BR9907953A - Inibidores de transporte de glicina - Google Patents
Inibidores de transporte de glicinaInfo
- Publication number
- BR9907953A BR9907953A BR9907953-4A BR9907953A BR9907953A BR 9907953 A BR9907953 A BR 9907953A BR 9907953 A BR9907953 A BR 9907953A BR 9907953 A BR9907953 A BR 9907953A
- Authority
- BR
- Brazil
- Prior art keywords
- transport inhibitors
- glycine transport
- transport
- piperidinabutanamides
- glycin
- Prior art date
Links
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/56—Nitrogen atoms
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- C07D223/16—Benzazepines; Hydrogenated benzazepines
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98200700 | 1998-03-06 | ||
PCT/EP1999/001308 WO1999045011A1 (en) | 1998-03-06 | 1999-02-26 | Glycine transport inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9907953A true BR9907953A (pt) | 2000-10-24 |
Family
ID=8233443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9907953-4A BR9907953A (pt) | 1998-03-06 | 1999-02-26 | Inibidores de transporte de glicina |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1058684A1 (hr) |
JP (1) | JP2002505332A (hr) |
KR (1) | KR20010032967A (hr) |
CN (1) | CN1291984A (hr) |
AU (1) | AU3254499A (hr) |
BG (1) | BG104686A (hr) |
BR (1) | BR9907953A (hr) |
CA (1) | CA2322136A1 (hr) |
EE (1) | EE200000483A (hr) |
HR (1) | HRP20000524A2 (hr) |
HU (1) | HUP0101281A3 (hr) |
IL (1) | IL138227A0 (hr) |
NO (1) | NO20004432L (hr) |
PL (1) | PL342818A1 (hr) |
SK (1) | SK13092000A3 (hr) |
TR (1) | TR200002570T2 (hr) |
WO (1) | WO1999045011A1 (hr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA73749C2 (en) * | 1999-11-01 | 2005-09-15 | Diarylenines | |
US20020120149A1 (en) | 2000-09-08 | 2002-08-29 | Ali Syed M. | Substituted hydrazine derivatives |
CA2422044A1 (en) | 2000-09-14 | 2002-03-21 | Gliatech, Inc. | Nitrogen-containing compounds and their use as glycine transport inhibitors |
KR20030043970A (ko) * | 2000-10-12 | 2003-06-02 | 에스에스 세야쿠 가부시키 가이샤 | 2,2-디페닐부탄아미드 유도체 및 이를 함유하는 의약 |
AR032653A1 (es) | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
WO2003082819A1 (fr) * | 2002-04-01 | 2003-10-09 | Nippon Chemiphar Co.,Ltd. | Derive de n-phenyl-n-(4-piperidinyl)amide |
FR2838739B1 (fr) * | 2002-04-19 | 2004-05-28 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique |
US6995168B2 (en) | 2002-05-31 | 2006-02-07 | Euro-Celtique S.A. | Triazaspiro compounds useful for treating or preventing pain |
FR2842805A1 (fr) * | 2002-07-29 | 2004-01-30 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide,leur preparation et leur application et therapeutique |
FR2842804B1 (fr) | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
US7202259B2 (en) | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
BRPI0407543A (pt) | 2003-02-17 | 2006-02-14 | Hoffmann La Roche | derivados de piperidina-benzenossulfonamida |
DK1656361T3 (da) * | 2003-08-11 | 2008-05-05 | Hoffmann La Roche | Piperazin med OR-substitueret phenylgruppe og anvendelse deraf som GLYT1-inhibitorer |
FR2861070B1 (fr) | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique |
FR2861071B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique |
FR2861076B1 (fr) | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
WO2005058317A1 (en) * | 2003-12-18 | 2005-06-30 | Glaxo Group Limited | Glycine transporter-1 inhibirors |
CA2552087C (en) | 2004-01-30 | 2011-01-25 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
GB0408774D0 (en) * | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
DE602005014274D1 (de) | 2004-12-09 | 2009-06-10 | Hoffmann La Roche | Phenylpiperazin-methanon-derivate |
RU2007121768A (ru) * | 2004-12-15 | 2009-01-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Би- и трициклически замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 (glyt-1) для лечения болезни альцгеймера |
US7485637B2 (en) | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
ATE472327T1 (de) | 2005-01-07 | 2010-07-15 | Hoffmann La Roche | Ä4-(heteroaryl)piperazin-1-ylü-(2,5-substituier e phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen |
JP2008527016A (ja) | 2005-01-18 | 2008-07-24 | エフ.ホフマン−ラ ロシュ アーゲー | 神経及び神経精神病の疾患の治療のためのグリシントランスポーター1(GlyT−1)阻害剤としての2,5−二置換フェニルメタノン誘導体 |
CN101146808B (zh) | 2005-01-26 | 2011-10-12 | 弗·哈夫曼-拉罗切有限公司 | 苯甲酮衍生物及其作为甘氨酸转运体1抑制剂的应用 |
DE602006010665D1 (en) | 2005-02-07 | 2010-01-07 | Hoffmann La Roche | Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1 |
AU2006231917B2 (en) | 2005-04-08 | 2011-07-28 | Pfizer Products Inc. | Bicyclic [3.1.0] heteroaryl amides as type I glycine transport inhibitors |
WO2009010479A2 (en) * | 2007-07-13 | 2009-01-22 | Euroscreen S.A. | Heterocyclic methylene piperidine derivatives and their use |
WO2010065701A1 (en) * | 2008-12-04 | 2010-06-10 | Sanofi-Aventis | Novel polymorphic forms of an azabicyclo-trifluoromethyl benzamide derivative |
CN102766080B (zh) * | 2011-05-06 | 2015-09-23 | 上海医药工业研究院 | 一类吡咯烷衍生物、其制备方法及应用 |
KR20130002292A (ko) * | 2011-06-28 | 2013-01-07 | 주식회사 비보존 | 다중 타겟팅의 상승 효과를 유발하는 유효물질의 조합 및 그 용도 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3714159A (en) * | 1971-03-30 | 1973-01-30 | Janssen Pharmaceutica Nv | 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides |
US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
GB8515934D0 (en) * | 1985-06-24 | 1985-07-24 | Janssen Pharmaceutica Nv | (4-piperidinomethyl and-hetero)purines |
CA1332236C (en) * | 1985-10-11 | 1994-10-04 | Lourens Wals | ,--diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, n-oxides |
AU737095B2 (en) * | 1996-05-31 | 2001-08-09 | Nps Pharmaceuticals, Inc. | Pharmaceutical for treating of neurological and neuropsychiatric disorders |
-
1999
- 1999-02-26 AU AU32544/99A patent/AU3254499A/en not_active Abandoned
- 1999-02-26 CN CN99803530A patent/CN1291984A/zh active Pending
- 1999-02-26 TR TR2000/02570T patent/TR200002570T2/xx unknown
- 1999-02-26 SK SK1309-2000A patent/SK13092000A3/sk unknown
- 1999-02-26 IL IL138227??A patent/IL138227A0/xx unknown
- 1999-02-26 PL PL99342818A patent/PL342818A1/xx unknown
- 1999-02-26 KR KR1020007006314A patent/KR20010032967A/ko not_active Application Discontinuation
- 1999-02-26 CA CA002322136A patent/CA2322136A1/en not_active Abandoned
- 1999-02-26 HU HU0101281A patent/HUP0101281A3/hu unknown
- 1999-02-26 JP JP2000534553A patent/JP2002505332A/ja not_active Withdrawn
- 1999-02-26 WO PCT/EP1999/001308 patent/WO1999045011A1/en not_active Application Discontinuation
- 1999-02-26 EP EP99937930A patent/EP1058684A1/en not_active Withdrawn
- 1999-02-26 BR BR9907953-4A patent/BR9907953A/pt not_active Application Discontinuation
- 1999-02-26 EE EEP200000483A patent/EE200000483A/xx unknown
-
2000
- 2000-08-02 HR HR20000524A patent/HRP20000524A2/hr not_active Application Discontinuation
- 2000-08-11 BG BG104686A patent/BG104686A/xx unknown
- 2000-09-05 NO NO20004432A patent/NO20004432L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL342818A1 (en) | 2001-07-02 |
CA2322136A1 (en) | 1999-09-10 |
AU3254499A (en) | 1999-09-20 |
HRP20000524A2 (en) | 2001-02-28 |
BG104686A (en) | 2001-04-30 |
HUP0101281A2 (hu) | 2001-09-28 |
SK13092000A3 (sk) | 2001-03-12 |
TR200002570T2 (tr) | 2000-12-21 |
KR20010032967A (ko) | 2001-04-25 |
EE200000483A (et) | 2002-02-15 |
HUP0101281A3 (en) | 2001-11-28 |
WO1999045011A8 (en) | 1999-10-14 |
CN1291984A (zh) | 2001-04-18 |
NO20004432L (no) | 2000-11-02 |
EP1058684A1 (en) | 2000-12-13 |
WO1999045011A1 (en) | 1999-09-10 |
IL138227A0 (en) | 2001-10-31 |
JP2002505332A (ja) | 2002-02-19 |
NO20004432D0 (no) | 2000-09-05 |
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