BR9816177B1 - processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina. - Google Patents

processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina.

Info

Publication number
BR9816177B1
BR9816177B1 BRPI9816177-6A BR9816177A BR9816177B1 BR 9816177 B1 BR9816177 B1 BR 9816177B1 BR 9816177 A BR9816177 A BR 9816177A BR 9816177 B1 BR9816177 B1 BR 9816177B1
Authority
BR
Brazil
Prior art keywords
preparing
vinflunine
difluorovinblastine
deoxy
formula
Prior art date
Application number
BRPI9816177-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Bridget Hill
Jacques Fahy
Alain Duflos
Boulay Valerie Thillaye Du
Jean-Marc Barret
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR9816177B1 publication Critical patent/BR9816177B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
BRPI9816177-6A 1997-04-10 1998-04-10 processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina. BR9816177B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9704398A FR2761990B1 (fr) 1997-04-10 1997-04-10 Derives halogenes antimitotiques d'alcaloides de vinca

Publications (1)

Publication Number Publication Date
BR9816177B1 true BR9816177B1 (pt) 2010-08-24

Family

ID=9505731

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9816177-6A BR9816177B1 (pt) 1997-04-10 1998-04-10 processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina.
BRPI9807944-1A BR9807944B1 (pt) 1997-04-10 1998-04-10 derivados antimitóticos dos alcalóides da vinca, processo para preparar os mesmos e uso dos derivados.

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI9807944-1A BR9807944B1 (pt) 1997-04-10 1998-04-10 derivados antimitóticos dos alcalóides da vinca, processo para preparar os mesmos e uso dos derivados.

Country Status (15)

Country Link
US (1) US6127377A (https=)
EP (3) EP0975640B1 (https=)
JP (3) JP4401440B2 (https=)
AT (2) ATE270297T1 (https=)
AU (1) AU737549C (https=)
BR (2) BR9816177B1 (https=)
CA (3) CA2455416C (https=)
CY (2) CY1111476T1 (https=)
DE (3) DE69824840T2 (https=)
DK (2) DK1764368T3 (https=)
ES (2) ES2222588T3 (https=)
FR (2) FR2761990B1 (https=)
LU (1) LU91769I2 (https=)
PT (2) PT1764368E (https=)
WO (1) WO1998045301A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
EP1694330A4 (en) * 2003-12-04 2009-06-24 Amr Technology Inc DERIVATIVES OF VINORELBINE
NZ547370A (en) * 2003-12-04 2010-09-30 Amr Technology Inc Vinca derivatives
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
WO2008033935A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
FR2905949B1 (fr) 2006-09-20 2008-11-21 Pierre Fabre Medicament Sa Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
FR2910812B1 (fr) * 2006-12-29 2009-03-20 Pierre Fabre Medicament Sa Compositions pharmaceutiques injectables lyophilisees de derives hemi-synthetiques d'alcaloide de vinca stables a temperature ambiante
FR2912406B1 (fr) 2007-02-13 2009-05-08 Pierre Fabre Medicament Sa Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
US20090076055A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched vinflunine
DE102010020994B4 (de) * 2010-01-27 2022-01-27 Interpane Entwicklungs-Und Beratungsgesellschaft Mbh Verfahren zur Herstellung eines beschichteten Gegenstands mit Texturätzen
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
US8940754B2 (en) 2010-02-22 2015-01-27 The Scripps Research Institute 10′-fluorinated Vinca alkaloids provide enhanced biological activity against MDR cancer cells
WO2026064520A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload
WO2026064527A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca

Also Published As

Publication number Publication date
US6127377A (en) 2000-10-03
BR9807944A (pt) 2000-03-08
CY1111476T1 (el) 2012-01-25
AU737549B2 (en) 2001-08-23
JP4401440B2 (ja) 2010-01-20
JP2004277418A (ja) 2004-10-07
CA2665949A1 (fr) 1998-10-15
JP2009167196A (ja) 2009-07-30
CA2286560A1 (fr) 1998-10-15
FR2761990B1 (fr) 1999-06-25
JP4307292B2 (ja) 2009-08-05
CY2010019I2 (el) 2012-01-25
EP0975640B1 (fr) 2004-06-30
PT1764368E (pt) 2010-09-16
DE69824840D1 (de) 2004-08-05
EP1764368A1 (fr) 2007-03-21
DE69824840T2 (de) 2005-07-21
EP0975640A1 (fr) 2000-02-02
CA2665949C (fr) 2013-06-11
AU7340898A (en) 1998-10-30
PT975640E (pt) 2004-11-30
ES2347878T3 (es) 2010-11-22
JP2001518892A (ja) 2001-10-16
FR10C0045I2 (fr) 2011-04-29
DE122010000054I1 (de) 2011-05-05
CA2455416C (fr) 2010-11-02
LU91769I2 (fr) 2011-02-22
DE69841766D1 (de) 2010-08-26
WO1998045301A1 (fr) 1998-10-15
BR9807944B1 (pt) 2011-02-08
FR10C0045I1 (https=) 2010-10-29
EP1357125A2 (fr) 2003-10-29
AU737549C (en) 2002-03-28
CA2455416A1 (fr) 1998-10-15
ATE270297T1 (de) 2004-07-15
CY2010019I1 (el) 2012-01-25
DK1764368T3 (da) 2010-10-18
DK0975640T3 (da) 2004-11-01
FR2761990A1 (fr) 1998-10-16
CA2286560C (fr) 2009-09-08
ATE473987T1 (de) 2010-07-15
EP1764368B1 (fr) 2010-07-14
EP1357125A3 (fr) 2003-11-26
ES2222588T3 (es) 2005-02-01

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/08/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 24.08.2020