BR9915622A - Acetal benzilmaltosìdeos como inibidores de proliferação de células de músculo liso - Google Patents
Acetal benzilmaltosìdeos como inibidores de proliferação de células de músculo lisoInfo
- Publication number
- BR9915622A BR9915622A BR9915622-9A BR9915622A BR9915622A BR 9915622 A BR9915622 A BR 9915622A BR 9915622 A BR9915622 A BR 9915622A BR 9915622 A BR9915622 A BR 9915622A
- Authority
- BR
- Brazil
- Prior art keywords
- carbon atoms
- substituted
- phenyl
- alkyl
- perfluoroalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Patente de Invenção: <B>"ACETAL BENZILMALTOSìDEOS COMO INIBIDORES DE PROLIFERAçãO DE CéLULAS DE MúSCULO LISO"<D>. Esta invenção provê inibidores de proliferação de células de músculo liso de fórmula I tendo a estrutura em que W é S, SO, SO~ 2~, NR; Y é O, S, NR ou CH~ 2~; R é hidrogênio ou alquila de 1-6 átomos de carbono, perfluoroalquila de 1-6 átomos de carbono, acila de 2-7 átomos de carbono, perfluoroacila de 2-7 átomos de carbono; R¹ e R^ 7^ são, cada, independentemente, alquila de 1-6 átomos de carbono, perfluoroalquila de 1-6 átomos de carbono, haloalquila de 1-6 átomos de carbono, nitroalquila de 1-6 átomos de carbono, cianoalquila de 1-6 átomos de carbono, alcoxialquila de 2-12 átomos de carbono, nitriloalquila de 1-6 átomos de carbono, fenila mono-, di-, ou trissubstituída com R^ 8^, fenilalquila de 7-10 átomos de carbono, em que o anel fenila é mono-, di- ou tri-substituído com R^ 8^, piridila substituída com R^ 8^, furila substituída com R^ 8^, tienila substituída com R^ 8^, e tiazolila substituída com R^ 8^; R² é hidrogênio, R³, R^ 4^, R^ 5^ e R^ 6^ são cada, independentemente, hidrogênio, acila de 2-7 átomos de carbono, perfluoroacila de 2-7 átomos de carbono, alquila de 1-6 átomos de carbono, perfluoroalquila de 1-6 átomos de carbono, benzila, em que a porção fenila é mono- , di- ou trissubstituída com R^ 8^, benzoíla, em que a porção fenila é mono-, di- ou trissubstituída com R^ 8^; R^ 8^ é hidrogênio, alquila de 1-6 átomos de carbono, perfluoroalquila de 1-6 átomos de carbono, alcóxi de 1-6 átomos de carbono, perfluoroalcóxi de 1-6 átomos de carbono, fenila, - CN, -NO~ 2~- halogênio, ou -CF~ 3~; R^ 9^ é hidrogênio, alquila de 1-6 átomos de carbono, perfluoroalquila de 1-6 átomos de carbono, alcóxi de 1-6 átomos de carbono, perfluoroalcóxi de 1-6 átomos de carbono, fenila, - CN, -NO~ 2~, halogênio, -NHCO~ 2~R^ 13^, -NHSO~ 2~R^ 13^, - NR^ 14^R^ 15^, Favor copiar pág. 58 R^ 10^, R^ 11^, e R^ 12^ são cada, independentemente, hidrogênio, alquila de 1-6 átomos de carbono, perfluoroalquila de 1-6 átomos de carbono, alcóxi de 1-6 átomos de carbono, perfluoroalcóxi de 1-6 átomos de carbono, fenila, -CN, -NO~ 2~, halogênio, acila de 2-7 átomos de carbono, perfluoroacila de 2-7 átomos de carbono, ou benzoíla, em que a porção fenila do grupo benzoíla é opcionalmente mono-, di- ou trissubstituída com alquila de 1-6 átomos de carbono, alcóxi de 1-6 átomos de carbono, -CN, -NO~ 2~, halogênio, ou -CF~ 3~; R^ 13^ é alquila de 1-6 átomos de carbono, perfluoroalquila de 1-6 átomos de carbono, fenila ou fenila substituída com halogênio; R^ 14^ e R^ 15^ são, cada, independentemente, hidrogênio, alquila de 1-6 átomos de carbono, perfluoroalquila de 1-6 átomos de carbono, acila de 2-7 átomos de carbono, perfluoroacila de 2-7 átomos de carbono; n = 0-3, ou um sal farmaceuticamente aceitável dos mesmos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19898498A | 1998-11-24 | 1998-11-24 | |
| PCT/US1999/027781 WO2000034338A2 (en) | 1998-11-24 | 1999-11-23 | Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9915622A true BR9915622A (pt) | 2001-08-14 |
Family
ID=22735729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9915622-9A BR9915622A (pt) | 1998-11-24 | 1999-11-23 | Acetal benzilmaltosìdeos como inibidores de proliferação de células de músculo liso |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1133303A2 (pt) |
| JP (1) | JP2002531579A (pt) |
| CN (1) | CN1348460A (pt) |
| AU (1) | AU1743800A (pt) |
| BR (1) | BR9915622A (pt) |
| CA (1) | CA2351060A1 (pt) |
| WO (1) | WO2000034338A2 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1333784A (zh) * | 1998-11-24 | 2002-01-30 | 美国家用产品公司 | 用作平滑肌细胞增殖抑制剂的苄基麦芽糖苷 |
| EP1133510A2 (en) * | 1998-11-24 | 2001-09-19 | American Home Products Corporation | Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation |
| JP4236094B2 (ja) * | 2003-02-07 | 2009-03-11 | 本田技研工業株式会社 | 車両用ロック装置 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115745A (en) * | 1994-11-07 | 2000-11-21 | American Home Prod | Acylated benzylglycosides and pharmaceutical compositions containing them |
-
1999
- 1999-11-23 CN CN99813616A patent/CN1348460A/zh active Pending
- 1999-11-23 EP EP99960571A patent/EP1133303A2/en not_active Withdrawn
- 1999-11-23 BR BR9915622-9A patent/BR9915622A/pt not_active Application Discontinuation
- 1999-11-23 WO PCT/US1999/027781 patent/WO2000034338A2/en not_active Application Discontinuation
- 1999-11-23 JP JP2000586780A patent/JP2002531579A/ja active Pending
- 1999-11-23 AU AU17438/00A patent/AU1743800A/en not_active Abandoned
- 1999-11-23 CA CA002351060A patent/CA2351060A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000034338A2 (en) | 2000-06-15 |
| JP2002531579A (ja) | 2002-09-24 |
| WO2000034338A3 (en) | 2000-11-30 |
| EP1133303A2 (en) | 2001-09-19 |
| CN1348460A (zh) | 2002-05-08 |
| CA2351060A1 (en) | 2000-06-15 |
| AU1743800A (en) | 2000-06-26 |
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|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |