BR9812752A - Derivados de 8-azabiciclo [3.2.1] octano-3-metanamina enquanto ligandos dos receptores de dopamina d2 e d3 e de serotonina 5ht1a e 5ht2 - Google Patents

Derivados de 8-azabiciclo [3.2.1] octano-3-metanamina enquanto ligandos dos receptores de dopamina d2 e d3 e de serotonina 5ht1a e 5ht2

Info

Publication number
BR9812752A
BR9812752A BR9812752-7A BR9812752A BR9812752A BR 9812752 A BR9812752 A BR 9812752A BR 9812752 A BR9812752 A BR 9812752A BR 9812752 A BR9812752 A BR 9812752A
Authority
BR
Brazil
Prior art keywords
group
methanamine
dopamine
octane
receptors
Prior art date
Application number
BR9812752-7A
Other languages
English (en)
Portuguese (pt)
Inventor
Benoit Marabout
Mireille Sevrin
Pascal George
Jean-Pierre Merly
Daniele De Peretti
Jocelyne Roy
David Machnik
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9712583A external-priority patent/FR2769629B1/fr
Priority claimed from FR9712580A external-priority patent/FR2769628B1/fr
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR9812752A publication Critical patent/BR9812752A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
BR9812752-7A 1997-10-09 1998-10-07 Derivados de 8-azabiciclo [3.2.1] octano-3-metanamina enquanto ligandos dos receptores de dopamina d2 e d3 e de serotonina 5ht1a e 5ht2 BR9812752A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9712583A FR2769629B1 (fr) 1997-10-09 1997-10-09 Derives de 8-azabicyclo[3.2.1]octane-3-methanamine, leur preparation et leur application en therapeutique
FR9712580A FR2769628B1 (fr) 1997-10-09 1997-10-09 Derives de n-(2,3-dihydro-1h-inden-2-yl)-n-propyl-8- azabicyclo[3.2.1.]octane-3-methanamine, leur preparation et leur application en therapeutique
PCT/FR1998/002137 WO1999019325A1 (fr) 1997-10-09 1998-10-07 Derives de 8-azabicyclo [3.2.1] octane-3-methanamine en tant que ligands des recepteurs de dopamine d2 et d3 et de serotonine 5ht1a et 5ht2

Publications (1)

Publication Number Publication Date
BR9812752A true BR9812752A (pt) 2000-08-29

Family

ID=26233854

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812752-7A BR9812752A (pt) 1997-10-09 1998-10-07 Derivados de 8-azabiciclo [3.2.1] octano-3-metanamina enquanto ligandos dos receptores de dopamina d2 e d3 e de serotonina 5ht1a e 5ht2

Country Status (31)

Country Link
US (1) US6221879B1 (no)
EP (1) EP1021442B1 (no)
JP (1) JP4505135B2 (no)
KR (1) KR20010015717A (no)
CN (1) CN1140526C (no)
AR (1) AR017300A1 (no)
AT (1) ATE212631T1 (no)
AU (1) AU746935B2 (no)
BG (1) BG64859B1 (no)
BR (1) BR9812752A (no)
CA (1) CA2305468C (no)
CO (1) CO5011097A1 (no)
CZ (1) CZ290679B6 (no)
DE (1) DE69803689T2 (no)
DK (1) DK1021442T3 (no)
EE (1) EE04347B1 (no)
ES (1) ES2171306T3 (no)
HK (1) HK1029108A1 (no)
HU (1) HUP0102086A3 (no)
IL (2) IL135520A0 (no)
NO (1) NO325170B1 (no)
NZ (1) NZ503829A (no)
PL (1) PL186998B1 (no)
PT (1) PT1021442E (no)
RU (1) RU2203281C2 (no)
SI (1) SI1021442T1 (no)
SK (1) SK283080B6 (no)
TR (1) TR200000942T2 (no)
TW (1) TW444014B (no)
UA (1) UA58476C2 (no)
WO (1) WO1999019325A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US7834048B2 (en) * 2004-10-14 2010-11-16 Abbott Gmbh & Co. Kg Azabicycloheptyl compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
AU2006214233A1 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
JP5661791B2 (ja) 2010-03-11 2015-01-28 大日本住友製薬株式会社 Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩
CN114403335A (zh) * 2014-12-09 2022-04-29 以西结·戈兰 酒精饮料替代品
CN112500301B (zh) * 2014-12-09 2024-02-13 以西结·戈兰 放纵行为调节剂
KR102128782B1 (ko) 2018-09-20 2020-07-01 한양대학교 에리카산학협력단 트로페인(Tropane) 알칼로이드 화합물 및 순차적 산화반응을 이용한 이의 제조방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
JPS5592384A (en) * 1978-12-30 1980-07-12 Beecham Group Ltd Compound having pharmacological activity
US4350691A (en) * 1979-12-20 1982-09-21 Beecham Group Limited Certain azabicyclocarboxamides and compositions containing same
US4910302A (en) 1988-12-19 1990-03-20 American Home Products Corporation Psychotropic polycyclic imides
FR2659323B1 (fr) 1990-03-07 1992-06-12 Synthelabo Derives de 4-(aminomethyl) piperidine, leur preparation et leur application en therapeutique.
FR2681320B1 (fr) * 1991-09-12 1994-01-14 Synthelabo Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
FR2681325B1 (fr) 1991-09-16 1993-12-17 Fabre Medicament Pierre Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
FR2702211B1 (fr) 1993-03-04 1995-06-02 Pf Medicament Nouveaux dérivés de la phénoxy-2 éthylamine, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
TR200000942T2 (tr) 2000-09-21
US6221879B1 (en) 2001-04-24
CN1140526C (zh) 2004-03-03
CZ290679B6 (cs) 2002-09-11
CA2305468A1 (en) 1999-04-22
CN1281455A (zh) 2001-01-24
CZ20001278A3 (cs) 2000-07-12
EE200000207A (et) 2001-04-16
PT1021442E (pt) 2002-06-28
JP4505135B2 (ja) 2010-07-21
KR20010015717A (ko) 2001-02-26
NO325170B1 (no) 2008-02-11
BG64859B1 (bg) 2006-07-31
HUP0102086A3 (en) 2002-09-30
UA58476C2 (uk) 2003-08-15
CO5011097A1 (es) 2001-02-28
CA2305468C (en) 2007-09-25
DE69803689D1 (de) 2002-03-14
JP2001519431A (ja) 2001-10-23
DE69803689T2 (de) 2002-10-10
EP1021442A1 (fr) 2000-07-26
AR017300A1 (es) 2001-09-05
IL135520A (en) 2007-07-24
EE04347B1 (et) 2004-08-16
SK283080B6 (sk) 2003-02-04
TW444014B (en) 2001-07-01
NO20001810L (no) 2000-06-09
HK1029108A1 (en) 2001-03-23
DK1021442T3 (da) 2002-05-13
NO20001810D0 (no) 2000-04-07
PL186998B1 (pl) 2004-04-30
PL339764A1 (en) 2001-01-02
HUP0102086A2 (hu) 2001-12-28
RU2203281C2 (ru) 2003-04-27
SI1021442T1 (en) 2002-08-31
IL135520A0 (en) 2001-05-20
ES2171306T3 (es) 2002-09-01
AU746935B2 (en) 2002-05-09
AU9446898A (en) 1999-05-03
SK5042000A3 (en) 2001-03-12
WO1999019325A1 (fr) 1999-04-22
EP1021442B1 (fr) 2002-01-30
BG104309A (en) 2001-05-31
NZ503829A (en) 2002-03-28
ATE212631T1 (de) 2002-02-15

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS (FR)

Free format text: ALTERADO DE: SANOFI-SYNTHELABO

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE NAO ESTA DE ACORDO COM OS ART. 8O E 13 DA LPI.

B15K Others concerning applications: alteration of classification

Free format text: ALTERACAO DA INT.CI: C07D 451/02; A61K 31/36; A61P 25/18.

Ipc: C07D 451/02 (2008.04), A61K 31/36 (2008.04), A61P

B12B Appeal against refusal [chapter 12.2 patent gazette]