BR9814142A - Organismo não humano transgênico, célula ou linha de célula do mesmo, método para produzir um mamìfero não humano com uma interrupção dirigida em um gene antagonista receptor da interleucina-1 (il-1rn), construção nocaute de antagonista receptor il-1, construção nocaute il-1rn e método para testar um agente quanto a efetividade contra uma condição inflamatória. - Google Patents
Organismo não humano transgênico, célula ou linha de célula do mesmo, método para produzir um mamìfero não humano com uma interrupção dirigida em um gene antagonista receptor da interleucina-1 (il-1rn), construção nocaute de antagonista receptor il-1, construção nocaute il-1rn e método para testar um agente quanto a efetividade contra uma condição inflamatória.Info
- Publication number
- BR9814142A BR9814142A BR9814142-2A BR9814142A BR9814142A BR 9814142 A BR9814142 A BR 9814142A BR 9814142 A BR9814142 A BR 9814142A BR 9814142 A BR9814142 A BR 9814142A
- Authority
- BR
- Brazil
- Prior art keywords
- antagonist
- interleukin
- knockout
- cell
- human
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000010276 construction Methods 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 230000004968 inflammatory condition Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 229940124084 Interleukin 1 antagonist Drugs 0.000 title 1
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 102000015696 Interleukins Human genes 0.000 abstract 2
- 108010063738 Interleukins Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 abstract 1
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 abstract 1
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000415 inactivating effect Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9723835.6A GB9723835D0 (en) | 1997-11-13 | 1997-11-13 | Interleukin knockout |
PCT/US1998/024287 WO1999025857A2 (en) | 1997-11-13 | 1998-11-13 | Transgenic models of inflammatory disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9814142A true BR9814142A (pt) | 2000-10-03 |
Family
ID=10821919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9814142-2A BR9814142A (pt) | 1997-11-13 | 1998-11-13 | Organismo não humano transgênico, célula ou linha de célula do mesmo, método para produzir um mamìfero não humano com uma interrupção dirigida em um gene antagonista receptor da interleucina-1 (il-1rn), construção nocaute de antagonista receptor il-1, construção nocaute il-1rn e método para testar um agente quanto a efetividade contra uma condição inflamatória. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1030926A2 (ja) |
JP (1) | JP2001523467A (ja) |
KR (1) | KR20010015814A (ja) |
AU (1) | AU1796699A (ja) |
BR (1) | BR9814142A (ja) |
CA (1) | CA2309807A1 (ja) |
GB (1) | GB9723835D0 (ja) |
HU (1) | HUP0004352A2 (ja) |
IL (1) | IL136013A0 (ja) |
NO (1) | NO20002477L (ja) |
PL (1) | PL340829A1 (ja) |
TR (1) | TR200001356T2 (ja) |
WO (1) | WO1999025857A2 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6437216B1 (en) | 1997-11-13 | 2002-08-20 | Interleukin Genetics Inc. | Transgenic models of inflammatory disease |
WO2001056606A1 (fr) * | 2000-01-31 | 2001-08-09 | Santen Pharmaceutical Co., Ltd. | Remedes pour troubles ophtalmiques |
KR20030067204A (ko) * | 2002-02-07 | 2003-08-14 | 한국생명공학연구원 | 퍼록시레독신-ⅱ 유전자 결손 생쥐 및 이의 생산방법 |
EP1723235B1 (en) * | 2004-02-12 | 2012-06-27 | The Walter And Eliza Hall Institute Of Medical Research | Modified cells that co-express blimp1 and a reporter molecule and methods of using the same |
JP2009183176A (ja) * | 2008-02-05 | 2009-08-20 | Univ Of Tokyo | Il−1タイプiiレセプター遺伝子の欠損変異体マウス |
JP5186637B2 (ja) * | 2009-07-30 | 2013-04-17 | 国立大学法人富山大学 | トランスジェニック非ヒト哺乳動物およびその利用 |
WO2019235839A1 (ko) * | 2018-06-05 | 2019-12-12 | 사회복지법인 삼성생명공익재단 | 그레이브스 안병증 표현형 동물 모델, 그의 제조방법 및 그레이브스 안병증 치료물질 스크리닝 방법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1269989B (it) * | 1994-09-21 | 1997-04-16 | Dompe Spa | Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria |
EP0787179A4 (en) * | 1994-10-20 | 1999-05-19 | Merck & Co Inc | TRANSGENIC ANIMALS WITH INTERLEUKIN-1-g (b) DEFICIENCY |
US6210877B1 (en) * | 1997-03-10 | 2001-04-03 | Interleukin Genetics, Inc. | Prediction of coronary artery disease |
-
1997
- 1997-11-13 GB GBGB9723835.6A patent/GB9723835D0/en not_active Ceased
-
1998
- 1998-11-13 TR TR2000/01356T patent/TR200001356T2/xx unknown
- 1998-11-13 CA CA002309807A patent/CA2309807A1/en not_active Abandoned
- 1998-11-13 KR KR1020007005243A patent/KR20010015814A/ko not_active Application Discontinuation
- 1998-11-13 WO PCT/US1998/024287 patent/WO1999025857A2/en not_active Application Discontinuation
- 1998-11-13 PL PL98340829A patent/PL340829A1/xx unknown
- 1998-11-13 HU HU0004352A patent/HUP0004352A2/hu unknown
- 1998-11-13 EP EP98962809A patent/EP1030926A2/en not_active Withdrawn
- 1998-11-13 AU AU17966/99A patent/AU1796699A/en not_active Abandoned
- 1998-11-13 JP JP2000521220A patent/JP2001523467A/ja active Pending
- 1998-11-13 IL IL13601398A patent/IL136013A0/xx unknown
- 1998-11-13 BR BR9814142-2A patent/BR9814142A/pt not_active Application Discontinuation
-
2000
- 2000-05-12 NO NO20002477A patent/NO20002477L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TR200001356T2 (tr) | 2000-08-21 |
AU1796699A (en) | 1999-06-07 |
NO20002477L (no) | 2000-07-12 |
NO20002477D0 (no) | 2000-05-12 |
HUP0004352A2 (en) | 2001-03-28 |
KR20010015814A (ko) | 2001-02-26 |
PL340829A1 (en) | 2001-02-26 |
WO1999025857A3 (en) | 1999-07-15 |
JP2001523467A (ja) | 2001-11-27 |
CA2309807A1 (en) | 1999-05-27 |
EP1030926A2 (en) | 2000-08-30 |
WO1999025857A2 (en) | 1999-05-27 |
IL136013A0 (en) | 2001-05-20 |
GB9723835D0 (en) | 1998-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |