AU737549C - Antimitotic halo derivatives of vinca alkaloids - Google Patents

Antimitotic halo derivatives of vinca alkaloids

Info

Publication number
AU737549C
AU737549C AU73408/98A AU7340898A AU737549C AU 737549 C AU737549 C AU 737549C AU 73408/98 A AU73408/98 A AU 73408/98A AU 7340898 A AU7340898 A AU 7340898A AU 737549 C AU737549 C AU 737549C
Authority
AU
Australia
Prior art keywords
antimitotic
vinca alkaloids
halo derivatives
formula
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU73408/98A
Other languages
English (en)
Other versions
AU7340898A (en
AU737549B2 (en
Inventor
Jean-Marc Barret
Alain Duflos
Jacques Fahy
Bridget Hill
Valerie Thillaye Du Boulay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of AU7340898A publication Critical patent/AU7340898A/en
Publication of AU737549B2 publication Critical patent/AU737549B2/en
Application granted granted Critical
Publication of AU737549C publication Critical patent/AU737549C/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AU73408/98A 1997-04-10 1998-04-10 Antimitotic halo derivatives of vinca alkaloids Expired AU737549C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9704398A FR2761990B1 (fr) 1997-04-10 1997-04-10 Derives halogenes antimitotiques d'alcaloides de vinca
FR97/04398 1997-04-10
PCT/FR1998/000730 WO1998045301A1 (fr) 1997-04-10 1998-04-10 Derives halogenes antimitotiques d'alcaloides de vinca

Publications (3)

Publication Number Publication Date
AU7340898A AU7340898A (en) 1998-10-30
AU737549B2 AU737549B2 (en) 2001-08-23
AU737549C true AU737549C (en) 2002-03-28

Family

ID=9505731

Family Applications (1)

Application Number Title Priority Date Filing Date
AU73408/98A Expired AU737549C (en) 1997-04-10 1998-04-10 Antimitotic halo derivatives of vinca alkaloids

Country Status (15)

Country Link
US (1) US6127377A (https=)
EP (3) EP1357125A3 (https=)
JP (3) JP4401440B2 (https=)
AT (2) ATE270297T1 (https=)
AU (1) AU737549C (https=)
BR (2) BR9807944B1 (https=)
CA (3) CA2455416C (https=)
CY (2) CY1111476T1 (https=)
DE (3) DE69841766D1 (https=)
DK (2) DK1764368T3 (https=)
ES (2) ES2347878T3 (https=)
FR (2) FR2761990B1 (https=)
LU (1) LU91769I2 (https=)
PT (2) PT975640E (https=)
WO (1) WO1998045301A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
WO2005055939A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinca derivatives
WO2005055943A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinorelbine derivatives
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
US7772177B2 (en) 2005-05-18 2010-08-10 Aegera Therapeutics, Inc. BIR domain binding compounds
FR2894966B1 (fr) 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine
AU2007250443B2 (en) 2006-05-16 2013-06-13 Pharmascience Inc. IAP BIR domain binding compounds
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
FR2905949B1 (fr) * 2006-09-20 2008-11-21 Pierre Fabre Medicament Sa Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
FR2910812B1 (fr) 2006-12-29 2009-03-20 Pierre Fabre Medicament Sa Compositions pharmaceutiques injectables lyophilisees de derives hemi-synthetiques d'alcaloide de vinca stables a temperature ambiante
FR2912406B1 (fr) * 2007-02-13 2009-05-08 Pierre Fabre Medicament Sa Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
US20090076055A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched vinflunine
DE102010020994B4 (de) * 2010-01-27 2022-01-27 Interpane Entwicklungs-Und Beratungsgesellschaft Mbh Verfahren zur Herstellung eines beschichteten Gegenstands mit Texturätzen
WO2011098904A1 (en) 2010-02-12 2011-08-18 Aegera Therapeutics, Inc. Iap bir domain binding compounds
WO2011103007A2 (en) * 2010-02-22 2011-08-25 The Scripps Research Institute 10'-fluorinated vinca alkaloids provide enhanced biological activity against mdr cancer cells
WO2026064527A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload
WO2026064520A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707988A1 (fr) * 1993-07-21 1995-01-27 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707988A1 (fr) * 1993-07-21 1995-01-27 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.

Also Published As

Publication number Publication date
CA2455416A1 (fr) 1998-10-15
CA2286560A1 (fr) 1998-10-15
CY1111476T1 (el) 2012-01-25
BR9816177B1 (pt) 2010-08-24
EP1764368A1 (fr) 2007-03-21
FR10C0045I1 (https=) 2010-10-29
CA2665949A1 (fr) 1998-10-15
DK0975640T3 (da) 2004-11-01
CA2455416C (fr) 2010-11-02
EP1764368B1 (fr) 2010-07-14
JP2004277418A (ja) 2004-10-07
DE69824840T2 (de) 2005-07-21
JP4307292B2 (ja) 2009-08-05
CA2665949C (fr) 2013-06-11
CY2010019I2 (el) 2012-01-25
JP2001518892A (ja) 2001-10-16
AU7340898A (en) 1998-10-30
PT1764368E (pt) 2010-09-16
CY2010019I1 (el) 2012-01-25
ATE270297T1 (de) 2004-07-15
ATE473987T1 (de) 2010-07-15
CA2286560C (fr) 2009-09-08
EP1357125A3 (fr) 2003-11-26
LU91769I2 (fr) 2011-02-22
AU737549B2 (en) 2001-08-23
ES2347878T3 (es) 2010-11-22
EP1357125A2 (fr) 2003-10-29
PT975640E (pt) 2004-11-30
JP4401440B2 (ja) 2010-01-20
DE69824840D1 (de) 2004-08-05
EP0975640B1 (fr) 2004-06-30
BR9807944B1 (pt) 2011-02-08
DE69841766D1 (de) 2010-08-26
EP0975640A1 (fr) 2000-02-02
US6127377A (en) 2000-10-03
FR10C0045I2 (fr) 2011-04-29
BR9807944A (pt) 2000-03-08
JP2009167196A (ja) 2009-07-30
DE122010000054I1 (de) 2011-05-05
ES2222588T3 (es) 2005-02-01
DK1764368T3 (da) 2010-10-18
WO1998045301A1 (fr) 1998-10-15
FR2761990A1 (fr) 1998-10-16
FR2761990B1 (fr) 1999-06-25

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Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20010810

FGA Letters patent sealed or granted (standard patent)
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS WAS NOTIFIED IN THE OFFICIAL JOURNAL DATED 20010920