BRPI0407215A - Derivados de azepinas tricìclicas, processo de preparação dos mesmos e as composições farmacêuticas que contêm os mesmos - Google Patents
Derivados de azepinas tricìclicas, processo de preparação dos mesmos e as composições farmacêuticas que contêm os mesmosInfo
- Publication number
- BRPI0407215A BRPI0407215A BR0407215-4A BRPI0407215A BRPI0407215A BR PI0407215 A BRPI0407215 A BR PI0407215A BR PI0407215 A BRPI0407215 A BR PI0407215A BR PI0407215 A BRPI0407215 A BR PI0407215A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- pharmaceutical compositions
- compositions containing
- preparing
- tricyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"DERIVADOS DE AZEPINAS TRICìCLICAS, PROCESSO DE PREPARAçãO DOS MESMOS E AS COMPOSIçõES FARMACêUTICAS QUE CONTêM OS MESMOS". A presente invenção refere-se a compostos de fórmula (I) na qual (a) representa um grupamento benzo ou pirido, eventualmente fundido ou na posição (2-3, 3-4 ou 4-5) e eventualmente substituído, (W) representa um grupamento (X-Y ou Y-X) com (X) representando um grupamento (b) e Y representando um átomo de oxigênio ou um grupamento (N-R~ 3~), n representa zero ou um número inteiro tal que 1 <243> n <243> 6 (G, R~ 1~, R~ 2~ e R~ 3~) são tais como definidos no relatório descritivo, enanciómeros, diaestereoisómeros dos mesmos, assim como sais de adição dos mesmos a um ácido ou a uma base farmaceuticamente aceitável. Medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0301181A FR2850654A1 (fr) | 2003-02-03 | 2003-02-03 | Nouveaux derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
PCT/FR2004/000234 WO2004069843A1 (fr) | 2003-02-03 | 2004-02-03 | Derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0407215A true BRPI0407215A (pt) | 2006-01-24 |
Family
ID=32696289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0407215-4A BRPI0407215A (pt) | 2003-02-03 | 2004-02-03 | Derivados de azepinas tricìclicas, processo de preparação dos mesmos e as composições farmacêuticas que contêm os mesmos |
Country Status (18)
Country | Link |
---|---|
US (1) | US20060079677A1 (pt) |
EP (1) | EP1590355A1 (pt) |
JP (1) | JP2006515350A (pt) |
KR (1) | KR20050096970A (pt) |
CN (1) | CN1745087A (pt) |
AR (1) | AR043691A1 (pt) |
AU (1) | AU2004208890A1 (pt) |
BR (1) | BRPI0407215A (pt) |
CA (1) | CA2513059A1 (pt) |
EA (1) | EA200501232A1 (pt) |
FR (1) | FR2850654A1 (pt) |
MA (1) | MA27576A1 (pt) |
MX (1) | MXPA05007977A (pt) |
MY (1) | MY138865A (pt) |
NO (1) | NO20054092L (pt) |
PL (1) | PL376621A1 (pt) |
WO (1) | WO2004069843A1 (pt) |
ZA (1) | ZA200505430B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2049493B1 (en) | 2006-07-31 | 2012-03-21 | Cadila Healthcare Limited | Compounds suitable as modulators of hdl |
MX2011008328A (es) | 2009-02-05 | 2011-11-04 | Immunogen Inc | Derivados novedosos de benzodiacepina. |
DK2675479T3 (en) | 2011-02-15 | 2016-04-11 | Immunogen Inc | cytotoxic benzodiazepine |
WO2014031566A1 (en) | 2012-08-22 | 2014-02-27 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
WO2016036804A1 (en) | 2014-09-03 | 2016-03-10 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
SG11201701455SA (en) | 2014-09-03 | 2017-03-30 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
US20180346488A1 (en) | 2017-04-20 | 2018-12-06 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives and conjugates thereof |
EP3732178A1 (en) | 2017-12-28 | 2020-11-04 | ImmunoGen, Inc. | Benzodiazepine derivatives |
CN113661172A (zh) | 2019-03-29 | 2021-11-16 | 伊缪诺金公司 | 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1204680B (de) * | 1963-05-31 | 1965-11-11 | Thomae Gmbh Dr K | Verfahren zur Herstellung von in 5-Stellung substituierten 6-Oxo-5, 6-dihydro-11H-pyrido [2, 3-b][1, 4]benzodiazepinen |
DE1238479B (de) * | 1964-01-28 | 1967-04-13 | Thomae Gmbh Dr K | Verfahren zur Herstellung von 5, 6-Dihydro-5-oxo-11H-pyrido-[2, 3-b] [1, 5]-benzodiazepinen |
DE1251767B (de) * | 1964-02-28 | 1968-04-18 | Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß | Verfahren zur Herstellung von neuen m 6 Stellung substituierten 5 6 Dihydro-5oxo HH pyrido[2,3-b] [l,5]benzodiazepinen |
FR6006M (pt) * | 1965-01-05 | 1968-05-06 | ||
DE2424811C3 (de) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
US3966736A (en) * | 1975-04-07 | 1976-06-29 | The Upjohn Company | 2,9-Dihydro-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]-benzodiazepin-3-ones |
DE2644121A1 (de) * | 1976-09-30 | 1978-04-06 | Thomae Gmbh Dr K | Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
IT1130973B (it) * | 1980-03-17 | 1986-06-18 | Microsules Argentina Sa De S C | Processo per la preparazione di derivati di 5,11-di-idro-6h-pirido(2,3-b) (1,4)-benzodiazepin-6-one,derivati finali ed intermedi di sintesi in tal modo ottenuti |
DE3643666A1 (de) * | 1986-12-20 | 1988-06-30 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
IT8721978A0 (it) * | 1987-09-21 | 1987-09-21 | Angeli Inst Spa | Nuovi derivati ammidinici triciclici. |
DE3818299A1 (de) * | 1988-05-30 | 1989-12-07 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5366972A (en) * | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
ATE91128T1 (de) * | 1989-04-20 | 1993-07-15 | Boehringer Ingelheim Pharma | 5,11-dihydro-6h-dipyrido (3,2-b:2',3'-e>diazepin- 6-one und deren verwendung in der vorbeugung und behandlung von aids. |
EP0393604B1 (en) * | 1989-04-20 | 1997-12-29 | Boehringer Ingelheim Pharmaceuticals Inc. | 6,11-Dihydro-5H-pyrido(2,3-b)(1,5,)benzodiazepin-5-ones and thiones and their use in the prevention or treatment of AIDS |
BE1004596A4 (fr) * | 1990-09-26 | 1992-12-22 | Therabel Res S A N V | Derives de methylpiperazinoazepine, leur preparation et leur utilisation. |
US5087625A (en) * | 1990-10-19 | 1992-02-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyridodiazepines and their use in the prevention or treatment of HIV infection |
AU5883794A (en) * | 1993-01-20 | 1994-08-15 | A. Menarini Industrie Farmaceutiche Riunite S.R.L. | Diazepin derivatives and antiviral compositions |
US6090803A (en) * | 1998-07-24 | 2000-07-18 | American Home Products Corporation | Tricyclic vasopressin agonists |
-
2003
- 2003-02-03 FR FR0301181A patent/FR2850654A1/fr not_active Withdrawn
-
2004
- 2004-01-30 MY MYPI20040277A patent/MY138865A/en unknown
- 2004-02-03 AU AU2004208890A patent/AU2004208890A1/en not_active Abandoned
- 2004-02-03 KR KR1020057014292A patent/KR20050096970A/ko not_active Application Discontinuation
- 2004-02-03 WO PCT/FR2004/000234 patent/WO2004069843A1/fr not_active Application Discontinuation
- 2004-02-03 CA CA002513059A patent/CA2513059A1/fr not_active Abandoned
- 2004-02-03 JP JP2006500158A patent/JP2006515350A/ja active Pending
- 2004-02-03 CN CNA2004800033851A patent/CN1745087A/zh active Pending
- 2004-02-03 AR ARP040100322A patent/AR043691A1/es unknown
- 2004-02-03 PL PL376621A patent/PL376621A1/pl not_active Application Discontinuation
- 2004-02-03 BR BR0407215-4A patent/BRPI0407215A/pt not_active IP Right Cessation
- 2004-02-03 US US10/543,729 patent/US20060079677A1/en not_active Abandoned
- 2004-02-03 ZA ZA200505430A patent/ZA200505430B/en unknown
- 2004-02-03 MX MXPA05007977A patent/MXPA05007977A/es unknown
- 2004-02-03 EA EA200501232A patent/EA200501232A1/ru unknown
- 2004-02-03 EP EP04707554A patent/EP1590355A1/fr not_active Withdrawn
-
2005
- 2005-07-11 MA MA28377A patent/MA27576A1/fr unknown
- 2005-09-02 NO NO20054092A patent/NO20054092L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO20054092L (no) | 2005-09-02 |
KR20050096970A (ko) | 2005-10-06 |
WO2004069843A1 (fr) | 2004-08-19 |
EP1590355A1 (fr) | 2005-11-02 |
JP2006515350A (ja) | 2006-05-25 |
MXPA05007977A (es) | 2005-09-20 |
MY138865A (en) | 2009-08-28 |
AR043691A1 (es) | 2005-08-10 |
EA200501232A1 (ru) | 2006-02-24 |
FR2850654A1 (fr) | 2004-08-06 |
MA27576A1 (fr) | 2005-10-03 |
ZA200505430B (en) | 2006-09-27 |
CA2513059A1 (fr) | 2004-08-19 |
US20060079677A1 (en) | 2006-04-13 |
PL376621A1 (pl) | 2006-01-09 |
AU2004208890A1 (en) | 2004-08-19 |
CN1745087A (zh) | 2006-03-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE59108930D1 (de) | Cyclische Iminoderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung | |
DE59209769D1 (de) | Cyclische Iminoderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung | |
AR018634A1 (es) | Derivados de benzo(b)tiepin-1,1,-dioxido, procedimiento para su preparacion, medicamentos conteniendo estos compuestos, procedimiento para la preparacion de medicamentos y su empleo para la preparacion de medicamentos. | |
BR0108456A (pt) | Composto, uso de um composto, métodos de tratamento ou de profilaxia de distúrbios psicóticos ou distúrbios de deterioração intelectual e de doenças humanas, e ,processo para preparação de um composto | |
BR0317283A (pt) | Derivados heterocìclicos de flúor-glicosìdeo, medicamentos contendo estes compostos e seu uso | |
AR007440A1 (es) | Compuestos triciclos fenilamino sustituidos y composiciones farmaceuticas de los mismos. | |
DE59308940D1 (de) | Cyclische Iminoderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel | |
BR0111230A (pt) | Composto, e, uso e processo para a preparação do mesmo | |
HUP0203122A2 (hu) | Fab I inhibitorok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
BRPI0110955B8 (pt) | derivados de tropano composição farmacêutica, uso dos mesmos na fabricação de um medicamento bem como processo para a preparação dos mesmos. | |
BRPI0416276A (pt) | lactames macrocìclicos e uso farmacêutico dos mesmos | |
BR0014225A (pt) | Derivados de pirazol | |
AR048567A1 (es) | Derivados de benzoxazinona, su preparacion y composiciones farmaceuticas. | |
NO20054092L (no) | Nye tricykliske azepinforbindelser, fremgangsmater for deres fremstilling og farmasoytiske sammensetninger inneholdende dem | |
BR0308765A (pt) | Compostos (4,2-dissubstituìdo-tiazol-5-il)amina como inibidores de pde7 | |
BR0315800A (pt) | Derivados de imidazopiridina, seu processo de preparação e as composições farmacêuticas que os contêm | |
BR0016953A (pt) | Derivados de 4-fenil-1-piperazinila, -piperidinila e tetraidropiridila substituìdo por halogênio, composto, composição farmacêutica, uso e método de tratamento | |
BR0214649A (pt) | Derivados de aminotetralina como antagonistas do receptor muscarìnico | |
BR0308807A (pt) | Compostos tiazol-2-il-imina como inibidores de pde-7 | |
HUP0402602A2 (hu) | Eljárás echinokandin-származékok előállítására, ezek alkalmazása, ezeket tartalmazó gyógyszerkészítmények és intermedierek | |
BR0202681A (pt) | Compostos de octaidro-2h-pirido[1,2a]pirazina, um processo para sua preparação e composições farmacêuticas contendo-as | |
DE69710909D1 (de) | Substituierte tetrahydropyridinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel | |
BR0307776A (pt) | Derivados de ácidos aminados, o respectivo processo de preparo e as composições farmacêuticas que os contêm | |
EA200100725A3 (ru) | Новые бензотиадиазиновые соединения, способ их получения и их содержащие фармацевтические композиции | |
EA200101204A1 (ru) | Новые бициклические соединения аминопиразинона, способ их получения и содержащие их фармацевтические композиции |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A, 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |