BRPI0404635A - processo para a obtenção de esteróides seco derivados do ergostano - Google Patents

processo para a obtenção de esteróides seco derivados do ergostano

Info

Publication number
BRPI0404635A
BRPI0404635A BRPI0404635-8A BRPI0404635A BRPI0404635A BR PI0404635 A BRPI0404635 A BR PI0404635A BR PI0404635 A BRPI0404635 A BR PI0404635A BR PI0404635 A BRPI0404635 A BR PI0404635A
Authority
BR
Brazil
Prior art keywords
ergostane
derived
steroids
obtaining
dry
Prior art date
Application number
BRPI0404635-8A
Other languages
English (en)
Inventor
Therezinha Coelho Ba Tomassini
Ivone Maria Ribeiro
Ana Claudia Fernandes Amaral
Milena Botelho Pereira Soares
Ricardo Ribeiro Dos Santos
Original Assignee
Fundacao Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Oswaldo Cruz filed Critical Fundacao Oswaldo Cruz
Priority to BRPI0404635A priority Critical patent/BRPI0404635B8/pt
Priority to PCT/BR2005/000223 priority patent/WO2006045171A2/en
Publication of BRPI0404635A publication Critical patent/BRPI0404635A/pt
Publication of BRPI0404635B1 publication Critical patent/BRPI0404635B1/pt
Publication of BRPI0404635B8 publication Critical patent/BRPI0404635B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA A OBTENçãO DE ESTERóIDES SECO DERIVADOS DO ERGOSTANO". A presente invenção refere-se a um processo de obtenção de esteróides seco derivados do ergostano, como as fisalinas, compreendendo as etapas de: (a) moagem de partes secas de planta(s) da família Solanaceae; (b) tratamento das ditas partes de planta(s) da etapa (a) com solução salina de cloreto de sódio (tampão fisiológico) por um período de tempo apropriado; (c) filtração do soluto proveniente da etapa (b) e, então, particioná-lo em diclorometano ou solvente imiscível em água, como clorofórmio ou acetato de etila; (d) lavagem da fase orgânica resultante da etapa (c) com água destilada e posterior filtração em sulfato de magnésio anidro ou qualquer outro secante insolúvel em água; (e) evaporação da solução resultante da etapa (d) , fornecendo uma fração enriquecida em esteróides seco derivados do ergostano; (f) separação dos esteróides seco derivados do ergostano por cromatografia líquida de média pressão (MPLC) e subseqüente caracterização espectroscópia.
BRPI0404635A 2004-10-25 2004-10-25 processo para a obtenção de esteróides seco derivados do ergostano BRPI0404635B8 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0404635A BRPI0404635B8 (pt) 2004-10-25 2004-10-25 processo para a obtenção de esteróides seco derivados do ergostano
PCT/BR2005/000223 WO2006045171A2 (en) 2004-10-25 2005-10-25 Process for obtaining dry steroids derivative from ergostane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0404635A BRPI0404635B8 (pt) 2004-10-25 2004-10-25 processo para a obtenção de esteróides seco derivados do ergostano

Publications (3)

Publication Number Publication Date
BRPI0404635A true BRPI0404635A (pt) 2007-02-21
BRPI0404635B1 BRPI0404635B1 (pt) 2019-01-15
BRPI0404635B8 BRPI0404635B8 (pt) 2021-05-25

Family

ID=36228134

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0404635A BRPI0404635B8 (pt) 2004-10-25 2004-10-25 processo para a obtenção de esteróides seco derivados do ergostano

Country Status (2)

Country Link
BR (1) BRPI0404635B8 (pt)
WO (1) WO2006045171A2 (pt)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61143324A (ja) * 1984-12-17 1986-07-01 Takeo Haneda 血圧、血糖改善食品
US20020103386A1 (en) * 1999-10-14 2002-08-01 Therezinha C. B. Tomassini Process for isolating physalins from plants and pharmaceutical compositions containing physalins

Also Published As

Publication number Publication date
BRPI0404635B8 (pt) 2021-05-25
WO2006045171A2 (en) 2006-05-04
WO2006045171A3 (en) 2007-10-04
BRPI0404635B1 (pt) 2019-01-15

Similar Documents

Publication Publication Date Title
Wang et al. Constituents of the flowers of Punica granatum
Liu et al. Advancement in the chemical analysis and quality control of flavonoid in Ginkgo biloba
Stebelska Fungal hallucinogens psilocin, ibotenic acid, and muscimol: analytical methods and biologic activities
CN102101893B (zh) 一种富集纯化芦荟中芦荟多糖的方法
Park et al. Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer’s disease
Kang et al. Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model
CN102093175B (zh) 一种从无患子科植物荔枝、龙眼提取白坚木皮醇的方法
Rout et al. Anti-hyperglycemic effect Annona reticulata L. leaves on experimental diabetic rat model
CN101270142A (zh) 油茶皂素的制备方法
WO2011140676A1 (zh) 用于防治阿尔茨海默病和血管性痴呆及其混合型等疾病的天麻植物提取物及其制备方法
RS59889B1 (sr) Metoda odvajanja izoprenskih sastojaka gvajule
CN102416027B (zh) 银杏活性成分萃取分离方法及萃取的活性物质在治疗心脑血管疾病药物中的应用
CN106478577B (zh) 一种艾纳香素及其结构类似物的分离提纯方法
CN104606276B (zh) 一种从柿叶中提取小分子柿叶黄酮的方法
BRPI0404635A (pt) processo para a obtenção de esteróides seco derivados do ergostano
Lavoie et al. DFT Calculations and ROESY NMR Data for the Diastereochemical Characterization of Cytotoxic Tetraterpenoids from the Oleoresin of Abies balsamea
Lee et al. Development and optimization of a novel simultaneous microwave-assisted extraction and adsorbent treatment process for separation and recovery of paclitaxel from plant cell cultures
CN102093244A (zh) 一种神经酰胺的提取方法
CN104224813A (zh) 一种药物组合物及其制备方法与用途
JP2006519184A5 (pt)
JP2006519184A (ja) 天然資源からのパクリタキセルの改良された単離及び精製プロセス
CN1424319A (zh) 山茱萸提取物及其制备方法和用途
CN103044424B (zh) 一种富集纯化苦参中苦参碱的方法
CN110551139B (zh) 具有抗阿尔兹海默病活性的化合物及其制备方法和应用
CN106939031B (zh) 一种螺旋甾碱烷型糖苷生物碱及其制备方法与用途

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/01/2019, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/10/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B15V Prolongation of time limit allowed
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2854 DE 16/09/2025 POR TER SIDO INDEVIDA.