BRPI0415838A - compostos de 2- (e)-2- (fenil) etenil-4- (arilalcoxi)-oxazola ou-tiazola como inibidores de her-2 tirosina quinases e seu uso no tratamento de cáncer - Google Patents

compostos de 2- (e)-2- (fenil) etenil-4- (arilalcoxi)-oxazola ou-tiazola como inibidores de her-2 tirosina quinases e seu uso no tratamento de cáncer

Info

Publication number
BRPI0415838A
BRPI0415838A BRPI0415838-5A BRPI0415838A BRPI0415838A BR PI0415838 A BRPI0415838 A BR PI0415838A BR PI0415838 A BRPI0415838 A BR PI0415838A BR PI0415838 A BRPI0415838 A BR PI0415838A
Authority
BR
Brazil
Prior art keywords
cancer
ethenyl
oxazole
phenyl
compounds
Prior art date
Application number
BRPI0415838-5A
Other languages
English (en)
Inventor
Brigit Bossenmaier
Walter-Gunar Friebe
Ulrike Reiff
Matthias Rueth
Edgar Voss
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0415838A publication Critical patent/BRPI0415838A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS DE 2-(E)-2- (FENIL) ETENIL-4- (ARILALCOXI)-OXAZOLA OU-TIAZOLA COMO INIBIDORES DE HER-2 TIROSINA QUINASES E SEU USO NO TRATAMENTO DE CáNCER". São objetos da presente invenção os compostos de fórmula (I), seus sais aceitáveis do ponto de vista farmacêutico, formas enancioméricas dos mesmos, diastereoisómeros e racematos, a preparação dos compostos acima mencionados, medicamentos contendo os mesmos e sua fabricação, bem como o uso dos compostos mencionados no controle ou prevenção de doenças tais como câncer.
BRPI0415838-5A 2003-10-24 2004-10-22 compostos de 2- (e)-2- (fenil) etenil-4- (arilalcoxi)-oxazola ou-tiazola como inibidores de her-2 tirosina quinases e seu uso no tratamento de cáncer BRPI0415838A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP03024399 2003-10-24
EP03024694 2003-10-28
EP03025948 2003-11-13
PCT/EP2004/011943 WO2005040158A1 (en) 2003-10-24 2004-10-22 1-′(e)-2-(phenyl) ethenyl-4-(arylalkoxy)-oxazole or - thiazole compounds as her-2 tyrosine kinases inhibitors and their use in the treatment of cancer

Publications (1)

Publication Number Publication Date
BRPI0415838A true BRPI0415838A (pt) 2007-01-02

Family

ID=34527387

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415838-5A BRPI0415838A (pt) 2003-10-24 2004-10-22 compostos de 2- (e)-2- (fenil) etenil-4- (arilalcoxi)-oxazola ou-tiazola como inibidores de her-2 tirosina quinases e seu uso no tratamento de cáncer

Country Status (9)

Country Link
US (1) US7259262B2 (pt)
EP (1) EP1680417A1 (pt)
JP (1) JP2007509102A (pt)
KR (1) KR100797434B1 (pt)
AU (1) AU2004283874A1 (pt)
BR (1) BRPI0415838A (pt)
CA (1) CA2539720A1 (pt)
MX (1) MXPA06004404A (pt)
WO (1) WO2005040158A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200531688A (en) * 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
BRPI0513777A (pt) * 2004-07-26 2008-05-13 Lilly Co Eli composto ou um sal do mesmo, composição farmacêutica, e, uso de um composto ou de um sal do mesmo
JP2014505052A (ja) * 2011-01-06 2014-02-27 ベータ ファルマ カナダ インコーポレーテッド 癌の治療および予防用の新規なウレア
US10246449B2 (en) * 2015-12-21 2019-04-02 Council Of Scientific & Industrial Research 1,2,3 triazole-thiazole compounds, process for preparation and use thereof
CN117820251B (zh) * 2024-03-01 2024-05-03 南京桦冠生物技术有限公司 双α-酮酸酰胺类化合物及其组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3461697A (en) 1996-07-19 1998-02-10 Takeda Chemical Industries Ltd. Heterocyclic compounds, their production and use
PE20011178A1 (es) 2000-04-07 2001-11-19 Takeda Chemical Industries Ltd Compuestos heterociclicos y su produccion
CA2431322A1 (en) 2000-12-11 2002-06-20 Eiji Nara Medicinal compositions having improved absorbability
WO2003031442A1 (fr) 2001-10-05 2003-04-17 Takeda Chemical Industries, Ltd. Composes heterocycliques, derives oxazole, procede permettant de les presenter et leur utilisation
AU2003203170A1 (en) 2002-01-17 2003-07-30 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
TW200612914A (en) * 2004-03-05 2006-05-01 Hoffmann La Roche Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents

Also Published As

Publication number Publication date
US20050124670A1 (en) 2005-06-09
AU2004283874A1 (en) 2005-05-06
JP2007509102A (ja) 2007-04-12
KR20060057009A (ko) 2006-05-25
KR100797434B1 (ko) 2008-01-23
MXPA06004404A (es) 2006-06-14
EP1680417A1 (en) 2006-07-19
US7259262B2 (en) 2007-08-21
WO2005040158A1 (en) 2005-05-06
CA2539720A1 (en) 2005-05-06

Similar Documents

Publication Publication Date Title
BRPI0519567A2 (pt) heterociclos tricÍclicos, sua fabricaÇço e uso como agentes farmacÊuticos
BRPI0515885A (pt) derivados de ftalazinona, sua preparação e uso como agentes farmacêuticos
NO20053775L (no) Diazepinoindol derivater som kinaseinhibitorer.
BRPI0508485A (pt) compostos de pentafluorsulfanila, sua fabricação e uso como agentes farmacêuticos
BRPI0414548B8 (pt) derivados de 2-piridona como inibidores de elastase de neutrófilo e seu uso
ATE411022T1 (de) Pyridylpyrrol-derivate als wirksame kinase-hemmer
BRPI0407618A (pt) derivados de tiazole amino substituidos com cicloalquilo contendo n e composições farmacêuticas para inibição da proliferação celular e métodos para a sua utilização
BRPI0606313A2 (pt) derivados de 4-(1h-indol-3-il)-pirimidin-2-ilamina, processo para sua preparação e seu uso em terapia
BRPI0414570A (pt) derivados de 2-piridona como inibidores de elastase de neutrófilo e seu uso
DK1636236T3 (da) Pyrazolo-quinazolin-derivater, en fremgangsmåde til fremstilling deraf, og deres anvendelse som kinase-inhibitorer
CY1114037T1 (el) 2-(μορφολιν-4-υλ) πυριμιδινες ως αναστολεις της κινασης της φωσφατιδυλο-ινοσιτολης (ρι) 3 και η χρηση τους στη θεραπεια του καρκινου
UY27714A1 (es) 2 - heteroaril - pirimidinas inhibidoras de cdk, su preparación y su uso como medicamentos.
WO2007007919A3 (en) Heterocyclic janus kinase 3 inhibitors
NO20092737L (no) Substituerte pyrazolo-kinazolinderivater, fremgangsmate for deres fremstilling og deres anvendelse som kinase-inhibitorer
MX2009002010A (es) Derivados de heteroarilo como inhibidores de la proteina cinasa.
ECSP066718A (es) Derivados de pirazolo[1,5-a]pirimidin-7-il-amina para usar en el tratamiento de enfermedades dependientes de la proteina quinasa
ATE327225T1 (de) Neue verwendung von benzothiazolderivaten
ECSP055525A (es) Inhibidores de cinasas de tirosina
BR0209774A (pt) Pirimidinas inibidoras de cdk, sua preparação e aplicação como medicamento
CY1109681T1 (el) Υποκατεστημενα παραγωγα κιναζολινης ως αναστολεις των κινασων aurora
WO2006066914A3 (en) Carbamate substituted imidazo- and pyrrolo-pyridines as protein kinase inhibitors
BR0209518A (pt) Novos derivados arilheteroalquilamina
BR0314797A (pt) Derivados da pirimidineamida e o uso dos mesmos
ECSP099767A (es) Derivados de n' - (fenil) -n- (morfolin-4-il-piridin-2-il) -pirimidina-2, 4-diamina como inhibidores de quinasas ephb4 para el tratamiento de afecciones proliferativas
BRPI0111142B8 (pt) utilização de derivados de biguanida ou sais farmaceuticamente aceitáveis dos mesmos para fabricação de medicamento tendo um efeito cicatrizante

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.