BR9914984A - Método de produção de uma formulação injetável in vivo de 3he hiperpolarizado, de preparação e de subsequente injeção de 3he gasoso polarizado in vivo, e, de solubilização de 129xe gasoso hiperpolarizado, e, produto hiperpolarizado de fluido farmacêutico injetável in vivo - Google Patents
Método de produção de uma formulação injetável in vivo de 3he hiperpolarizado, de preparação e de subsequente injeção de 3he gasoso polarizado in vivo, e, de solubilização de 129xe gasoso hiperpolarizado, e, produto hiperpolarizado de fluido farmacêutico injetável in vivoInfo
- Publication number
- BR9914984A BR9914984A BR9914984-2A BR9914984A BR9914984A BR 9914984 A BR9914984 A BR 9914984A BR 9914984 A BR9914984 A BR 9914984A BR 9914984 A BR9914984 A BR 9914984A
- Authority
- BR
- Brazil
- Prior art keywords
- hyperous
- vivo
- hyperpolarized
- gaseous
- injectable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
"MéTODO DE PRODUçãO DE UMA FORMULAçãO INJETáVEL IN VIVO DE ^ 3^HE HIPERPOLARIZADO, DE PREPARAçãO E DE SUBSEQuENTE INJEçãO DE ^ 3^HE GASOSO POLARIZADO IN VIVO, E, DE SOLUBILIZAçãO DE ^ 129^XE GASOSO HIPERPOLARIZADO, E, PRODUTO HIPERPOLARIZADO DE FLUIDO FARMACêUTICO INJETáVEL IN VIVO" Processos para o aumento da T~ 1~ de formulações de microbolhas injetáveis de ^ 3^He hiperpolarizado incluem a etapa de introduzir o ^ 3^He hiperpolarizado em uma quantidade de microbolhas mantidas dentro de uma câmara e de aumentar a pressão dentro da mesma para facilitar o movimento ou o carregamento do ^ 3^He para dentro das microbolhas. Subsq³entemente, uma quantidade limitada de um líquido transportador ou de uma solução líquida transportadora sozinha, ou pré-misturada com ^ 3^He, pode ser introduzida na microbolha/^ 3^He dentro da câmara para inibir a tendência de o ^ 3^He vazar para fora da bolha. Produtos farmacêuticos relacionados e recipientes associados bem como um processo baseado em evacuação para a rápida misturação e distribuição das bolhas e do ^ 3^He também são descritos. Um processo adicional para dissolução de gás ^ 129^Xe por meio do uso de bolhas como um agente acelerador também é descrito.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10684398P | 1998-11-03 | 1998-11-03 | |
PCT/US1999/025434 WO2000025828A1 (en) | 1998-11-03 | 1999-10-29 | Hyperpolarized helium-3 microbubble gas entrapment methods |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914984A true BR9914984A (pt) | 2001-08-14 |
Family
ID=22313561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914984-2A BR9914984A (pt) | 1998-11-03 | 1999-10-29 | Método de produção de uma formulação injetável in vivo de 3he hiperpolarizado, de preparação e de subsequente injeção de 3he gasoso polarizado in vivo, e, de solubilização de 129xe gasoso hiperpolarizado, e, produto hiperpolarizado de fluido farmacêutico injetável in vivo |
Country Status (10)
Country | Link |
---|---|
US (3) | US6284222B1 (pt) |
EP (1) | EP1126883A1 (pt) |
JP (1) | JP2002528520A (pt) |
CN (1) | CN1337885A (pt) |
AU (1) | AU1330900A (pt) |
BR (1) | BR9914984A (pt) |
CA (1) | CA2348032A1 (pt) |
HU (1) | HUP0105141A3 (pt) |
NO (1) | NO20012178L (pt) |
WO (1) | WO2000025828A1 (pt) |
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BR9711082A (pt) | 1996-03-29 | 2000-01-11 | Lawrence Berkeley National Lab | Realce de rmn emri na presença de gases mopbres hiperpolarizados. |
DE19742548C2 (de) * | 1997-09-26 | 1999-10-07 | Otten Ernst Wilhelm | Magneteinrichtung für Tansport und Aufbewahrung kernspinpolarisierter Gase und Verfahren zur Entnahme dieser Gase |
EP1118009A1 (en) * | 1998-09-28 | 2001-07-25 | Nycomed Imaging As | Method of magnetic resonance imaging |
US6523356B2 (en) | 1998-09-30 | 2003-02-25 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
US6284222B1 (en) | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
US7061237B2 (en) | 2000-07-13 | 2006-06-13 | The Regents Of The University Of California | Remote NMR/MRI detection of laser polarized gases |
US6652833B2 (en) * | 2000-07-13 | 2003-11-25 | The Regents Of The University Of California | Functionalized active-nucleus complex sensor |
WO2002085417A2 (en) * | 2001-04-24 | 2002-10-31 | Medi-Physics, Inc. | Methods and devices for moisturizing hyperpolarized noble gases and pharmaceutical products thereof |
GB0122270D0 (en) * | 2001-09-14 | 2001-11-07 | Secretary Trade Ind Brit | Measurement of the polaristion of a gas |
CA2478466C (en) | 2002-02-06 | 2013-09-17 | The Regents Of The University Of California | Squid detected nmr and mri at ultralow fields |
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DE102005017927A1 (de) * | 2005-04-18 | 2006-10-26 | Forschungszentrum Jülich GmbH | Hyperpolarisation von Li und weiteren Kernen |
DE102005026604A1 (de) * | 2005-06-09 | 2006-12-14 | Membrana Gmbh | Verfahren zum Lösen von Gasen mit kurzlebigen physikalischen Eigenschaften in einer Flüssigkeit |
US8377419B2 (en) * | 2005-09-28 | 2013-02-19 | The President And Fellows Of Harvard College | Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging |
AU2006326596A1 (en) * | 2005-12-10 | 2007-06-21 | The President And Fellows Of Harvard College | In situ hyperpolarization of imaging agents |
US20090252686A1 (en) * | 2006-01-11 | 2009-10-08 | President And Fellows Of Harvard College | Ex Vivo Hyperpolarization of Imaging Agents |
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WO2009143368A2 (en) * | 2008-05-23 | 2009-11-26 | University Of Utah | Non-cryogenic storage cell for hyperpolarized 129xe |
US9289518B2 (en) * | 2008-08-22 | 2016-03-22 | The Brigham And Women's Hospital | Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE |
US20100092390A1 (en) * | 2008-10-09 | 2010-04-15 | President And Fellows Of Harvard College | Methods for Making Particles Having Long Spin-Lattice Relaxation Times |
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US8905992B2 (en) | 2011-11-07 | 2014-12-09 | General Electric Company | Portable microbubble and drug mixing device |
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-
1999
- 1999-10-28 US US09/428,814 patent/US6284222B1/en not_active Expired - Fee Related
- 1999-10-29 JP JP2000579266A patent/JP2002528520A/ja active Pending
- 1999-10-29 EP EP99956775A patent/EP1126883A1/en not_active Withdrawn
- 1999-10-29 BR BR9914984-2A patent/BR9914984A/pt not_active Application Discontinuation
- 1999-10-29 CA CA002348032A patent/CA2348032A1/en not_active Abandoned
- 1999-10-29 AU AU13309/00A patent/AU1330900A/en not_active Abandoned
- 1999-10-29 HU HU0105141A patent/HUP0105141A3/hu unknown
- 1999-10-29 CN CN99815356.7A patent/CN1337885A/zh active Pending
- 1999-10-29 WO PCT/US1999/025434 patent/WO2000025828A1/en not_active Application Discontinuation
-
2001
- 2001-01-19 US US09/766,517 patent/US6488910B2/en not_active Expired - Fee Related
- 2001-05-02 NO NO20012178A patent/NO20012178L/no not_active Application Discontinuation
- 2001-06-28 US US09/894,768 patent/US6599497B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO20012178L (no) | 2001-07-03 |
CN1337885A (zh) | 2002-02-27 |
JP2002528520A (ja) | 2002-09-03 |
US20010009658A1 (en) | 2001-07-26 |
US6599497B2 (en) | 2003-07-29 |
NO20012178D0 (no) | 2001-05-02 |
WO2000025828A1 (en) | 2000-05-11 |
US20010051132A1 (en) | 2001-12-13 |
CA2348032A1 (en) | 2000-05-11 |
US6284222B1 (en) | 2001-09-04 |
HUP0105141A2 (hu) | 2002-04-29 |
US6488910B2 (en) | 2002-12-03 |
AU1330900A (en) | 2000-05-22 |
EP1126883A1 (en) | 2001-08-29 |
HUP0105141A3 (en) | 2004-04-28 |
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