BR9910674A - Derivados de primidin-aminometil-piridina, seu preparo e seu uso no controle de bactérias helicobacter - Google Patents
Derivados de primidin-aminometil-piridina, seu preparo e seu uso no controle de bactérias helicobacterInfo
- Publication number
- BR9910674A BR9910674A BR9910674-4A BR9910674A BR9910674A BR 9910674 A BR9910674 A BR 9910674A BR 9910674 A BR9910674 A BR 9910674A BR 9910674 A BR9910674 A BR 9910674A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- pyrimidine
- radical
- hydrogen
- control
- Prior art date
Links
- 241000589989 Helicobacter Species 0.000 title abstract 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 abstract 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 abstract 1
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 abstract 1
- MJQSRSOTRPMVKB-UHFFFAOYSA-N 5h-imidazo[4,5-c]pyridazine Chemical compound C1=NNC2=NC=NC2=C1 MJQSRSOTRPMVKB-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 abstract 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 abstract 1
- XWMXMWHHTIEXRE-UHFFFAOYSA-N thiadiazole 1-oxide Chemical compound O=S1C=CN=N1 XWMXMWHHTIEXRE-UHFFFAOYSA-N 0.000 abstract 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Patente de Invenção: <B>"DERIVADOS DE PIRIMIDIN-AMINOMETIL-PIRIDINA, SEU PREPARO E SEU USO NO CONTROLE DE BACTéRIAS HELICOBACTER"<D>. Compostos da fórmula (I) na qual R1, R2 e R3 são hidrogênio, C1-4 alquila ou halogênio, R4, R5, R6 e R9 são hidrogênio ou C1-4 alquila, R7 e R8 são hidrogênio, C1-4 alquila, C1-4 alcóxi ou halogênio, A é C1-7 alquileno, C2-7 alquenileno, C3-7 cicloalquileno ou fenileno, G é hidrogênio, hidroxila, C1-7 alquila, C1-4 alquila a qual é completa ou principalmente substituída por flúor, C2-7 alquenila, C3-7 cicloalquila, um radical mono ou di-C1-4 alquilcarbamoíla ou tiocarbamoíla, um radical N-C1-4 alquil-N'-cianoamidino, um radical 1-N-C1-4-alquilamino-2-nitroetileno, um radical N-2-propinil-N'-cianoamidino, um radical aminosulfonilamidino, o radical -N(R10)R11, a parte do composto da fórmula (I) ligada a A (incluindo X e via X), o radical glicopiranosídeo ou um sistema cíclico ou um sistema bicíclico o qual é não substituído ou substituído por R12 e R13 e o qual é selecionado do grupo consistindo em benzeno, naftaleno, furano, tiofeno, pirrol, oxazol, oxazolina, oxazolidinona, isoxazol, tiazol, tiazolina, isotiazol, imidazol, imidazolina, pirazol, triazol, tetrazol, tiadiazol, 1-óxido de tiadiazol, oxadiazol, piridina, N-óxido de piridina, pirimidina, halopirimidina, piperidina, triazina, piridona, benzimidazol, imidazopiridina, benzotiazol, benzoxazol, quinolina e imidazopiridazina, X é O (oxigênio), N-C1-4 alquila, NH ou S, Y é O (oxigênio), N-C1-4 alquila, NH, S, 1,4-piperazinileno ou 1,4-piperidinileno, Z é O (oxigênio), N-C1-4 alquila, NH ou S ou CO, m é um número de 1 a 7, n é um número de 0 a 4, t é o número 0, 1 ou 2 e u é o número 0 ou 1 e seus sais, são adequados para o controle de bactérias Helicobacter.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98109408 | 1998-05-23 | ||
PCT/EP1999/003477 WO1999061439A1 (en) | 1998-05-23 | 1999-05-20 | Pyrimidin-aminomethyl-pyridine derivatives, their preparation and their use in the control of helicobacter bacteria |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9910674A true BR9910674A (pt) | 2001-01-30 |
Family
ID=8231991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9910674-4A BR9910674A (pt) | 1998-05-23 | 1999-05-20 | Derivados de primidin-aminometil-piridina, seu preparo e seu uso no controle de bactérias helicobacter |
Country Status (23)
Country | Link |
---|---|
US (1) | US6395732B1 (pt) |
EP (1) | EP1091957B1 (pt) |
JP (1) | JP2002516324A (pt) |
KR (1) | KR20010025095A (pt) |
CN (1) | CN1302297A (pt) |
AT (1) | ATE284880T1 (pt) |
AU (1) | AU759629B2 (pt) |
BR (1) | BR9910674A (pt) |
CA (1) | CA2332932A1 (pt) |
DE (1) | DE69922655T2 (pt) |
DK (1) | DK1091957T3 (pt) |
EA (1) | EA003553B1 (pt) |
ES (1) | ES2234261T3 (pt) |
HK (1) | HK1036067A1 (pt) |
HU (1) | HUP0102409A3 (pt) |
IL (1) | IL139530A0 (pt) |
NZ (1) | NZ508170A (pt) |
PL (1) | PL345271A1 (pt) |
PT (1) | PT1091957E (pt) |
SI (1) | SI1091957T1 (pt) |
TR (1) | TR200003451T2 (pt) |
WO (1) | WO1999061439A1 (pt) |
ZA (1) | ZA200006633B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6479514B1 (en) | 1998-05-23 | 2002-11-12 | Altana Pharma Ag | Quinoline-aminomethyl-pyridyl derivatives with anti-helicobacter activity |
AR035967A1 (es) * | 2001-05-18 | 2004-07-28 | Altana Pharma Ag | Un compuesto de piridilmetilaminopirimidina, un medicamento que lo comprende y el uso del mismo |
AR035966A1 (es) | 2001-05-18 | 2004-07-28 | Altana Pharma Ag | Un compuesto de bencilaminopirimidina, un medicamento que lo comprende y el uso del mismo |
WO2003077656A1 (en) | 2002-03-15 | 2003-09-25 | Ciba Specialty Chemicals Holding Inc. | 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces |
US7910592B2 (en) * | 2005-12-30 | 2011-03-22 | Merck Sharp & Dohme Corp. | CETP inhibitors |
US8931778B2 (en) * | 2013-03-15 | 2015-01-13 | Critsuccess Llc | Functional jewelry |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0264883A3 (en) * | 1986-10-21 | 1990-04-04 | Banyu Pharmaceutical Co., Ltd. | Substituted pyridine derivatives |
JPH0812671A (ja) | 1994-06-30 | 1996-01-16 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物 |
NZ290422A (en) | 1994-07-20 | 1999-02-25 | Byk Gulden Lomberg Chem Fab | Pyridyl or pyrimidinyl substituted thiopyridine derivatives and medicaments |
AU2042897A (en) * | 1996-03-21 | 1997-10-10 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives |
-
1999
- 1999-05-20 EP EP99926348A patent/EP1091957B1/en not_active Expired - Lifetime
- 1999-05-20 NZ NZ508170A patent/NZ508170A/en unknown
- 1999-05-20 JP JP2000550845A patent/JP2002516324A/ja active Pending
- 1999-05-20 HU HU0102409A patent/HUP0102409A3/hu unknown
- 1999-05-20 ES ES99926348T patent/ES2234261T3/es not_active Expired - Lifetime
- 1999-05-20 DK DK99926348T patent/DK1091957T3/da active
- 1999-05-20 CN CN99806530A patent/CN1302297A/zh active Pending
- 1999-05-20 AU AU43645/99A patent/AU759629B2/en not_active Ceased
- 1999-05-20 CA CA002332932A patent/CA2332932A1/en not_active Abandoned
- 1999-05-20 PT PT99926348T patent/PT1091957E/pt unknown
- 1999-05-20 IL IL13953099A patent/IL139530A0/xx unknown
- 1999-05-20 SI SI9930751T patent/SI1091957T1/xx unknown
- 1999-05-20 DE DE69922655T patent/DE69922655T2/de not_active Expired - Fee Related
- 1999-05-20 AT AT99926348T patent/ATE284880T1/de not_active IP Right Cessation
- 1999-05-20 KR KR1020007013165A patent/KR20010025095A/ko not_active Application Discontinuation
- 1999-05-20 EA EA200001230A patent/EA003553B1/ru not_active IP Right Cessation
- 1999-05-20 BR BR9910674-4A patent/BR9910674A/pt not_active IP Right Cessation
- 1999-05-20 WO PCT/EP1999/003477 patent/WO1999061439A1/en active IP Right Grant
- 1999-05-20 US US09/700,681 patent/US6395732B1/en not_active Expired - Fee Related
- 1999-05-20 PL PL99345271A patent/PL345271A1/xx not_active Application Discontinuation
- 1999-05-20 TR TR2000/03451T patent/TR200003451T2/xx unknown
-
2000
- 2000-11-15 ZA ZA200006633A patent/ZA200006633B/en unknown
-
2001
- 2001-10-03 HK HK01106942A patent/HK1036067A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PT1091957E (pt) | 2005-05-31 |
NZ508170A (en) | 2003-07-25 |
ES2234261T3 (es) | 2005-06-16 |
DK1091957T3 (da) | 2005-04-11 |
CA2332932A1 (en) | 1999-12-02 |
CN1302297A (zh) | 2001-07-04 |
JP2002516324A (ja) | 2002-06-04 |
DE69922655D1 (de) | 2005-01-20 |
US6395732B1 (en) | 2002-05-28 |
HUP0102409A2 (hu) | 2001-12-28 |
HK1036067A1 (en) | 2001-12-21 |
PL345271A1 (en) | 2001-12-03 |
AU759629B2 (en) | 2003-04-17 |
TR200003451T2 (tr) | 2001-04-20 |
ATE284880T1 (de) | 2005-01-15 |
DE69922655T2 (de) | 2006-03-02 |
KR20010025095A (ko) | 2001-03-26 |
AU4364599A (en) | 1999-12-13 |
EP1091957B1 (en) | 2004-12-15 |
IL139530A0 (en) | 2001-11-25 |
EA003553B1 (ru) | 2003-06-26 |
EP1091957A1 (en) | 2001-04-18 |
EA200001230A1 (ru) | 2001-06-25 |
SI1091957T1 (en) | 2005-06-30 |
HUP0102409A3 (en) | 2003-01-28 |
ZA200006633B (en) | 2001-08-23 |
WO1999061439A1 (en) | 1999-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |