BR9815603A - Tolerância de micotoxinas de tricotecenos em plantas e animais através da modificação do gene de proteìna ribossÈmica l3 - Google Patents

Tolerância de micotoxinas de tricotecenos em plantas e animais através da modificação do gene de proteìna ribossÈmica l3

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Publication number
BR9815603A
BR9815603A BR9815603-9A BR9815603A BR9815603A BR 9815603 A BR9815603 A BR 9815603A BR 9815603 A BR9815603 A BR 9815603A BR 9815603 A BR9815603 A BR 9815603A
Authority
BR
Brazil
Prior art keywords
fusarium
animals
plants
mycotoxins
trichothecene
Prior art date
Application number
BR9815603-9A
Other languages
English (en)
Inventor
Linda J Harris
Stephen C Gledie
John A Simmonds
Original Assignee
Ca Minister Agriculture & Food
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Minister Agriculture & Food filed Critical Ca Minister Agriculture & Food
Publication of BR9815603A publication Critical patent/BR9815603A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8209—Selection, visualisation of transformants, reporter constructs, e.g. antibiotic resistance markers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

TOLERâNCIA DE MICOTOXINAS DE TRICOTECENO EM PLANTAS E ANIMAIS ATRAVéS DA MODIFICAçãO DO GENE DE PROTEìNA RIBOSSÈMICA L3 Fusarium graminearum é um patógeno de planta, que ataca uma faixa ampla de espécies de planta incluindo milho (podridão talo e espiga), cevada e trigo (praga da cabeça, como ferrugem). As pragas de Fusarium resultam em perdas de milhões de dólares nas receitas de colheitas. A infecção por Fusarium graminearum nos cereais reduz tanto o rendimento quanto a qualidade do grão. As micotoxinas são produzidas por muitas espécies fúngicas de Fusarium e assim o grão torna-se contaminado com estas micotoxinas, tais como os tricotecenos. O principal tricoteceno produzido por F. graminearum bem como por F. culmorum é desoxinivalenol (abreviado como DON, também conhecido como vomitoxina). Os tricotecenos são inibidores da síntese protéica potentes e são bastante tóxicos para seres humanos e gado. Um gene de levedura foi identificado o qual é resistente ao tricoteceno, tricodermina. Um gene de planta correspondente foi preparado, o qual tem sido utilizado para transformar plantas e seria adequado para transformar animais. Estas plantas transformadas têm uma tolerância aumentada aos tricotecenos e poderiam ser mais resistentes à infestação por Fusarium. Potencialmente, os animais transformados poderiam ter uma tolerância aumentada às micotoxinas de tricoteceno. O gene modificado também poderia ser utilizado como um marcador selecionável em experiências de transformação.
BR9815603-9A 1997-08-12 1998-07-29 Tolerância de micotoxinas de tricotecenos em plantas e animais através da modificação do gene de proteìna ribossÈmica l3 BR9815603A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/909,828 US6060646A (en) 1997-08-12 1997-08-12 Tolerance of trichothecene mycotoxins in plants and animals through the modification of the peptidyl transferase gene
PCT/CA1998/000733 WO1999009173A1 (en) 1997-08-12 1998-07-29 Tolerance of trichothecene mycotoxins in plants and animals through the modification of the ribosomal protein l3 gene

Publications (1)

Publication Number Publication Date
BR9815603A true BR9815603A (pt) 2001-01-16

Family

ID=25427893

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9815603-9A BR9815603A (pt) 1997-08-12 1998-07-29 Tolerância de micotoxinas de tricotecenos em plantas e animais através da modificação do gene de proteìna ribossÈmica l3

Country Status (9)

Country Link
US (1) US6060646A (pt)
EP (1) EP1003867A1 (pt)
CN (1) CN1268974A (pt)
AR (1) AR016788A1 (pt)
AU (1) AU754959B2 (pt)
BR (1) BR9815603A (pt)
CA (1) CA2300681C (pt)
UY (1) UY25133A1 (pt)
WO (1) WO1999009173A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855872B2 (en) * 1997-08-12 2005-02-15 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Tolerance of trichothecene mycotoxins in plants through the modification of the ribosomal protein L3 gene
WO2000039291A1 (en) * 1998-12-31 2000-07-06 Rutgers, The State University Virus-resistant transgenic plants expressing l3
US6346655B1 (en) * 1999-03-31 2002-02-12 Syngenta Participations Ag Trichothecne-Resistant transgenic plants
DZ3146A1 (fr) * 1999-03-31 2000-10-12 Syngenta Participations Ag Plantes transgéniques et procédés.
AT408442B (de) * 1999-07-19 2001-11-26 Innovationsagentur Gmbh Mutiertes ribosomales protein l3
CN1301747A (zh) * 1999-12-27 2001-07-04 上海博德基因开发有限公司 一种新的多肽——核糖体s19e蛋白10和编码这种多肽的多核苷酸
US20060005271A1 (en) * 2003-12-12 2006-01-05 Rutgers, The State University Transgenic plants expressing L3 delta proteins are resistant to trichothecene fungal toxins
CN1318427C (zh) * 2005-03-21 2007-05-30 中国海洋大学 氢化木霉醇类化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816406A (en) * 1986-07-24 1989-03-28 The United States Of America, As Represented By The Secretary Of Agriculture Inhibition of trichothecene toxins by ancymidol
DE4108746A1 (de) * 1991-03-18 1992-09-24 Lindner Wolfgang Dekontamination und detoxifikation von getreide, welches mit trochothecen-mykotoxinen belastet ist
PT672124E (pt) * 1992-12-07 2002-11-29 Biogemma Fr Utilizacao de uma sequencia de dna codificadora de uma proteina que degrada acido oxalico como gene de seleccao
US5589611A (en) * 1992-12-15 1996-12-31 Pioneer Hi-Bred International, Inc. Disease resistance gene from maize and its use for disease resistance as a selectable marker and as a gene identification probe
US5792931A (en) * 1994-08-12 1998-08-11 Pioneer Hi-Bred International, Inc. Fumonisin detoxification compositions and methods
NZ301911A (en) * 1994-12-30 2000-04-28 Proguard Inc Biocontrol of mycotoxin-producing micro-organisms

Also Published As

Publication number Publication date
AR016788A1 (es) 2001-08-01
UY25133A1 (es) 1998-09-14
CN1268974A (zh) 2000-10-04
EP1003867A1 (en) 2000-05-31
AU8526398A (en) 1999-03-08
AU754959B2 (en) 2002-11-28
CA2300681A1 (en) 1999-02-25
WO1999009173A1 (en) 1999-02-25
US6060646A (en) 2000-05-09
CA2300681C (en) 2007-07-03

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