BRPI0409552A - derivado de fosfato de um composto hidróxi fenólico, método para a preparação do mesmo, derivado de fosfato de propofol ou um derivado de propofol e método para incrementar a biodisponibilidade de um composto hidróxi fenólico - Google Patents

derivado de fosfato de um composto hidróxi fenólico, método para a preparação do mesmo, derivado de fosfato de propofol ou um derivado de propofol e método para incrementar a biodisponibilidade de um composto hidróxi fenólico

Info

Publication number
BRPI0409552A
BRPI0409552A BRPI0409552-9A BRPI0409552A BRPI0409552A BR PI0409552 A BRPI0409552 A BR PI0409552A BR PI0409552 A BRPI0409552 A BR PI0409552A BR PI0409552 A BRPI0409552 A BR PI0409552A
Authority
BR
Brazil
Prior art keywords
hydroxy compound
phenolic hydroxy
propofol
derivative
phosphate derivative
Prior art date
Application number
BRPI0409552-9A
Other languages
English (en)
Inventor
Simon Michael West
David Kannar
Original Assignee
Vital Health Sciences Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vital Health Sciences Pty Ltd filed Critical Vital Health Sciences Pty Ltd
Publication of BRPI0409552A publication Critical patent/BRPI0409552A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

Abstract

"DERIVADO DE FOSFATO DE UM COMPOSTO HIDRóXI FENóLICO, MéTODO PARA A PREPARAçãO DO MESMO, DERIVADO DE FOSFATO DE PROPOFOL OU UM DERIVADO DE PROPOFOL E MéTODO PARA INCREMENTAR A BIODISPONIBILIDADE DE UM COMPOSTO HIDRóXI FENóLICO". De acordo com a invenção, é apresentado um derivado de fosfato de um composto hidróxi fenólico que compreende o produto da reação das seguintes etapas: (d) reação do composto hidróxi fenólico com um <244>:<sym> dialdeído de alquila ou um poliidróxi dialdeído do tipo açúcar para formar um hemiacetal; (e) redução do grupo aldeído terminal no produto da etapa (a) como um grupo hidroxila; e (f) fosforilação do grupo hidroxila formado na etapa (b) para produzir um derivado de fosfato do composto hidróxi fenólico.
BRPI0409552-9A 2003-04-15 2004-04-14 derivado de fosfato de um composto hidróxi fenólico, método para a preparação do mesmo, derivado de fosfato de propofol ou um derivado de propofol e método para incrementar a biodisponibilidade de um composto hidróxi fenólico BRPI0409552A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003901815A AU2003901815A0 (en) 2003-04-15 2003-04-15 Phosphate derivatives
PCT/AU2004/000491 WO2004092187A1 (en) 2003-04-15 2004-04-14 Phosphate derivatives

Publications (1)

Publication Number Publication Date
BRPI0409552A true BRPI0409552A (pt) 2006-04-18

Family

ID=31500852

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409552-9A BRPI0409552A (pt) 2003-04-15 2004-04-14 derivado de fosfato de um composto hidróxi fenólico, método para a preparação do mesmo, derivado de fosfato de propofol ou um derivado de propofol e método para incrementar a biodisponibilidade de um composto hidróxi fenólico

Country Status (10)

Country Link
US (1) US20070135390A1 (pt)
EP (1) EP1615935A4 (pt)
JP (1) JP2006523622A (pt)
KR (1) KR20060006785A (pt)
CN (1) CN1774442A (pt)
AU (1) AU2003901815A0 (pt)
BR (1) BRPI0409552A (pt)
CA (1) CA2521837A1 (pt)
MX (1) MXPA05010509A (pt)
WO (1) WO2004092187A1 (pt)

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Publication number Publication date
CN1774442A (zh) 2006-05-17
JP2006523622A (ja) 2006-10-19
CA2521837A1 (en) 2004-10-28
EP1615935A1 (en) 2006-01-18
AU2003901815A0 (en) 2003-05-01
US20070135390A1 (en) 2007-06-14
MXPA05010509A (es) 2005-11-16
EP1615935A4 (en) 2008-04-23
WO2004092187A1 (en) 2004-10-28
KR20060006785A (ko) 2006-01-19

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