BRPI0414933A - derivativos de imidazopiridina como inibidores de óxido nìtrico sintase induzìvel - Google Patents

derivativos de imidazopiridina como inibidores de óxido nìtrico sintase induzìvel

Info

Publication number
BRPI0414933A
BRPI0414933A BRPI0414933-5A BRPI0414933A BRPI0414933A BR PI0414933 A BRPI0414933 A BR PI0414933A BR PI0414933 A BRPI0414933 A BR PI0414933A BR PI0414933 A BRPI0414933 A BR PI0414933A
Authority
BR
Brazil
Prior art keywords
inducibly
nitric oxide
oxide synthase
synthase inhibitors
inducible nitric
Prior art date
Application number
BRPI0414933-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Wolf-Ruediger Ulrich
Thomas Fuchss
Thomas Martin
Rainer Boer
Andreas Strub
Manfrid Eltze
Martin Lehner
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of BRPI0414933A publication Critical patent/BRPI0414933A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
BRPI0414933-5A 2003-10-01 2004-09-30 derivativos de imidazopiridina como inibidores de óxido nìtrico sintase induzìvel BRPI0414933A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03022046 2003-10-01
PCT/EP2004/052377 WO2005030770A1 (en) 2003-10-01 2004-09-30 Imidazopyridine-derivatives as inducible no-synthase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0414933A true BRPI0414933A (pt) 2006-11-07

Family

ID=34384570

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414933-5A BRPI0414933A (pt) 2003-10-01 2004-09-30 derivativos de imidazopiridina como inibidores de óxido nìtrico sintase induzìvel

Country Status (19)

Country Link
US (3) US7279488B2 (enExample)
EP (1) EP1670796B1 (enExample)
JP (1) JP2007507466A (enExample)
KR (1) KR20060092297A (enExample)
CN (1) CN100422182C (enExample)
AT (1) ATE399168T1 (enExample)
AU (1) AU2004276014A1 (enExample)
BR (1) BRPI0414933A (enExample)
CA (1) CA2540243A1 (enExample)
DE (1) DE602004014628D1 (enExample)
EA (1) EA200600607A1 (enExample)
ES (1) ES2308260T3 (enExample)
IL (1) IL173810A0 (enExample)
MX (1) MXPA06003351A (enExample)
NO (1) NO20061317L (enExample)
NZ (1) NZ546435A (enExample)
RS (1) RS20060200A (enExample)
WO (1) WO2005030770A1 (enExample)
ZA (1) ZA200601553B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004014523D1 (de) 2003-10-01 2008-07-31 Nycomed Gmbh Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase
JP2007507464A (ja) 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のアミノピリジン誘導体
EA010261B1 (ru) 2003-10-01 2008-06-30 Алтана Фарма Аг Производные имидазопиридина как ингибиторы индуцируемой no - синтазы
NZ546435A (en) * 2003-10-01 2009-08-28 Altana Pharma Ag Imidazopyridine-derivatives as inducible NO-synthase inhibitors
EA012280B1 (ru) 2004-05-28 2009-08-28 4Сц Аг Новые производные тетрагидропиридотиофена
WO2005120642A2 (en) 2004-06-11 2005-12-22 Altana Pharma Ag Tetrahydropyridothiophenes for treating hyperproliferative disorders
CA2596202A1 (en) 2005-02-09 2006-08-17 Altana Pharma Ag Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
WO2006084904A1 (en) 2005-02-11 2006-08-17 Nycomed Gmbh Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer
JP2008542243A (ja) 2005-05-25 2008-11-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のテトラヒドロピリドチオフェン
US7714136B2 (en) 2005-05-25 2010-05-11 4Sc Ag Tetrahydropyridothiophenes
AR057525A1 (es) * 2005-10-03 2007-12-05 Astrazeneca Ab Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion
UY29825A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones
WO2007045622A1 (en) * 2005-10-18 2007-04-26 Nycomed Gmbh Oxazolo [4 , 5-b] pyridine compounds as nitric oxide synthase inhibitors
CA2632027A1 (en) 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
KR102359212B1 (ko) 2015-03-16 2022-02-08 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
AU650953B2 (en) * 1991-03-21 1994-07-07 Novartis Ag Inhaler
SE512835C2 (sv) 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
AUPP873799A0 (en) * 1999-02-17 1999-03-11 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds
CN1307176C (zh) 2002-03-27 2007-03-28 奥坦纳医药公司 新的烷氧基吡啶衍生物
DE602004014523D1 (de) 2003-10-01 2008-07-31 Nycomed Gmbh Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase
NZ546435A (en) * 2003-10-01 2009-08-28 Altana Pharma Ag Imidazopyridine-derivatives as inducible NO-synthase inhibitors
EA010261B1 (ru) * 2003-10-01 2008-06-30 Алтана Фарма Аг Производные имидазопиридина как ингибиторы индуцируемой no - синтазы
EA200600609A1 (ru) 2003-10-01 2006-10-27 Алтана Фарма Аг Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
JP2007507464A (ja) 2003-10-01 2007-03-29 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のアミノピリジン誘導体

Also Published As

Publication number Publication date
DE602004014628D1 (de) 2008-08-07
MXPA06003351A (es) 2006-06-08
US7709488B2 (en) 2010-05-04
CN1856495A (zh) 2006-11-01
US20080021039A1 (en) 2008-01-24
CN100422182C (zh) 2008-10-01
NZ546435A (en) 2009-08-28
KR20060092297A (ko) 2006-08-22
WO2005030770A1 (en) 2005-04-07
US20100216790A1 (en) 2010-08-26
IL173810A0 (en) 2006-07-05
ATE399168T1 (de) 2008-07-15
EA200600607A1 (ru) 2006-10-27
US7279488B2 (en) 2007-10-09
NO20061317L (no) 2006-03-23
US20060293302A1 (en) 2006-12-28
ZA200601553B (en) 2007-04-25
EP1670796B1 (en) 2008-06-25
AU2004276014A1 (en) 2005-04-07
JP2007507466A (ja) 2007-03-29
CA2540243A1 (en) 2005-04-07
RS20060200A (sr) 2008-08-07
ES2308260T3 (es) 2008-12-01
HK1096549A1 (zh) 2007-06-01
EP1670796A1 (en) 2006-06-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.