BR9910014A - Processos para a produção de (2s)-2-[(3r)-3-(n-[terc-butiloxicarbonil])-amino)-2-oxopi rrolidin-1-il] propionato de metila e do composto, e, composto - Google Patents

Processos para a produção de (2s)-2-[(3r)-3-(n-[terc-butiloxicarbonil])-amino)-2-oxopi rrolidin-1-il] propionato de metila e do composto, e, composto

Info

Publication number
BR9910014A
BR9910014A BR9910014-2A BR9910014A BR9910014A BR 9910014 A BR9910014 A BR 9910014A BR 9910014 A BR9910014 A BR 9910014A BR 9910014 A BR9910014 A BR 9910014A
Authority
BR
Brazil
Prior art keywords
compound
oxopyrrolidin
butyloxycarbonyl
propionate
tert
Prior art date
Application number
BR9910014-2A
Other languages
English (en)
Inventor
Richard John Brown
Craig Steven Harris
Chiu Wa Leung
Ian Patel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR9910014A publication Critical patent/BR9910014A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

"PROCESSOS PARA A PRODUçãO DE (2<MU>S<MV>)-2-[(3R)-3-(<MU>N<MV>-[<MU>TERC<MV>-BUTIL OXICARBONIL]-AMINO)-2-OXOPIRROLIDIN-1-IL]PROPIONATO DE METILA E DO COMPOSTO, E, COMPOSTO" A invenção diz respeito a um novo processo químico para a produção de (2<MU>S<MV>)-2-[3<MU>R<MV)-3-(<MU>N<MV>-[<MU>terc<MV >-butiloxicarbonil]amino)-2-oxopirrolidin-1-il]-proprionato de metila.
BR9910014-2A 1998-04-29 1999-04-27 Processos para a produção de (2s)-2-[(3r)-3-(n-[terc-butiloxicarbonil])-amino)-2-oxopi rrolidin-1-il] propionato de metila e do composto, e, composto BR9910014A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9809021.0A GB9809021D0 (en) 1998-04-29 1998-04-29 Chemical process
PCT/GB1999/001307 WO1999055669A1 (en) 1998-04-29 1999-04-27 Process for the preparation of methyl(2s)-2-[(3r)-3-(n-[tert-butyloxycarbonyl]-amino)-2-oxopyrrolidin-1-yl]propionate

Publications (1)

Publication Number Publication Date
BR9910014A true BR9910014A (pt) 2001-01-09

Family

ID=10831089

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910014-2A BR9910014A (pt) 1998-04-29 1999-04-27 Processos para a produção de (2s)-2-[(3r)-3-(n-[terc-butiloxicarbonil])-amino)-2-oxopi rrolidin-1-il] propionato de metila e do composto, e, composto

Country Status (16)

Country Link
US (1) US6248903B1 (pt)
EP (1) EP1076645B1 (pt)
JP (1) JP2002513000A (pt)
KR (1) KR20010043046A (pt)
CN (1) CN1298387A (pt)
AT (1) ATE260892T1 (pt)
AU (1) AU3719199A (pt)
BR (1) BR9910014A (pt)
CA (1) CA2327363A1 (pt)
DE (1) DE69915274T2 (pt)
GB (1) GB9809021D0 (pt)
IL (1) IL139310A0 (pt)
NO (1) NO20005410L (pt)
NZ (1) NZ506954A (pt)
WO (1) WO1999055669A1 (pt)
ZA (1) ZA200005302B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130285D0 (en) 2001-12-19 2002-02-06 Astrazeneca Ab Chemical process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723534A (en) 1971-05-28 1973-03-27 Monsanto Co Aryl methyl phenacyl sulfonium tetrafluoroborates
US4377515A (en) 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH
WO1997016425A1 (en) * 1995-10-30 1997-05-09 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
GB9702377D0 (en) 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
WO1997046578A1 (en) 1996-06-07 1997-12-11 Zeneca Limited Peptide derivatives
GB9624562D0 (en) 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives

Also Published As

Publication number Publication date
EP1076645A1 (en) 2001-02-21
ZA200005302B (en) 2001-10-01
DE69915274T2 (de) 2005-02-24
NO20005410D0 (no) 2000-10-27
IL139310A0 (en) 2001-11-25
WO1999055669A1 (en) 1999-11-04
NZ506954A (en) 2003-06-30
GB9809021D0 (en) 1998-06-24
DE69915274D1 (de) 2004-04-08
CN1298387A (zh) 2001-06-06
AU3719199A (en) 1999-11-16
NO20005410L (no) 2000-12-21
US6248903B1 (en) 2001-06-19
KR20010043046A (ko) 2001-05-25
JP2002513000A (ja) 2002-05-08
ATE260892T1 (de) 2004-03-15
EP1076645B1 (en) 2004-03-03
CA2327363A1 (en) 1999-11-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.