BRPI0416674A - tiazolidinona amidas, amidas de ácido tiazolidino carboxìlico, processos de fabricação, e uso das mesmas - Google Patents

tiazolidinona amidas, amidas de ácido tiazolidino carboxìlico, processos de fabricação, e uso das mesmas

Info

Publication number
BRPI0416674A
BRPI0416674A BRPI0416674-4A BRPI0416674A BRPI0416674A BR PI0416674 A BRPI0416674 A BR PI0416674A BR PI0416674 A BRPI0416674 A BR PI0416674A BR PI0416674 A BRPI0416674 A BR PI0416674A
Authority
BR
Brazil
Prior art keywords
carboxylic acid
amides
manufacturing processes
acid amides
thiazolidine carboxylic
Prior art date
Application number
BRPI0416674-4A
Other languages
English (en)
Inventor
Duane D Miller
Veeresa Gududuru
James T Dalton
Eunju Hurh
Original Assignee
Univ Tennessee Res Foundation
Univ Ohio State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tennessee Res Foundation, Univ Ohio State Res Found filed Critical Univ Tennessee Res Foundation
Publication of BRPI0416674A publication Critical patent/BRPI0416674A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"TIAZOLIDINONA AMIDAS, AMIDAS DE áCIDO TIAZOLIDINO CARBOXìLICO, PROCESSOS DE FABRICAçãO, E USO DAS MESMAS". Amidas de ácido tiazolidinono carboxílico substituídas e amidas de ácido tiazolidino carboxílico substituídas de acordo com as fórmulas (I) e (II) são mostradas onde os vários grupos substituintes são como definidos no relatório descritivo. Processos de fabricação destes compostos, composições farmacêuticas contendo os compostos, e seu uso, particularmente para tratamento ou prevenção de câncer, também são mostrados.
BRPI0416674-4A 2003-11-18 2004-11-18 tiazolidinona amidas, amidas de ácido tiazolidino carboxìlico, processos de fabricação, e uso das mesmas BRPI0416674A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52307903P 2003-11-18 2003-11-18
PCT/US2004/038662 WO2005049591A1 (en) 2003-11-18 2004-11-18 Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0416674A true BRPI0416674A (pt) 2007-02-13

Family

ID=34619564

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416674-4A BRPI0416674A (pt) 2003-11-18 2004-11-18 tiazolidinona amidas, amidas de ácido tiazolidino carboxìlico, processos de fabricação, e uso das mesmas

Country Status (11)

Country Link
US (3) US7307093B2 (pt)
EP (1) EP1692121A1 (pt)
JP (1) JP2007513090A (pt)
CN (1) CN1902184A (pt)
AU (1) AU2004291539A1 (pt)
BR (1) BRPI0416674A (pt)
CA (1) CA2546324A1 (pt)
EA (1) EA200600992A1 (pt)
IL (1) IL175633A0 (pt)
MX (1) MXPA06005528A (pt)
WO (1) WO2005049591A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06005528A (es) 2003-11-18 2007-01-30 Univ Tennessee Res Foundation Tiazolidinona-amidas, amidas de acido tiazolidina-carboxilico, metodos de elaboracion, y uso de las mismas.
WO2005054468A1 (ja) * 2003-12-01 2005-06-16 Reverse Proteomics Research Institute Co., Ltd. 抗糖尿病剤の標的タンパク質及び対応する新規抗糖尿病剤「インスフル」
WO2008036067A2 (en) * 2005-07-19 2008-03-27 The University Of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents
CN101421257A (zh) * 2006-03-21 2009-04-29 欧洲分子生物学实验室 阻断细胞复制的试剂以及它们在抑制病理状态中的用途
WO2008090356A1 (en) * 2007-01-25 2008-07-31 Betagenon Ab Thiazolidinone derivatives useful in the treatment of cancer and disorders caused by excess adiposity
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
MX2010014066A (es) 2008-06-16 2011-06-01 Univ Tennessee Res Foundation Compuestos para el tratamiento del cancer.
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
WO2011109059A1 (en) 2010-03-01 2011-09-09 Gtx, Inc. Compounds for treatment of cancer
WO2014138279A1 (en) 2013-03-05 2014-09-12 University Of Tennessee Research Foundation Compounds for treatment of cancer
WO2014145314A2 (en) 2013-03-15 2014-09-18 Cancer Research Technology, Llc Methods and compositions for gamma-glutamyl cycle modulation
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030415A (zh) 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
MX9704435A (es) 1994-12-15 1997-10-31 Sankyio Company Ltd Compuestos de tiazolidinona y agente terapeutico o agente de prevencion para angina de pecho, que comprende los compuestos como un ingrediente activo.
HU223094B1 (hu) 1995-03-02 2004-03-29 Sankyo Co., Ltd. Optikailag aktív tiazolidinonszármazékok, előállításuk, a vegyületeket hatóanyagként tartalmazó gyógyászati készítmények és tia-vagy oxazolidinonszármazékok alkalmazása gyógyászati készítmények előállítására
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
MXPA04009784A (es) 2002-04-08 2004-12-13 Torrent Pharmaceuticlas Ltd Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas.
US20060014740A1 (en) * 2003-11-18 2006-01-19 Miller Duane D Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof
MXPA06005528A (es) 2003-11-18 2007-01-30 Univ Tennessee Res Foundation Tiazolidinona-amidas, amidas de acido tiazolidina-carboxilico, metodos de elaboracion, y uso de las mismas.

Also Published As

Publication number Publication date
JP2007513090A (ja) 2007-05-24
US20070155807A1 (en) 2007-07-05
US7662842B2 (en) 2010-02-16
AU2004291539A1 (en) 2005-06-02
WO2005049591A1 (en) 2005-06-02
EP1692121A1 (en) 2006-08-23
CA2546324A1 (en) 2005-06-02
US20090143446A1 (en) 2009-06-04
EA200600992A1 (ru) 2006-10-27
CN1902184A (zh) 2007-01-24
MXPA06005528A (es) 2007-01-30
US7307093B2 (en) 2007-12-11
US20060040998A1 (en) 2006-02-23
IL175633A0 (en) 2006-09-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 5A, 6A E 7A ANUIDADES.