BRPI0314654B8 - método de análise de heparinas ou de heparinas de baixo peso molecular, para buscar a presença de cadeias de oligossacarídeos cuja terminação é modificada por uma ligação 1,6-anidro, e derivados das mesmas - Google Patents

método de análise de heparinas ou de heparinas de baixo peso molecular, para buscar a presença de cadeias de oligossacarídeos cuja terminação é modificada por uma ligação 1,6-anidro, e derivados das mesmas

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Publication number
BRPI0314654B8
BRPI0314654B8 BRPI0314654A BR0314654A BRPI0314654B8 BR PI0314654 B8 BRPI0314654 B8 BR PI0314654B8 BR PI0314654 A BRPI0314654 A BR PI0314654A BR 0314654 A BR0314654 A BR 0314654A BR PI0314654 B8 BRPI0314654 B8 BR PI0314654B8
Authority
BR
Brazil
Prior art keywords
heparins
molecular weight
low molecular
analysis
search
Prior art date
Application number
BRPI0314654A
Other languages
English (en)
Other versions
BR0314654A (pt
BRPI0314654B1 (pt
Inventor
Viskov Christian
Mourier Pierre
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0211724A external-priority patent/FR2844808B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0314654A publication Critical patent/BR0314654A/pt
Publication of BRPI0314654B1 publication Critical patent/BRPI0314654B1/pt
Publication of BRPI0314654B8 publication Critical patent/BRPI0314654B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

"método de determinação de grupamentos específicos que constituem as heparinas ou as heparinas de baixo peso molecular". a presente invenção refere-se a um método de análise das heparinas ou heparinas de baixo peso molecular, caracterizado pelo fato de a amostra a dosar ser despolimerizada por ação de heparinases, depois, se for o caso, o despolimerizado obtido ser reduzido, depois se fazer uma análise por cromatografia líquida de desempenho.
BRPI0314654A 2002-09-23 2003-09-22 método de análise de heparinas ou de heparinas de baixo peso molecular, para buscar a presença de cadeias de oligossacarídeos cuja terminação é modificada por uma ligação 1,6-anidro, e derivados das mesmas BRPI0314654B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0211724A FR2844808B1 (fr) 2002-09-23 2002-09-23 Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US42248202P 2002-10-31 2002-10-31
PCT/FR2003/002782 WO2004027087A2 (fr) 2002-09-23 2003-09-22 Methode de determination de groupements specifiques constituant les heparines

Publications (3)

Publication Number Publication Date
BR0314654A BR0314654A (pt) 2005-08-02
BRPI0314654B1 BRPI0314654B1 (pt) 2016-01-05
BRPI0314654B8 true BRPI0314654B8 (pt) 2021-05-25

Family

ID=32031841

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0314654A BRPI0314654B8 (pt) 2002-09-23 2003-09-22 método de análise de heparinas ou de heparinas de baixo peso molecular, para buscar a presença de cadeias de oligossacarídeos cuja terminação é modificada por uma ligação 1,6-anidro, e derivados das mesmas

Country Status (18)

Country Link
EP (1) EP1558755B1 (pt)
JP (1) JP4373917B2 (pt)
KR (1) KR20050057550A (pt)
CN (1) CN101747385B (pt)
AU (1) AU2003279430B2 (pt)
BR (1) BRPI0314654B8 (pt)
CA (1) CA2499537A1 (pt)
CO (1) CO5721022A2 (pt)
HK (1) HK1081601A1 (pt)
HR (1) HRP20050273A2 (pt)
IL (1) IL167569A (pt)
MA (1) MA27393A1 (pt)
MX (1) MXPA05001945A (pt)
NO (1) NO20051744L (pt)
PL (1) PL376709A1 (pt)
RS (1) RS20050230A (pt)
RU (1) RU2359037C2 (pt)
WO (1) WO2004027087A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
EP1582531A1 (en) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
FR2880951B1 (fr) * 2005-01-19 2015-09-18 Aventis Pharma Sa Methode d'analyse d'oligosaccharides a partir de plasma sanguin
US8101733B1 (en) 2006-06-27 2012-01-24 Momenta Pharmaceuticals, Inc. Methods of evaluating mixtures of polysaccharides
WO2008068854A1 (ja) 2006-12-05 2008-06-12 Glycoscience Laboratories, Inc. 変形性関節症の治療剤
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
US7790466B1 (en) 2007-01-26 2010-09-07 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2011090948A1 (en) 2010-01-19 2011-07-28 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN103755823B (zh) * 2013-12-12 2016-09-28 中国海洋大学 一种硫酸软骨素中硫酸角质素的纯化与检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8102987A (en) * 1986-10-02 1988-04-21 Massachusetts Institute Of Technology Neutralizing anticoagulant activities of low molecular weight heparin
US6190875B1 (en) * 1997-09-02 2001-02-20 Insight Strategy & Marketing Ltd. Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe

Also Published As

Publication number Publication date
JP2006500019A (ja) 2006-01-05
CO5721022A2 (es) 2007-01-31
HRP20050273A2 (en) 2006-05-31
CA2499537A1 (fr) 2004-04-01
KR20050057550A (ko) 2005-06-16
MA27393A1 (fr) 2005-06-01
BR0314654A (pt) 2005-08-02
WO2004027087A3 (fr) 2005-06-09
NO20051744L (no) 2005-04-08
EP1558755B1 (fr) 2012-10-24
PL376709A1 (pl) 2006-01-09
BRPI0314654B1 (pt) 2016-01-05
RS20050230A (en) 2007-06-04
RU2005112240A (ru) 2005-11-20
JP4373917B2 (ja) 2009-11-25
HK1081601A1 (en) 2006-05-19
AU2003279430B2 (en) 2008-09-11
EP1558755A2 (fr) 2005-08-03
AU2003279430A1 (en) 2004-04-08
RU2359037C2 (ru) 2009-06-20
IL167569A (en) 2010-12-30
CN101747385A (zh) 2010-06-23
CN101747385B (zh) 2013-03-06
WO2004027087A2 (fr) 2004-04-01
MXPA05001945A (es) 2005-04-28

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