
Family
ID=34684543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416854A BRPI0416854B8 (pt) | 2003-12-16 | 2004-12-15 | suspensão aquosa estéril de ciclesonida adequada para nebulização, método para sua preparação e uso da dita suspensão, bem como produto farmacêutico |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20070117783A1 (https=) |
| EP (2) | EP2319858B1 (https=) |
| JP (1) | JP5001657B2 (https=) |
| KR (1) | KR101086095B1 (https=) |
| CN (1) | CN100513417C (https=) |
| AR (1) | AR046892A1 (https=) |
| AU (1) | AU2004298447B2 (https=) |
| BR (1) | BRPI0416854B8 (https=) |
| CA (1) | CA2549038C (https=) |
| CO (1) | CO5700832A2 (https=) |
| EA (1) | EA012388B1 (https=) |
| EC (1) | ECSP066608A (https=) |
| IL (1) | IL175461A (https=) |
| MY (1) | MY159377A (https=) |
| NO (1) | NO337225B1 (https=) |
| NZ (1) | NZ547217A (https=) |
| PE (1) | PE20050941A1 (https=) |
| TW (1) | TWI350757B (https=) |
| UA (1) | UA87123C2 (https=) |
| WO (1) | WO2005058935A2 (https=) |
| ZA (1) | ZA200603768B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2022796A1 (en) * | 2007-08-07 | 2009-02-11 | Nycomed GmbH | Amorphous ciclesonide |
| US7984792B2 (en) * | 2008-03-03 | 2011-07-26 | Rolls-Royce Corporation | Lubrication system |
| CN102238958A (zh) * | 2008-12-03 | 2011-11-09 | 日本株式会社Ltt生物医药 | 含有修饰型超氧化物歧化酶的吸入剂 |
| CA3004707C (en) | 2009-09-02 | 2022-05-31 | Synedgen Inc. | Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| JP6021117B2 (ja) * | 2011-01-31 | 2016-11-02 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| AR089645A1 (es) | 2011-08-12 | 2014-09-10 | Boehringer Ingelheim Vetmed | Particula multicapas de sabor enmascarado, metodo, uso, composicion farmaceutica |
| US11007150B2 (en) | 2011-08-18 | 2021-05-18 | Covis Pharma Gmbh | Pharmaceutical aerosol product for administration by oral or nasal inhalation |
| MY168300A (en) | 2011-09-14 | 2018-10-25 | Shionogi & Co | Pharmaceutical Composition for Inhalation |
| HRP20181980T1 (hr) * | 2012-12-21 | 2019-01-25 | Boehringer Ingelheim Vetmedica Gmbh | Ciklezonid za liječenje dišnih puteva kod konja |
| US10925964B2 (en) | 2012-12-21 | 2021-02-23 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical formulation comprising ciclesonide |
| NZ760541A (en) | 2014-01-10 | 2022-08-26 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| MX370430B (es) | 2014-06-18 | 2019-12-13 | Boehringer Ingelheim Vetmedica Gmbh | Antagonistas muscarínicos y sus combinaciones para el tratamiento de enfermedades de las vías respiratorias en caballos. |
| WO2016040899A1 (en) * | 2014-09-11 | 2016-03-17 | Synedgen, Inc. | Compositions and methods of use thereof |
| HK1252798A1 (zh) * | 2015-08-05 | 2019-06-06 | Daiichi Sankyo Company, Limited | 喷雾器用组合物 |
| CN106692163A (zh) * | 2015-11-13 | 2017-05-24 | 天津金耀集团有限公司 | 一种吸入用环索奈德混悬液组合物 |
| WO2019090405A1 (pt) * | 2017-11-11 | 2019-05-16 | Carvalho Junior Mario Virgilio De | Medicamento de ciclesonida para cura e prevenção da gripe causada pelo vírus influenza |
| US20220023282A1 (en) * | 2018-12-13 | 2022-01-27 | Mannkind Corporation | Compositions of Bedaquiline, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them |
| EP4142740A4 (en) | 2020-04-30 | 2024-01-24 | Synedgen, Inc. | Compositions and methods of use thereof |
| US20210346613A1 (en) * | 2020-05-05 | 2021-11-11 | Mahesh Kumar KHAITAN | Controlled delivery device for treating coronavirus infections and methods thereof |
| WO2021262648A1 (en) * | 2020-06-23 | 2021-12-30 | Anovent Pharmaceutical (U.S.), Llc | Preparation of a pharmaceutical composition of olodaterol and budesonide |
| WO2022213101A1 (en) * | 2021-04-01 | 2022-10-06 | Vitrean Inc. | Methods for manufacturing of highly concentrated hydrogels |
| WO2022231533A1 (en) * | 2021-04-29 | 2022-11-03 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Process for the preparation of sterilized suspensions for the inhalation by nebulization |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE458986B (sv) * | 1985-03-29 | 1989-05-29 | Draco Ab | Dosfoerpackning |
| SE8600632D0 (sv) | 1986-02-13 | 1986-02-13 | Kabivitrum Ab | Novel pharmaceutical composition |
| GR1001529B (el) | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| US5346702A (en) * | 1992-12-04 | 1994-09-13 | Sterling Winthrop Inc. | Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization |
| UA45311C2 (uk) | 1993-04-02 | 2002-04-15 | Бік Гульден Ломберг Хеміше Фабрік Гмбх | 16<font face="Symbol">a</font>,17-ЦИКЛОГЕКСИЛМЕТИЛЕНДІОКСИ-11<font face="Symbol">b</font>,21-ДИГІДРОКСИПРЕГНА-1,4-ДІЄН-3,20-ДІОН, СПОСІБ ЙОГО ОДЕРЖАННЯ, ЛІКАРСЬКИЙ ЗАСІБ |
| US5540930A (en) * | 1993-10-25 | 1996-07-30 | Pharmos Corporation | Suspension of loteprednol etabonate for ear, eye, or nose treatment |
| GB9410222D0 (en) | 1994-05-21 | 1994-07-06 | Glaxo Wellcome Australia Ltd | Medicaments |
| DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| DE19541689A1 (de) | 1994-11-14 | 1996-05-15 | Byk Gulden Lomberg Chem Fab | Kombinationsarzneimittel |
| DE19635498A1 (de) | 1996-09-03 | 1998-03-26 | Byk Gulden Lomberg Chem Fab | Verfahren zur Epimerenanreicherung |
| US6120752A (en) | 1997-05-21 | 2000-09-19 | 3M Innovative Properties Company | Medicinal aerosol products containing formulations of ciclesonide and related steroids |
| SE9704186D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
| US6598603B1 (en) * | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
| TWI243687B (en) * | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
| US6264923B1 (en) * | 1998-05-13 | 2001-07-24 | 3M Innovative Properties Company | Medicinal aerosol formulation of ciclesonide and related compounds |
| HK1039458B (zh) | 1998-05-29 | 2006-09-01 | Skyepharma Canada Inc. | 熱保護微粒組合物及其最終蒸汽滅菌的方法 |
| US6241969B1 (en) * | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| IT1303692B1 (it) | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
| IT1313553B1 (it) * | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
| AR026073A1 (es) * | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica acuosa que contiene ciclesonida |
| AR026072A1 (es) * | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica que contiene ciclesonida para aplicacion a la mucosa |
| AU7947600A (en) | 1999-10-20 | 2001-04-30 | Teijin Limited | Aqueous medicinal compositions |
| US20020183292A1 (en) * | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
| DE10062712A1 (de) * | 2000-12-15 | 2002-06-20 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden |
| BR0115584A (pt) * | 2000-11-24 | 2003-09-23 | Breath Ltd | Esterilização de produtos farmacêuticos |
| US6667344B2 (en) * | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| US20030055026A1 (en) * | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| DE10145361A1 (de) * | 2001-09-14 | 2003-04-03 | Pari Gmbh | Verfahren zur Herstellung von flüssigen, sterilen Zubereitungen zur Inhalation |
| JP2005508220A (ja) | 2001-10-24 | 2005-03-31 | パーリ・ゲーエムベーハー | 薬用組成物調製用具 |
| AU2003246829A1 (en) | 2002-02-19 | 2003-09-09 | Resolution Chemicals Limited | Solvent-based sterilisation of pharmaceuticals |
| CA2478636A1 (en) | 2002-03-04 | 2003-09-12 | Nymox Corporation | Spheron components useful in determining compounds capable of treating symptoms of alzheimer's disease, and treatments and animal models produced therefrom |
| KR101030922B1 (ko) | 2002-04-12 | 2011-04-27 | 아지노모토 가부시키가이샤 | 동맥경화 예방용 조성물 |
| ITMI20020808A1 (it) * | 2002-04-17 | 2003-10-17 | Chiesi Farma Spa | Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione |
| BRPI0312377A8 (pt) * | 2002-07-02 | 2015-12-15 | Altana Pharma Ag | Suspensão aquosa estéril contendo ciclesonida |
| JP4364486B2 (ja) | 2002-07-02 | 2009-11-18 | 帝人株式会社 | 無菌水性懸濁製剤 |
| US20040023935A1 (en) * | 2002-08-02 | 2004-02-05 | Dey, L.P. | Inhalation compositions, methods of use thereof, and process for preparation of same |
| DE60333205D1 (de) * | 2002-08-30 | 2010-08-12 | Nycomed Gmbh | Histaminika zur behandlung von allergischer rhinitis |
| WO2004029574A1 (ja) | 2002-09-24 | 2004-04-08 | Fujitsu Limited | 歪み波形制御装置、歪み規制部材、歪み波形制御装置の歪み波形制御方法、及び歪み波形制御プログラム |
| US20040105778A1 (en) | 2002-10-04 | 2004-06-03 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
| ITMI20022674A1 (it) * | 2002-12-18 | 2004-06-19 | Chiesi Farma Spa | Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione. |
| EP1454636A1 (en) | 2003-03-04 | 2004-09-08 | Dompé S.P.A. | Sterilization of glucocorticoid drug particles for pulmonary delivery |
| MY143936A (en) | 2003-03-27 | 2011-07-29 | Nycomed Gmbh | Process for preparing crystalline ciclesonide with defined particle size |
| TWI359675B (en) * | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| AU2004271744B2 (en) * | 2003-09-16 | 2010-07-29 | Covis Pharma B.V. | Use of ciclesonide for the treatment of respiratory diseases |
| DE10347994A1 (de) * | 2003-10-15 | 2005-06-16 | Pari GmbH Spezialisten für effektive Inhalation | Wässrige Aerosol-Zubereitung |
| US7892483B2 (en) | 2004-03-12 | 2011-02-22 | Cipla Limited | Sterilization process |
| GB0410995D0 (en) | 2004-05-17 | 2004-06-23 | Norton Healthcare Ltd | Heat sterilization of glucocorticosteroids |
| ITSA20040012A1 (it) | 2004-09-07 | 2004-12-07 | Genetec S P A | Processo di sterilizzazione di un glucocorticosteroide. |
| GB0425266D0 (en) | 2004-11-16 | 2004-12-15 | Norton Healthcare Ltd | Pharmaceutical manufacturing process |
-
2004
- 2004-12-10 PE PE2004001247A patent/PE20050941A1/es active IP Right Grant
- 2004-12-14 MY MYPI20045134A patent/MY159377A/en unknown
- 2004-12-15 BR BRPI0416854A patent/BRPI0416854B8/pt active IP Right Grant
- 2004-12-15 JP JP2006544438A patent/JP5001657B2/ja not_active Expired - Lifetime
- 2004-12-15 EA EA200601091A patent/EA012388B1/ru not_active IP Right Cessation
- 2004-12-15 EP EP10173237.8A patent/EP2319858B1/en not_active Expired - Lifetime
- 2004-12-15 CA CA2549038A patent/CA2549038C/en not_active Expired - Fee Related
- 2004-12-15 CN CNB2004800368287A patent/CN100513417C/zh not_active Expired - Lifetime
- 2004-12-15 AR ARP040104661A patent/AR046892A1/es not_active Application Discontinuation
- 2004-12-15 US US10/582,499 patent/US20070117783A1/en not_active Abandoned
- 2004-12-15 NZ NZ547217A patent/NZ547217A/en not_active IP Right Cessation
- 2004-12-15 EP EP04804847A patent/EP1697398B1/en not_active Expired - Lifetime
- 2004-12-15 AU AU2004298447A patent/AU2004298447B2/en not_active Expired
- 2004-12-15 UA UAA200607589A patent/UA87123C2/uk unknown
- 2004-12-15 WO PCT/EP2004/053495 patent/WO2005058935A2/en not_active Ceased
- 2004-12-15 KR KR1020067013760A patent/KR101086095B1/ko not_active Expired - Lifetime
- 2004-12-16 TW TW093139206A patent/TWI350757B/zh not_active IP Right Cessation
-
2006
- 2006-05-07 IL IL175461A patent/IL175461A/en active IP Right Grant
- 2006-05-11 ZA ZA200603768A patent/ZA200603768B/en unknown
- 2006-06-05 EC EC2006006608A patent/ECSP066608A/es unknown
- 2006-06-07 CO CO06054801A patent/CO5700832A2/es active IP Right Grant
- 2006-06-30 NO NO20063047A patent/NO337225B1/no unknown
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2015
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