BRPI0414803A - derivados de ácido 4-(1-benzofuran-3-il-metilidenoaminoxi-propóxi)-benz óico e compostos relacionados como inibidores de pai-1 para o tratamento de dano do sistema fibrinolìtico e de trombose - Google Patents
derivados de ácido 4-(1-benzofuran-3-il-metilidenoaminoxi-propóxi)-benz óico e compostos relacionados como inibidores de pai-1 para o tratamento de dano do sistema fibrinolìtico e de tromboseInfo
- Publication number
- BRPI0414803A BRPI0414803A BRPI0414803-7A BRPI0414803A BRPI0414803A BR PI0414803 A BRPI0414803 A BR PI0414803A BR PI0414803 A BRPI0414803 A BR PI0414803A BR PI0414803 A BRPI0414803 A BR PI0414803A
- Authority
- BR
- Brazil
- Prior art keywords
- aryl
- heteroaryl
- alkyl
- pai
- thrombosis
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
"DERIVADOS DE áCIDO 4-(1-BENZOFURAN-3-IL-METILIDENOAMINOXI-PROPóXI)-BENZ óICO E COMPOSTOS RELACIONADOS COMO INIBIDORES DE PAI-1 PARA O TRATAMENTO DE DANO DO SISTEMA FIBRINOLìTICO E DE TROMBOSE". A presente invenção refere-se a oximas de benzofurila de fórmula (I) ou um sal farmaceuticamente aceitável ou forma de éster deste, em que R~ 1~ é uma ligação direta a A, C~ 1~-C~ 4~ alquileno, ou -O-C~ 1~-C~ 4~ alquileno; R~ 2~ e R~ 3~ são, independentemente, hidrogênio, halogênio, C~ 1~-C~ 4~ alquila, C~ 1~-C~ 3~ perfluoroalquila, -O-C~ 1~-C~ 3~ perfluoroalquila, C~ 1~-C~ 3~ alcóxi, -OH, -NH~ 2~, -NO~ 2~, arila, heteroarila, -O(CH~ 2~)~ p~-arila, -O(CH~ 2~)~ p~-heteroarila, -NH(CH~ 2~)~ p~-arila, -NH(CH~ 2~)~ p~heteroarila, -NH(CO)-arila, -NH(CO)-heteroarila, -O(CO)-arila, -O(CO)heteroarila, -NH(CO)-CH=CH-arila, ou -NH(CO)-CH=CH-heteroarila; p é um número inteiro de 0 a 6; R~ 4~ é hidrogênio, C~ 1~-C~ 8~ alquila, ou C~ 3~-C~ 6~ cicloalquila; A é -COOH ou uma mímica de ácido; X é C~ 1~-C~ 8~ alquileno, C~ 3~-C~ 6~ cicloalquileno, -(CH~ 2~)~ m~O-, ou -(CH~ 2~)~ m~NH-; m é um número inteiro de 1 a 6; e R~ 5~ é hidrogênio, C~ 1~-C~ 8~ alquila, C~ 3~-C~ 6~ cicloalquila, -CH~ 2~-C~ 3~-C~ 6~ cicloalquila, heteroarila, -CH~ 2~-heteroarila, arila, ou benzila; R~ 6~ e R~ 7~, são, independentemente, hidrogênio, halogênio, C~ 1~-C~ 6~ alquila, C~ 1~-C~ 6~ perfluoroalquila, -O-C~ 1~-C~ 6~ perfluoroalquila, C~ 1~-C~ 6~ alcóxi, -OH, -NH~ 2~, -NO~ 2~, -O(CH~ 2~)~ n~-arila, -O(CH~ 2~)~ n~-heteroarila, arila, ou heteroarila; e n é um número inteiro de 0 a 6, onde os grupos de alquila, cicloalquila, arila e heteroarila são cada opcionalmente substituído por um ou mais substituintes. Os presentes compostos são inibidores de PAI-1 para o tratamento por exemplo de enfraquecimento do sistema fibrinolítico, trombose ou doenças cardiovasculares.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50580103P | 2003-09-25 | 2003-09-25 | |
US10/947,930 US20050215626A1 (en) | 2003-09-25 | 2004-09-23 | Substituted benzofuran oximes |
PCT/US2004/031361 WO2005030199A1 (en) | 2003-09-25 | 2004-09-24 | 4-(1-benzofuran-3-yl-methylideneaminoxy.propoxy))-benzoic acid derivatives and related compounds as pai-1 inhibitors for the treatment of impairment of the fibrinolytic system and of thrombosis |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414803A true BRPI0414803A (pt) | 2006-11-14 |
Family
ID=34396267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414803-7A BRPI0414803A (pt) | 2003-09-25 | 2004-09-24 | derivados de ácido 4-(1-benzofuran-3-il-metilidenoaminoxi-propóxi)-benz óico e compostos relacionados como inibidores de pai-1 para o tratamento de dano do sistema fibrinolìtico e de trombose |
Country Status (8)
Country | Link |
---|---|
US (1) | US20050215626A1 (pt) |
EP (1) | EP1667676A1 (pt) |
JP (1) | JP2007506758A (pt) |
AU (1) | AU2004275807A1 (pt) |
BR (1) | BRPI0414803A (pt) |
CA (1) | CA2538574A1 (pt) |
MX (1) | MXPA06003250A (pt) |
WO (1) | WO2005030199A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
WO2003000253A1 (en) * | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
ATE411288T1 (de) * | 2002-12-10 | 2008-10-15 | Wyeth Corp | Aryl-, aryloxy- und alkyloxysubstituierte 1h- indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
WO2004052855A2 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
US7348351B2 (en) * | 2002-12-10 | 2008-03-25 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1H-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
CN101044127A (zh) * | 2004-08-23 | 2007-09-26 | 惠氏公司 | 用作纤溶酶原激活剂抑制剂-1的噻唑基-萘基酸 |
BRPI0514544A (pt) * | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de oxazol-naftila como moduladores de inibidor tipo-1 de ativador de plasminogênio (pai-1) |
US7186749B2 (en) * | 2004-08-23 | 2007-03-06 | Wyeth | Pyrrolo-naphthyl acids and methods for using them |
JP2009504762A (ja) * | 2005-08-17 | 2009-02-05 | ワイス | 置換インドール類およびそれらの使用方法 |
PE20071017A1 (es) * | 2006-02-27 | 2007-11-12 | Wyeth Corp | Derivados de acido indol sustituido como inhibidores del activador de plasminogeno tipo 1 (pai-1) |
US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3147276A1 (de) * | 1981-11-28 | 1983-06-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole |
DE3413363A1 (de) * | 1984-04-09 | 1985-10-17 | Merz + Co GmbH & Co, 6000 Frankfurt | Benzofuran-2-yl-ethyl-imidazolderivate, verfahren zu ihrer herstellung und pharmazeutische mittel |
DE3531658A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel |
AU4639089A (en) * | 1988-12-29 | 1990-08-01 | Ciba-Geigy Ag | Methyl esters of aldimino- or ketimino-oxy-ortho-tolylacrylic acid, manufacturing process and fungicides containing them |
NZ242290A (en) * | 1991-04-15 | 1994-12-22 | Zeneca Ltd | Pyridyl and pyrimidinyl substituted oxime-o-benzyl ether derivatives; preparatory processes, fungicidal compositions and an intermediate |
DE4213149A1 (de) * | 1992-04-22 | 1993-10-28 | Hoechst Ag | Akarizide, insektizide und nematizide substituierte (Hetero)-Aryl-Alkyl-ketonoxim-O-ether, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
EP0608862A1 (en) * | 1993-01-27 | 1994-08-03 | Lucky Ltd. | Novel 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl) oxybenzoic acid ester derivatives, processes for their production an a method for their application as herbicides |
US5599663A (en) * | 1993-08-27 | 1997-02-04 | Brighan & Women's Hospital | Angiotensin IV and analogs as regulators of fibrinolysis |
BR9506648A (pt) * | 1994-01-27 | 1997-09-02 | Ciba Geigy Ag | Processo para a preparação de derivados de éster arilacético via reação de acoplameno cruzada catalisado por paládio |
WO1996036615A1 (en) * | 1995-05-16 | 1996-11-21 | E.I. Du Pont De Nemours And Company | Fungicidal cyclic amides |
ATE239004T1 (de) * | 1996-05-20 | 2003-05-15 | Darwin Discovery Ltd | Benzofuran carboxamide und ihre therapeutische anwendung |
EP1125931A1 (en) * | 2000-02-17 | 2001-08-22 | Hunan Research Institute of Chemical Industry | Biocidal alkyl-substituted-(hetero)aryl-ketoxime-O-ethers and the production method thereof |
WO2001064646A2 (en) * | 2000-03-01 | 2001-09-07 | Tularik Inc. | Hydrazones and analogs as cholesterol lowering agents |
-
2004
- 2004-09-23 US US10/947,930 patent/US20050215626A1/en not_active Abandoned
- 2004-09-24 EP EP04784965A patent/EP1667676A1/en not_active Withdrawn
- 2004-09-24 CA CA002538574A patent/CA2538574A1/en not_active Abandoned
- 2004-09-24 WO PCT/US2004/031361 patent/WO2005030199A1/en active Application Filing
- 2004-09-24 AU AU2004275807A patent/AU2004275807A1/en not_active Abandoned
- 2004-09-24 BR BRPI0414803-7A patent/BRPI0414803A/pt not_active IP Right Cessation
- 2004-09-24 JP JP2006528202A patent/JP2007506758A/ja active Pending
- 2004-09-24 MX MXPA06003250A patent/MXPA06003250A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2007506758A (ja) | 2007-03-22 |
EP1667676A1 (en) | 2006-06-14 |
CA2538574A1 (en) | 2005-04-07 |
WO2005030199A1 (en) | 2005-04-07 |
MXPA06003250A (es) | 2006-06-08 |
US20050215626A1 (en) | 2005-09-29 |
AU2004275807A1 (en) | 2005-04-07 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |