BRPI0416355A - métodos para avaliar o risco de um paciente desenvolver uma reação adversa a droga, para desenvolver uma terapia para uma reação adversa induzida por uma droga, para avaliar o risco de um paciente desenvolver sjs, ten ou hss, e para identificar uma droga que induz sjs, ten ou hss - Google Patents
métodos para avaliar o risco de um paciente desenvolver uma reação adversa a droga, para desenvolver uma terapia para uma reação adversa induzida por uma droga, para avaliar o risco de um paciente desenvolver sjs, ten ou hss, e para identificar uma droga que induz sjs, ten ou hssInfo
- Publication number
- BRPI0416355A BRPI0416355A BRPI0416355-9A BRPI0416355A BRPI0416355A BR PI0416355 A BRPI0416355 A BR PI0416355A BR PI0416355 A BRPI0416355 A BR PI0416355A BR PI0416355 A BRPI0416355 A BR PI0416355A
- Authority
- BR
- Brazil
- Prior art keywords
- sjs
- hla
- developing
- drug
- patient
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"MéTODOS PARA AVALIAR O RISCO DE UM PACIENTE DESENVOLVER UMA REAçãO ADVERSA A DROGA, PARA DESENVOLVER UMA TERAPIA PARA UMA REAçãO ADVERSA INDUZIDA POR UMA DROGA, PARA AVALIAR O RISCO DE UM PACIENTE DESENVOLVER SJS, TEN OU HSS, E PARA IDENTIFICAR UMA DROGA QUE INDUZ SJS, TEN OU HSS". A presente invenção provê um método de predizer o risco de um paciente desenvolver reações adversas a droga, particularmente a síndrome Stevens-Johnson (SJS), necrólise epidérmica tóxica (TEN) ou síndrome de hipersensibilidade a droga (HSS). Descobriu-se que um alelo HLA-13, HLA-B* 1502 associado com SJS/TEN, que são induzidos por uma variedade de drogas. A correlação com HLA-B* 1502 é muitíssimo significativa para SJS/TEN induzidos por carbamazepina, em que todos os pacientes testados têm o alelo HLA-13*1502. Além disso, outro alelo HLA13, HLA-B*5801, é particularmente associado com SJS/TEN ou HSS induzidos por alopurinol. Reações cutâneas mais suaves, tais como erupção maculopapular, eritema multiforme (EM), urticária e erupção por droga fixa, são particularmente associadas com um terceiro alelo, HLA-13*4601. Para qualquer um dos alelos, os marcadores genéticos (p. ex., marcadores HLA, microssatélite ou marcadores de polimorfismo de nucleotídeo simples), localizados entre a região DRB1 e HLA-A do haplótipo HLA-B específico, podem também ser usados para o teste.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/705,245 US7470513B2 (en) | 2003-11-10 | 2003-11-10 | Risk assessment for adverse drug reactions |
PCT/US2004/019435 WO2005047544A1 (en) | 2003-11-10 | 2004-06-18 | Risk assessment for adverse drug reactions |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0416355A true BRPI0416355A (pt) | 2007-03-13 |
Family
ID=34552314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0416355-9A BRPI0416355A (pt) | 2003-11-10 | 2004-06-18 | métodos para avaliar o risco de um paciente desenvolver uma reação adversa a droga, para desenvolver uma terapia para uma reação adversa induzida por uma droga, para avaliar o risco de um paciente desenvolver sjs, ten ou hss, e para identificar uma droga que induz sjs, ten ou hss |
Country Status (16)
Country | Link |
---|---|
US (5) | US7470513B2 (pt) |
EP (1) | EP1697539B1 (pt) |
CN (1) | CN1902328B (pt) |
AT (1) | ATE476524T1 (pt) |
AU (1) | AU2004289951B2 (pt) |
BR (1) | BRPI0416355A (pt) |
CA (1) | CA2544369C (pt) |
CY (1) | CY1110760T1 (pt) |
DE (1) | DE602004028508D1 (pt) |
DK (1) | DK1697539T3 (pt) |
ES (1) | ES2347150T3 (pt) |
PL (1) | PL1697539T3 (pt) |
PT (1) | PT1697539E (pt) |
SI (1) | SI1697539T1 (pt) |
TW (1) | TWI287580B (pt) |
WO (1) | WO2005047544A1 (pt) |
Families Citing this family (42)
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US7127355B2 (en) * | 2004-03-05 | 2006-10-24 | Perlegen Sciences, Inc. | Methods for genetic analysis |
US20090087854A1 (en) * | 2007-09-27 | 2009-04-02 | Perlegen Sciences, Inc. | Methods for genetic analysis |
US20060166224A1 (en) * | 2005-01-24 | 2006-07-27 | Norviel Vernon A | Associations using genotypes and phenotypes |
US7452689B2 (en) * | 2005-05-20 | 2008-11-18 | Mayo Foundation For Medical Education And Research | Method for rapid determination of thiopurine methyltransferase activity |
WO2007134235A2 (en) * | 2006-05-11 | 2007-11-22 | Academia Sinica | Hla alleles associated with adverse drug reactions and methods for detecting such |
EP2344892B8 (en) * | 2008-10-01 | 2014-11-12 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Glucuronidated acetaminophen as a marker of hepatic disorders |
CN102108382A (zh) * | 2009-12-23 | 2011-06-29 | 上海主健生物工程有限公司 | 卡马西平致皮肤严重不良反应遗传检测 |
US8927462B2 (en) | 2010-04-12 | 2015-01-06 | Academia Sinica | Method for identifying HLA complexes associated with adverse drug reactions |
CN103827312B (zh) * | 2011-06-23 | 2016-06-15 | 长庚医疗财团法人基隆长庚纪念医院 | 评估抗癫痫药物苯妥英引发药物不良反应风险的方法 |
CN105039579B (zh) * | 2011-06-23 | 2018-10-02 | 长庚医疗财团法人基隆长庚纪念医院 | 用hla等位基因评估抗癫痫药物苯妥英引发药物过敏反应的方法 |
CN102296109A (zh) * | 2011-06-30 | 2011-12-28 | 北京思尔成生物技术有限公司 | HLA-B*1502基因的SYBR Green I检测方法及其专用引物与试剂盒 |
TW201307846A (zh) * | 2011-08-02 | 2013-02-16 | Chang Gung Medical Foundation Chang Gung Memorial Hospital at Keelung | 評估抗癲癇藥物引發不良反應或過敏反應風險(adr)的方法 |
US10370409B2 (en) | 2011-10-25 | 2019-08-06 | The Scripps Research Institute | Synthesis of libraries of peptide tertiary amides |
US20150225788A1 (en) * | 2011-12-12 | 2015-08-13 | Wen-Hung Chung | Risk assessment for phenytoin-induced adverse drug reactions |
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JP2015107095A (ja) * | 2013-03-14 | 2015-06-11 | 凸版印刷株式会社 | 眼合併症を伴う重症薬疹の発症リスクの評価方法 |
CN104818316B (zh) * | 2013-11-28 | 2018-09-21 | 复旦大学 | 用于筛查柳氮磺胺吡啶所致皮肤药物不良反应的人类白细胞抗原基因检测试剂盒 |
CN103646185A (zh) * | 2013-12-25 | 2014-03-19 | 顾德国 | 一种药品不良反应报告质量评估系统及方法 |
CN104017898B (zh) * | 2014-06-25 | 2016-04-27 | 上海荻硕贝肯生物科技有限公司 | 快速检测hla-b*5801等位基因的引物、试剂盒及方法 |
KR101591603B1 (ko) * | 2014-10-16 | 2016-02-04 | 연세대학교 산학협력단 | 약물유해반응 예측에 관한 정보 제공 방법 |
CN104450914A (zh) * | 2014-12-10 | 2015-03-25 | 苏州旷远生物分子技术有限公司 | 用于检测人hla-b*1502基因的引物、探针、荧光pcr试剂盒和方法 |
US9927443B2 (en) | 2015-04-10 | 2018-03-27 | Conquerab Inc. | Risk assessment for therapeutic drugs |
US9932638B2 (en) | 2015-06-29 | 2018-04-03 | Millennium Health, LLC | Single nucleotide polymorphism in HLA-B*15:02 and use thereof |
US9903866B2 (en) | 2016-04-05 | 2018-02-27 | Conquerab Inc. | Portable devices for detection of antibodies against therapeutic drugs |
JP2019522466A (ja) | 2016-05-18 | 2019-08-15 | アルバート アインシュタイン カレッジ オブ メディシン,インコーポレイティド | 変異pd−l1ポリペプチド、t細胞調節多量体ポリペプチド、及びそれらの使用方法 |
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US11289178B2 (en) | 2017-04-21 | 2022-03-29 | International Business Machines Corporation | Identifying chemical substructures associated with adverse drug reactions |
SG11202003391XA (en) * | 2017-10-27 | 2020-05-28 | Chang Gung Memorial Hospital Linkou | Method for assessing the risk of cutaneous adverse drug reactions induced by anti-epileptic drug lamotrigine, detection reagent thereof and use thereof |
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CN108342457B (zh) * | 2018-04-01 | 2021-12-07 | 广东辉锦创兴生物医学科技有限公司 | Hla-b5801等位基因的检测试剂盒及其应用 |
CN108866007A (zh) * | 2018-04-26 | 2018-11-23 | 厦门敖依生物科技有限公司 | 一种检测hla-b*5801的单克隆抗体及其制备方法与应用 |
US20220177968A1 (en) * | 2019-03-12 | 2022-06-09 | Chang Gung Memorial Hospital, Linkou | Methods for detecting or reducing the incidence of adverse drug reactions |
TWI804620B (zh) * | 2019-05-06 | 2023-06-11 | 長庚醫療財團法人林口長庚紀念醫院 | 評估疾病調節抗風濕藥物引發嚴重皮膚藥物不良反應風險的方法、其檢測套組及其用途 |
CA3137521A1 (en) * | 2019-05-06 | 2020-11-12 | Chang Gung Memorial Hospital, Linkou | Methods for assessing the risk of developing severe cutaneous adverse drug reactions induced by disease-modifying antirheumatic drugs, detection kit thereof and uses thereof |
US11763946B2 (en) * | 2020-02-27 | 2023-09-19 | Optum, Inc. | Graph-based predictive inference |
CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5550039A (en) * | 1995-03-07 | 1996-08-27 | Hoffmann-La Roche Inc. | Oligonucleotide primers for HLA class I B locus DNA typing |
US6583139B1 (en) * | 1997-07-31 | 2003-06-24 | Eugene D. Thorsett | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US7470513B2 (en) * | 2003-11-10 | 2008-12-30 | Academia Sinica | Risk assessment for adverse drug reactions |
-
2003
- 2003-11-10 US US10/705,245 patent/US7470513B2/en active Active
-
2004
- 2004-06-18 CA CA2544369A patent/CA2544369C/en not_active Expired - Lifetime
- 2004-06-18 DE DE602004028508T patent/DE602004028508D1/de not_active Expired - Lifetime
- 2004-06-18 ES ES04776718T patent/ES2347150T3/es not_active Expired - Lifetime
- 2004-06-18 PT PT04776718T patent/PT1697539E/pt unknown
- 2004-06-18 WO PCT/US2004/019435 patent/WO2005047544A1/en active Application Filing
- 2004-06-18 EP EP04776718A patent/EP1697539B1/en not_active Expired - Lifetime
- 2004-06-18 AT AT04776718T patent/ATE476524T1/de active
- 2004-06-18 PL PL04776718T patent/PL1697539T3/pl unknown
- 2004-06-18 AU AU2004289951A patent/AU2004289951B2/en not_active Expired
- 2004-06-18 BR BRPI0416355-9A patent/BRPI0416355A/pt not_active IP Right Cessation
- 2004-06-18 SI SI200431510T patent/SI1697539T1/sl unknown
- 2004-06-18 CN CN2004800401779A patent/CN1902328B/zh not_active Expired - Lifetime
- 2004-06-18 DK DK04776718.1T patent/DK1697539T3/da active
- 2004-06-24 TW TW093118331A patent/TWI287580B/zh active
-
2008
- 2008-05-20 US US12/123,700 patent/US7964351B2/en active Active
- 2008-10-29 US US12/260,521 patent/US8012686B2/en active Active
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2010
- 2010-08-25 CY CY20101100782T patent/CY1110760T1/el unknown
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2011
- 2011-08-17 US US13/211,614 patent/US20120077192A1/en not_active Abandoned
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2013
- 2013-08-14 US US13/966,996 patent/US9562268B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1697539A1 (en) | 2006-09-06 |
EP1697539B1 (en) | 2010-08-04 |
ATE476524T1 (de) | 2010-08-15 |
AU2004289951A1 (en) | 2005-05-26 |
CY1110760T1 (el) | 2015-06-10 |
CA2544369A1 (en) | 2005-05-26 |
ES2347150T3 (es) | 2010-10-26 |
CA2544369C (en) | 2014-08-05 |
US20130330724A1 (en) | 2013-12-12 |
US7964351B2 (en) | 2011-06-21 |
PT1697539E (pt) | 2010-10-04 |
CN1902328A (zh) | 2007-01-24 |
SI1697539T1 (sl) | 2010-11-30 |
US8012686B2 (en) | 2011-09-06 |
US7470513B2 (en) | 2008-12-30 |
PL1697539T3 (pl) | 2010-12-31 |
AU2004289951B2 (en) | 2009-10-22 |
TW200525038A (en) | 2005-08-01 |
DE602004028508D1 (de) | 2010-09-16 |
US20090053727A1 (en) | 2009-02-26 |
DK1697539T3 (da) | 2010-11-22 |
TWI287580B (en) | 2007-10-01 |
WO2005047544A1 (en) | 2005-05-26 |
US20120077192A1 (en) | 2012-03-29 |
US9562268B2 (en) | 2017-02-07 |
CN1902328B (zh) | 2010-10-20 |
US20050100926A1 (en) | 2005-05-12 |
US20080227109A1 (en) | 2008-09-18 |
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