BR9913643A - Transgênese de mamìferos através de injeção intracitoplásmica de espermatozóides - Google Patents

Transgênese de mamìferos através de injeção intracitoplásmica de espermatozóides

Info

Publication number
BR9913643A
BR9913643A BR9913643-0A BR9913643A BR9913643A BR 9913643 A BR9913643 A BR 9913643A BR 9913643 A BR9913643 A BR 9913643A BR 9913643 A BR9913643 A BR 9913643A
Authority
BR
Brazil
Prior art keywords
injection
transgenesis
mammals
transgene
nucleic acid
Prior art date
Application number
BR9913643-0A
Other languages
English (en)
Inventor
Ryuzo Yanagimachi
Original Assignee
Univ Hawaii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hawaii filed Critical Univ Hawaii
Publication of BR9913643A publication Critical patent/BR9913643A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0335—Genetically modified worms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0337—Genetically modified Arthropods
    • A01K67/0338—Genetically modified Crustaceans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"TRANSGêNESE DE MAMìFEROS ATRAVéS DE INJEçãO INTRACITOPLáSMICA DE ESPERMATOZóIDES"<D>. A coinjeção de oócitos de camundongo infertilizado com cabeças de espermatozóides e ácido nucléico exógeno codificando um transgene resulta em embriões expressando o transgene , refletindo a associação ácido nucléico-cabeça de espermatozóide antes da coinjeção. A transferência não seletiva para mães substitutas dos embriões resultantes da coinjeção produziu descendências expressando o transgene integrado.
BR9913643-0A 1998-08-11 1999-08-10 Transgênese de mamìferos através de injeção intracitoplásmica de espermatozóides BR9913643A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9607898P 1998-08-11 1998-08-11
US13397099P 1999-05-13 1999-05-13
PCT/US1999/018118 WO2000009674A1 (en) 1998-08-11 1999-08-10 Mammalian transgenesis by intracytoplasmic sperm injection

Publications (1)

Publication Number Publication Date
BR9913643A true BR9913643A (pt) 2001-09-25

Family

ID=26791039

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913643-0A BR9913643A (pt) 1998-08-11 1999-08-10 Transgênese de mamìferos através de injeção intracitoplásmica de espermatozóides

Country Status (16)

Country Link
US (1) US6376743B1 (pt)
EP (1) EP1105469B1 (pt)
JP (1) JP3830760B2 (pt)
CN (1) CN1334870A (pt)
AT (1) ATE483017T1 (pt)
AU (1) AU772190B2 (pt)
BR (1) BR9913643A (pt)
CA (1) CA2340199A1 (pt)
DE (1) DE69942804D1 (pt)
DK (1) DK1105469T3 (pt)
HK (1) HK1044174A1 (pt)
IL (1) IL141309A0 (pt)
MX (1) MXPA01001389A (pt)
NZ (1) NZ509634A (pt)
RU (1) RU2267270C2 (pt)
WO (1) WO2000009674A1 (pt)

Families Citing this family (45)

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US20030079240A1 (en) * 1997-12-18 2003-04-24 Newman Stuart A. Chimeric embryos and animals containing human cells
US7241617B2 (en) * 1998-07-03 2007-07-10 Dnavec Research, Inc. Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci
US20040088748A1 (en) * 1999-05-13 2004-05-06 Perry Anthony C.F. Method of performing transgenesis
AU2103601A (en) * 1999-12-17 2001-06-25 Oregon Health And Science University Methods for producing transgenic animals
US20020045156A1 (en) * 2000-05-16 2002-04-18 Mehmet Toner Microinjection of cryoprotectants for preservation of cells
US7094601B2 (en) * 2000-05-16 2006-08-22 The General Hospital Corporation Microinjection of cryoprotectants for preservation of cells
US20040040051A1 (en) * 2001-01-19 2004-02-26 Whitehead Institute For Biomedical Research Generation of non-human mammals by nuclear cloning
US20020116732A1 (en) * 2001-02-13 2002-08-22 Leandro Christmann Microinjection assembly and methods for microinjecting and reimplanting avian eggs
US7339090B2 (en) 2001-02-13 2008-03-04 Avigenics, Inc. Microinjection devices and methods of use
US20080124787A1 (en) * 2001-02-13 2008-05-29 Avigenics, Inc. Microinjection devices and methods of use
US7550650B2 (en) 2001-09-18 2009-06-23 Synageva Biopharma Corp. Production of a transgenic avian by cytoplasmic injection
WO2003025146A2 (en) 2001-09-18 2003-03-27 Avigenics, Inc. Production of a transgenic avian by cytoplasmic injection
US20040210955A1 (en) * 2001-10-26 2004-10-21 Hidenori Akutsu Preparation of spermatozoa for ICSI-mediated transgenesis and methods of using the same
US20040006157A1 (en) * 2002-04-26 2004-01-08 Gloster Daniel F. Ultra violet curable 100 percent solids inks
US7527966B2 (en) * 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
US20040235011A1 (en) * 2002-06-26 2004-11-25 Cooper Richard K. Production of multimeric proteins
US20040172667A1 (en) * 2002-06-26 2004-09-02 Cooper Richard K. Administration of transposon-based vectors to reproductive organs
WO2005062881A2 (en) 2003-12-24 2005-07-14 Transgenrx, Inc. Gene therapy using transposon-based vectors
US20070087008A1 (en) 2004-02-24 2007-04-19 The Government Of The United States Of America As Rab9a, rab11a, and modulators thereof related to infectious disease
ES2245591B1 (es) * 2004-04-06 2007-04-01 Consejo Sup. Investigaciones Cientificas Nuevo procedimiento para generar animales transgenicos no humanos, y los animales transgenicos asi obtenidos.
US20060294606A1 (en) * 2004-05-18 2006-12-28 Istefo Moisyadi Tn5 transposase-mediated transgenesis
NZ554824A (en) 2004-10-22 2010-10-29 Revivicor Inc Porcines that lack endogenous antibody chains and express exogenous immunoglobulins
US7964346B2 (en) 2004-10-27 2011-06-21 Rubin Donald H Mammalian genes involved in infection
NZ565711A (en) 2005-08-09 2011-10-28 Revivicor Inc Transgenic ungulates expressing a porcine CTLA4 peptide fused to an immunoglobulin
EP2173342A2 (en) 2007-06-22 2010-04-14 ETH Zurich Antivirals
US9157097B2 (en) * 2008-09-25 2015-10-13 Proteovec Holding, L.L.C. Vectors for production of growth hormone
US9150880B2 (en) * 2008-09-25 2015-10-06 Proteovec Holding, L.L.C. Vectors for production of antibodies
EP2342224A2 (en) * 2008-09-25 2011-07-13 TransGenRx, Inc. Novel vectors for production of interferon
WO2010051288A1 (en) 2008-10-27 2010-05-06 Revivicor, Inc. Immunocompromised ungulates
WO2010118360A1 (en) * 2009-04-09 2010-10-14 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Production of proteins using transposon-based vectors
WO2010144611A2 (en) * 2009-06-10 2010-12-16 3-V Biosciences, Inc. Antivirals that target transporters, carriers, and ion channels
US10202615B2 (en) 2010-12-10 2019-02-12 Vanderbilt University Mammalian genes involved in toxicity and infection
NZ759163A (en) 2011-02-14 2023-03-31 Revivicor Inc Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
US20150024497A1 (en) * 2013-07-19 2015-01-22 Elwha Llc Methods and Systems for Utilizing Sperm for Molecular Delivery
US20150025306A1 (en) * 2013-07-19 2015-01-22 Elwha Llc Methods and Systems for Utilizing Sperm for Molecular Delivery
RU2613788C1 (ru) * 2015-12-15 2017-03-21 Федеральное государственное бюджетное учреждение "Научный центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации Метод биопсии клеток трофобласта при множественных клетках, не участвующих в компактизации на стадии бластоцисты в программах преимплантационного генетического скрининга эмбрионов человека
CA3031252A1 (en) 2016-07-21 2018-01-25 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
WO2019113743A1 (zh) * 2017-12-11 2019-06-20 清华大学 基因改造方法
KR102036723B1 (ko) 2018-02-09 2019-11-26 재단법인 대구경북과학기술원 세포질내 정자 주입 시스템 및 이를 이용한 정자 주입 방법
CN114667141A (zh) 2019-09-03 2022-06-24 奥布赛瓦股份公司 用于促进胚胎移植和预防流产的催产素拮抗剂给药方案
WO2021160597A1 (en) 2020-02-10 2021-08-19 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy
WO2023250101A1 (en) 2022-06-22 2023-12-28 Gameto, Inc. Compositions and methods for inducing oocyte maturation
US11744920B1 (en) 2022-08-12 2023-09-05 Gameto, Inc Implant for ovarian decline and methods of manufacturing an implant for ovarian decline
WO2024054644A2 (en) 2022-09-09 2024-03-14 Gameto, Inc. Production and applications of ovarian and uterine organoids
WO2024206245A1 (en) 2023-03-24 2024-10-03 Gameto, Inc. Methods and compositions for producing ovarian support cell co-culture

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
US6641526B1 (en) * 1998-03-20 2003-11-04 University Of Hawaii Development of normal offspring from oocytes injected with freeze-dried spermatozoa
CN1316878A (zh) 1998-08-11 2001-10-10 安东尼C·F·佩里 进行转基因的方法

Also Published As

Publication number Publication date
US6376743B1 (en) 2002-04-23
EP1105469A4 (en) 2004-03-10
NZ509634A (en) 2003-10-31
HK1044174A1 (zh) 2002-10-11
CA2340199A1 (en) 2000-02-24
WO2000009674A1 (en) 2000-02-24
JP2003521868A (ja) 2003-07-22
RU2267270C2 (ru) 2006-01-10
JP3830760B2 (ja) 2006-10-11
MXPA01001389A (es) 2004-01-29
IL141309A0 (en) 2002-03-10
AU772190B2 (en) 2004-04-08
DK1105469T3 (da) 2010-12-20
EP1105469B1 (en) 2010-09-29
DE69942804D1 (de) 2010-11-11
CN1334870A (zh) 2002-02-06
ATE483017T1 (de) 2010-10-15
AU5475299A (en) 2000-03-06
EP1105469A1 (en) 2001-06-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008 POR TER SIDO INCORRETO.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1971 DE 14/10/2008.