HUP0105141A2 - Eljárás hiperpolarizálható 3He mikrobuborék gázcsapda előállítására és a kapcsolódó termékek - Google Patents

Eljárás hiperpolarizálható 3He mikrobuborék gázcsapda előállítására és a kapcsolódó termékek

Info

Publication number
HUP0105141A2
HUP0105141A2 HU0105141A HUP0105141A HUP0105141A2 HU P0105141 A2 HUP0105141 A2 HU P0105141A2 HU 0105141 A HU0105141 A HU 0105141A HU P0105141 A HUP0105141 A HU P0105141A HU P0105141 A2 HUP0105141 A2 HU P0105141A2
Authority
HU
Hungary
Prior art keywords
hyperpolarized
microbubbles
chamber
preparation
vivo
Prior art date
Application number
HU0105141A
Other languages
English (en)
Inventor
Bastiaan Driehuys
Original Assignee
Medi-Physics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medi-Physics, Inc. filed Critical Medi-Physics, Inc.
Publication of HUP0105141A2 publication Critical patent/HUP0105141A2/hu
Publication of HUP0105141A3 publication Critical patent/HUP0105141A3/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A tal lm ny t rgy t injekt lható, in vivo alkalmazható hiperpolariz lt3He készítmény elő llít s ra szolg ló, in vivo injekt l sra szolg lópolariz lt, g z halmaz llapotú 3He elő llít s hoz kapcsolódó, valamintg z halmaz llapotú, hiperpolariz lt 129Xe felold s ra szolg ló elj rsok képezik. Az in vivo alkalmazható hiperpolariz lt 3He készítményelő llít s ra szolg ló elj r s szerint a mikrobuborékokat (10) kamr babevezetik; a mikrobuborékokat (10) tartalmazó kamr ba hiperpolariz lt3He-t vezetnek; a hiperpolariz lt 3He és a mikrobuborékok (10) kamrban való elhelyezését k"vetően a kamr ba folyadékot (40) vezetnek; akamr ban a nyom st legal bb 105 Pa-ra n"velik; tov bb amikrobuborékokat (10) és a hiperpolariz lt 3He-t a folyadékkal (40)érintkezésbe hozva injekt lható, mikrobuborékos hiperpolariz lt 3Hekészítményt llítanak elő, ahol a folyadékot (40) az injekt lhatókészítmény T1 relax ciós idejét elegendően hosszúv tevőnek v laszj k.Az in vivo injekt l sra szolg ló polariz lt, g z halmaz llapotú 3Heelő llít s hoz kapcsolódó elj r s értelmébe a mikrobuborékokat (10) trolóeszk"zbe (30) vezetik; a t rolóeszk"zt (30) v kuum al helyezik; amikrobuborékokat (10) tartalmazó légtelenített t rolóeszk"zbe (30)hiperpolariz lt 3He g z első mennyiségét bevezetik; és a trolóeszk"zbe (30) fluidum m sodik mennyiségét bevezetve mikrobuborékosoldatot llítanak elő, ahol a fluidumot az oldat T1 relax ciós idejételegendően hosszúv tevőnek v lasztj k, tov bb ahol a mikrobuborékosoldatot vizsg lati alanyba in vivo injekt l sra szolg lón formul zz k.A hiperpolariz lt 129Xe felold s ra szolg ló elj r s keretébenmikrobuborékok (10) első mennyiségét kamr ba vezetik; a hiperpolarizlt 129Xe m sodik mennyiségét a kamr ba vezetik, ahol annak legal bbegy részét a mikrobuborékokkal (10) érintkezésbe hozz k; a 129Xe egyrészét feloldj k; és vizsg lati alanyba juttat st megelőzően amikrobuborékokat (10) a 129Xe-től lényegében teljes egészében elvlasztj k. Ó
HU0105141A 1998-11-03 1999-10-29 Hyperpolarized helium-3 microbubble gas entrapment methods and associated products HUP0105141A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10684398P 1998-11-03 1998-11-03
PCT/US1999/025434 WO2000025828A1 (en) 1998-11-03 1999-10-29 Hyperpolarized helium-3 microbubble gas entrapment methods

Publications (2)

Publication Number Publication Date
HUP0105141A2 true HUP0105141A2 (hu) 2002-04-29
HUP0105141A3 HUP0105141A3 (en) 2004-04-28

Family

ID=22313561

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105141A HUP0105141A3 (en) 1998-11-03 1999-10-29 Hyperpolarized helium-3 microbubble gas entrapment methods and associated products

Country Status (10)

Country Link
US (3) US6284222B1 (hu)
EP (1) EP1126883A1 (hu)
JP (1) JP2002528520A (hu)
CN (1) CN1337885A (hu)
AU (1) AU1330900A (hu)
BR (1) BR9914984A (hu)
CA (1) CA2348032A1 (hu)
HU (1) HUP0105141A3 (hu)
NO (1) NO20012178L (hu)
WO (1) WO2000025828A1 (hu)

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Also Published As

Publication number Publication date
CA2348032A1 (en) 2000-05-11
US6488910B2 (en) 2002-12-03
US20010051132A1 (en) 2001-12-13
NO20012178L (no) 2001-07-03
CN1337885A (zh) 2002-02-27
US6599497B2 (en) 2003-07-29
JP2002528520A (ja) 2002-09-03
NO20012178D0 (no) 2001-05-02
US20010009658A1 (en) 2001-07-26
AU1330900A (en) 2000-05-22
WO2000025828A1 (en) 2000-05-11
US6284222B1 (en) 2001-09-04
EP1126883A1 (en) 2001-08-29
BR9914984A (pt) 2001-08-14
HUP0105141A3 (en) 2004-04-28

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