BR9914984A - Método de produção de uma formulação injetável in vivo de 3he hiperpolarizado, de preparação e de subsequente injeção de 3he gasoso polarizado in vivo, e, de solubilização de 129xe gasoso hiperpolarizado, e, produto hiperpolarizado de fluido farmacêutico injetável in vivo - Google Patents

Método de produção de uma formulação injetável in vivo de 3he hiperpolarizado, de preparação e de subsequente injeção de 3he gasoso polarizado in vivo, e, de solubilização de 129xe gasoso hiperpolarizado, e, produto hiperpolarizado de fluido farmacêutico injetável in vivo

Info

Publication number
BR9914984A
BR9914984A BR9914984-2A BR9914984A BR9914984A BR 9914984 A BR9914984 A BR 9914984A BR 9914984 A BR9914984 A BR 9914984A BR 9914984 A BR9914984 A BR 9914984A
Authority
BR
Brazil
Prior art keywords
hyperous
vivo
hyperpolarized
gaseous
injectable
Prior art date
Application number
BR9914984-2A
Other languages
English (en)
Inventor
Bastiaan Driehuys
Original Assignee
Medi Physics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medi Physics Inc filed Critical Medi Physics Inc
Publication of BR9914984A publication Critical patent/BR9914984A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

"MéTODO DE PRODUçãO DE UMA FORMULAçãO INJETáVEL IN VIVO DE ^ 3^HE HIPERPOLARIZADO, DE PREPARAçãO E DE SUBSEQuENTE INJEçãO DE ^ 3^HE GASOSO POLARIZADO IN VIVO, E, DE SOLUBILIZAçãO DE ^ 129^XE GASOSO HIPERPOLARIZADO, E, PRODUTO HIPERPOLARIZADO DE FLUIDO FARMACêUTICO INJETáVEL IN VIVO" Processos para o aumento da T~ 1~ de formulações de microbolhas injetáveis de ^ 3^He hiperpolarizado incluem a etapa de introduzir o ^ 3^He hiperpolarizado em uma quantidade de microbolhas mantidas dentro de uma câmara e de aumentar a pressão dentro da mesma para facilitar o movimento ou o carregamento do ^ 3^He para dentro das microbolhas. Subsq³entemente, uma quantidade limitada de um líquido transportador ou de uma solução líquida transportadora sozinha, ou pré-misturada com ^ 3^He, pode ser introduzida na microbolha/^ 3^He dentro da câmara para inibir a tendência de o ^ 3^He vazar para fora da bolha. Produtos farmacêuticos relacionados e recipientes associados bem como um processo baseado em evacuação para a rápida misturação e distribuição das bolhas e do ^ 3^He também são descritos. Um processo adicional para dissolução de gás ^ 129^Xe por meio do uso de bolhas como um agente acelerador também é descrito.
BR9914984-2A 1998-11-03 1999-10-29 Método de produção de uma formulação injetável in vivo de 3he hiperpolarizado, de preparação e de subsequente injeção de 3he gasoso polarizado in vivo, e, de solubilização de 129xe gasoso hiperpolarizado, e, produto hiperpolarizado de fluido farmacêutico injetável in vivo BR9914984A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10684398P 1998-11-03 1998-11-03
PCT/US1999/025434 WO2000025828A1 (en) 1998-11-03 1999-10-29 Hyperpolarized helium-3 microbubble gas entrapment methods

Publications (1)

Publication Number Publication Date
BR9914984A true BR9914984A (pt) 2001-08-14

Family

ID=22313561

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914984-2A BR9914984A (pt) 1998-11-03 1999-10-29 Método de produção de uma formulação injetável in vivo de 3he hiperpolarizado, de preparação e de subsequente injeção de 3he gasoso polarizado in vivo, e, de solubilização de 129xe gasoso hiperpolarizado, e, produto hiperpolarizado de fluido farmacêutico injetável in vivo

Country Status (10)

Country Link
US (3) US6284222B1 (pt)
EP (1) EP1126883A1 (pt)
JP (1) JP2002528520A (pt)
CN (1) CN1337885A (pt)
AU (1) AU1330900A (pt)
BR (1) BR9914984A (pt)
CA (1) CA2348032A1 (pt)
HU (1) HUP0105141A3 (pt)
NO (1) NO20012178L (pt)
WO (1) WO2000025828A1 (pt)

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Also Published As

Publication number Publication date
NO20012178L (no) 2001-07-03
CN1337885A (zh) 2002-02-27
JP2002528520A (ja) 2002-09-03
US20010009658A1 (en) 2001-07-26
US6599497B2 (en) 2003-07-29
NO20012178D0 (no) 2001-05-02
WO2000025828A1 (en) 2000-05-11
US20010051132A1 (en) 2001-12-13
CA2348032A1 (en) 2000-05-11
US6284222B1 (en) 2001-09-04
HUP0105141A2 (hu) 2002-04-29
US6488910B2 (en) 2002-12-03
AU1330900A (en) 2000-05-22
EP1126883A1 (en) 2001-08-29
HUP0105141A3 (en) 2004-04-28

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Legal Events

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FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]