BR9915612A - Benzilglicosilamidas como inibidores de proliferação de células do músculo liso - Google Patents

Benzilglicosilamidas como inibidores de proliferação de células do músculo liso

Info

Publication number
BR9915612A
BR9915612A BR9915612-1A BR9915612A BR9915612A BR 9915612 A BR9915612 A BR 9915612A BR 9915612 A BR9915612 A BR 9915612A BR 9915612 A BR9915612 A BR 9915612A
Authority
BR
Brazil
Prior art keywords
carbon atoms
substituted
smooth muscle
inhibitors
hydrogen
Prior art date
Application number
BR9915612-1A
Other languages
English (en)
Inventor
Robert Emmett Mcdevitt
Folake Oluwemimo Adebayo
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9915612A publication Critical patent/BR9915612A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: <B>"BENZILGLICOSILAMIDAS COMO INIBIDORES DE PROLIFERAçãO DE CéLULAS DO MúSCULO LISO"<D>. A invenção proporciona inibidores de proliferação de células do músculo liso de fórmula (I) que apresentam uma estrutura onde Y é C ou N; onde n é 0 - 3; X é (A) onde R¹ e R² são cada um, independentemente, hidrogênio, alquila de 1 a 6 átomos de carbono, halo, acetila, fenila, CF~ 3~, CN, OH, NO~ 2~, NH~ 2~, alcóxi de 1 a 6 átomos de carbono, ou alcoxinitrila de 1 a 6 átomos de carbono; R^ 3^ é hidrogênio, acilamida de 2 a 6 átomos de carbono ou alcóxi de 1 a 6 átomos de carbono; R^ 4^, R^ 5^, R^ 6^, R^ 7^ e R^ 8^ são cada um, independentemente, hidrogênio, acila de 1 a 6 átomos de carbono, benzila substituída com R¹ e R², ou benzoíla substituída com R¹ e R²; R^ 9^ e R^ 10^ são cada um, independentemente, acila de 1 a 6 átomos de carbono, ou os grupos R^ 9^ e R^ 10^ nas posições 4' e 6' da maltose poderão ser tomados juntamente para formar um acetal cíclico que poderá ser substituído com alquila de 1 a 6 átomos de carbono, dois grupos alquila cada um apresentando 1 a 6 átomos de carbono, piridina substituída com R¹, fenila substituída com R¹, benzila substituída com R¹, 2-feniletila substiutuída com R¹, ou 3-fenilpropila substituída com R¹; ou um sal farmaceuticamente aceitável dos mesmos.
BR9915612-1A 1998-11-24 1999-11-23 Benzilglicosilamidas como inibidores de proliferação de células do músculo liso BR9915612A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19843298A 1998-11-24 1998-11-24
PCT/US1999/027780 WO2000031093A2 (en) 1998-11-24 1999-11-23 Benzylglycosylamides as inhibitors of smooth muscle cell proliferation

Publications (1)

Publication Number Publication Date
BR9915612A true BR9915612A (pt) 2001-08-14

Family

ID=22733358

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915612-1A BR9915612A (pt) 1998-11-24 1999-11-23 Benzilglicosilamidas como inibidores de proliferação de células do músculo liso

Country Status (7)

Country Link
EP (1) EP1133508A2 (pt)
JP (1) JP2002530418A (pt)
CN (1) CN1333781A (pt)
AU (1) AU1743700A (pt)
BR (1) BR9915612A (pt)
CA (1) CA2350758A1 (pt)
WO (1) WO2000031093A2 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2350755A1 (en) * 1998-11-24 2000-06-02 Robert Emmett Mcdevitt Benzylglycosylamides as inhibitors of smooth muscle cell proliferation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3655327B2 (ja) * 1994-05-09 2005-06-02 三井化学株式会社 オリゴ糖鎖を有するスチレン誘導体およびその製造方法
DE4436164A1 (de) * 1994-10-10 1996-04-11 Hoechst Ag Neue Kohlenhydratkonjugate als Inhibitoren der Zelladhäsion
CA2350755A1 (en) * 1998-11-24 2000-06-02 Robert Emmett Mcdevitt Benzylglycosylamides as inhibitors of smooth muscle cell proliferation

Also Published As

Publication number Publication date
WO2000031093A2 (en) 2000-06-02
WO2000031093A3 (en) 2000-12-28
CA2350758A1 (en) 2000-06-02
EP1133508A2 (en) 2001-09-19
CN1333781A (zh) 2002-01-30
JP2002530418A (ja) 2002-09-17
AU1743700A (en) 2000-06-13

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired