BRPI0410091A - vacina para vìrus influenza eqüina, e, método para induzir uma resposta imune contra vìrus influenza eqüina - Google Patents
vacina para vìrus influenza eqüina, e, método para induzir uma resposta imune contra vìrus influenza eqüinaInfo
- Publication number
- BRPI0410091A BRPI0410091A BRPI0410091-3A BRPI0410091A BRPI0410091A BR PI0410091 A BRPI0410091 A BR PI0410091A BR PI0410091 A BRPI0410091 A BR PI0410091A BR PI0410091 A BRPI0410091 A BR PI0410091A
- Authority
- BR
- Brazil
- Prior art keywords
- vaccine
- influenza virus
- virus
- equine influenza
- dna
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
"VACINA PARA VìRUS INFLUENZA EQüINA, E, MéTODO PARA INDUZIR UMA RESPOSTA IMUNE CONTRA VìRUS INFLUENZA EQüINA". A invenção refere-se a uma vacina de DNA que expressa o gene de hemaglutinina (HA1) do virus influenza eqüina-2. Manipulando-se um códon de interrupção no HA1, assegura-se a expressão de HA1. A encapsulação da vacina de DNA em lipossoma e a inoculação intranasal, é suficiente para elicitar imunidade protetora a uma dosagem significativamente menor se comparada com uma vacina de DNA que expressa o gene HA de comprimento total. Dosagem menor reduz o risco de indução de anticorpos anti-DNA. Inoculação intranasal diretamente nas células epiteliais respiratórias reduz o risco de integração de DNA. A vacina de acordo com a invenção é vantajosa relativamente a vacinas correntes inativadas ou vivas atenuadas, porque a atualização da vacina requer apenas a substituição da seqüência codificadora com o novo vírus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47084303P | 2003-05-15 | 2003-05-15 | |
PCT/US2004/011998 WO2005014778A2 (en) | 2003-05-15 | 2004-04-16 | Dna vaccine expressing ha1 of equine-2 influenza virus |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0410091A true BRPI0410091A (pt) | 2006-06-06 |
Family
ID=34135039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0410091-3A BRPI0410091A (pt) | 2003-05-15 | 2004-04-16 | vacina para vìrus influenza eqüina, e, método para induzir uma resposta imune contra vìrus influenza eqüina |
Country Status (12)
Country | Link |
---|---|
US (1) | US7244435B2 (pt) |
EP (1) | EP1623015A4 (pt) |
JP (1) | JP2007525456A (pt) |
KR (1) | KR20060035602A (pt) |
CN (1) | CN1925870A (pt) |
AU (1) | AU2004263816A1 (pt) |
BR (1) | BRPI0410091A (pt) |
CA (1) | CA2523676A1 (pt) |
MX (1) | MXPA05012199A (pt) |
NZ (1) | NZ543196A (pt) |
WO (1) | WO2005014778A2 (pt) |
ZA (1) | ZA200509187B (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
CA2543257C (en) | 2003-10-24 | 2013-12-31 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
CA2606429A1 (en) * | 2005-04-21 | 2006-11-02 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
KR101484305B1 (ko) * | 2006-03-10 | 2015-01-19 | 위스콘신 얼럼나이 리서어치 화운데이션 | H3 말 인플루엔자 a 바이러스 |
US7682619B2 (en) * | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
CN101502649B (zh) * | 2008-06-23 | 2011-11-30 | 深圳职业技术学院 | 一种脂质体流感疫苗 |
AU2010270722B2 (en) | 2009-07-06 | 2015-06-04 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
WO2011005772A1 (en) | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
CN101886084B (zh) * | 2010-03-17 | 2012-05-30 | 王世霞 | 一种密码子优化的h3ha/xj3-07基因及其核酸疫苗 |
WO2012006367A2 (en) | 2010-07-06 | 2012-01-12 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
WO2012097346A1 (en) | 2011-01-13 | 2012-07-19 | Variation Biotechnologies, Inc. | Compositions and methods for treating viral infections |
BR112013018074A2 (pt) | 2011-01-13 | 2020-12-01 | Variation Biotechnologies, Inc. | métodos para a preparação de vesículas e formulações produzidas a partir dessas |
WO2013072768A2 (en) | 2011-11-18 | 2013-05-23 | Variation Biotechnologies, Inc. | Synthetic derivatives of mpl and uses thereof |
EP2802353A4 (en) | 2012-01-12 | 2015-12-02 | Variation Biotechnologies Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS |
RU2698906C2 (ru) | 2012-01-27 | 2019-09-02 | Вэриэйшн Биотекнолоджиз, Инк. | Способы и композиции для терапевтических агентов |
KR101588334B1 (ko) * | 2013-07-02 | 2016-01-27 | 대한민국 | 강독화된 인플루엔자 바이러스 변이주 |
KR101493613B1 (ko) * | 2013-10-25 | 2015-02-13 | 위스콘신 얼럼나이 리서어치 화운데이션 | H3 말 인플루엔자 a 바이러스 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683137A (en) * | 1982-04-16 | 1987-07-28 | Cornell Research Foundation, Inc. | Temperature sensitive reassortant viruses and a vaccine against equine influenza |
GB8300467D0 (en) * | 1983-01-08 | 1983-02-09 | Wellcome Found | Equine influenza |
US4920213A (en) * | 1985-06-20 | 1990-04-24 | Biotechnology Research Partners, Ltd. | Method and compositions useful in preventing equine influenza |
US4631191A (en) * | 1985-06-20 | 1986-12-23 | Biotechnology Research Partners, Ltd. | Methods and compositions useful in preventing equine influenza |
US4619827A (en) * | 1985-10-07 | 1986-10-28 | Neogen Corporation | Method for administering equine vaccines and compositions therefor |
US4689224A (en) * | 1985-10-07 | 1987-08-25 | Neogen Corporation | Method for administering vaccines containing equine leukokines and compositions therefor |
ZA973642B (en) * | 1996-04-26 | 1997-11-25 | Merck & Co Inc | DNA vaccine formulations. |
AU8392898A (en) * | 1997-07-14 | 1999-02-10 | Powerject Vaccines, Inc. | Method of dna vaccination using dna encoding antigen and encoding il6 |
US6482414B1 (en) * | 1998-08-13 | 2002-11-19 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US6177082B1 (en) * | 1998-08-13 | 2001-01-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US6398774B1 (en) * | 1999-09-29 | 2002-06-04 | Heska Corporation | Intranasal delivery system |
US20030008000A1 (en) * | 2001-03-08 | 2003-01-09 | Wong Jonathan P. | DNA vaccine using liposome-encapsulated plasmid DNA encoding for hemagglutinin protein of influenza virus |
-
2004
- 2004-04-16 CA CA002523676A patent/CA2523676A1/en not_active Abandoned
- 2004-04-16 JP JP2006513117A patent/JP2007525456A/ja not_active Withdrawn
- 2004-04-16 MX MXPA05012199A patent/MXPA05012199A/es not_active Application Discontinuation
- 2004-04-16 AU AU2004263816A patent/AU2004263816A1/en not_active Abandoned
- 2004-04-16 US US10/826,929 patent/US7244435B2/en not_active Expired - Fee Related
- 2004-04-16 KR KR1020057021763A patent/KR20060035602A/ko not_active Application Discontinuation
- 2004-04-16 BR BRPI0410091-3A patent/BRPI0410091A/pt not_active IP Right Cessation
- 2004-04-16 EP EP04785889A patent/EP1623015A4/en not_active Withdrawn
- 2004-04-16 WO PCT/US2004/011998 patent/WO2005014778A2/en active Application Filing
- 2004-04-16 NZ NZ543196A patent/NZ543196A/en unknown
- 2004-04-16 CN CNA2004800133169A patent/CN1925870A/zh active Pending
-
2005
- 2005-11-14 ZA ZA200509187A patent/ZA200509187B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20060035602A (ko) | 2006-04-26 |
EP1623015A4 (en) | 2007-10-10 |
EP1623015A2 (en) | 2006-02-08 |
WO2005014778A2 (en) | 2005-02-17 |
AU2004263816A1 (en) | 2005-02-17 |
CN1925870A (zh) | 2007-03-07 |
WO2005014778A3 (en) | 2006-10-05 |
US7244435B2 (en) | 2007-07-17 |
CA2523676A1 (en) | 2005-02-17 |
US20050032732A1 (en) | 2005-02-10 |
JP2007525456A (ja) | 2007-09-06 |
MXPA05012199A (es) | 2006-02-10 |
ZA200509187B (en) | 2007-12-27 |
NZ543196A (en) | 2008-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |